Open Access
Proceedings of the National Academy of Sciences of the United States of America, volume 116, issue 11, pages 4940-4945
LINC00116 codes for a mitochondrial peptide linking respiration and lipid metabolism
Chugunova Anastasia
1, 2
,
Loseva Elizaveta
2
,
Mazin Pavel
3, 4, 5
,
Mitina Aleksandra
3
,
Navalayeu Tsimafei
2
,
Bilan Dmitry
6, 7
,
Marey Maria
8
,
Golovina Anna
9
,
Serebryakova Marina
1, 9
,
Pletnev Philipp
1, 2
,
Rubtsova Maria
1, 2, 9
,
Mair Waltraud
3
,
Vanyushkina Anna
3
,
Belousov Vsevolod
6, 7, 10
,
Vyssokikh M. Yu.
8, 9
,
Sergiev Petr
1, 2, 9, 11
,
Dontsova Olga
1, 2, 6, 9
4
10
Institute for Cardiovascular Physiology, Georg August University Göttingen, 37073 Göttingen, Germany;
|
Publication type: Journal Article
Publication date: 2019-02-22
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 11.1
ISSN: 00278424, 10916490
PubMed ID:
30796188
Multidisciplinary
Abstract
Genes coding for small peptides have been frequently misannotated as long noncoding RNA (lncRNA) genes. Here we have demonstrated that one such transcript is translated into a 56-amino-acid-long peptide conserved in chordates, corroborating the work published while this manuscript was under review. The Mtln peptide could be detected in mitochondria of mouse cell lines and tissues. In line with its mitochondrial localization, lack of the Mtln decreases the activity of mitochondrial respiratory chain complex I. Unlike the integral components and assembly factors of NADH:ubiquinone oxidoreductase, Mtln does not alter its enzymatic activity directly. Interaction of Mtln with NADH-dependent cytochrome b5 reductase stimulates complex I functioning most likely by providing a favorable lipid composition of the membrane. Study of Mtln illuminates the importance of small peptides, whose genes might frequently be misannotated as lncRNAs, for the control of vitally important cellular processes.
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5
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25
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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GOST
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Chugunova A. et al. LINC00116 codes for a mitochondrial peptide linking respiration and lipid metabolism // Proceedings of the National Academy of Sciences of the United States of America. 2019. Vol. 116. No. 11. pp. 4940-4945.
GOST all authors (up to 50)
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Chugunova A., Loseva E., Mazin P., Mitina A., Navalayeu T., Bilan D., Vishnyakova P., Marey M., Golovina A., Serebryakova M., Pletnev P., Rubtsova M., Mair W., Vanyushkina A., Khaitovich P., Belousov V., Vyssokikh M. Y., Sergiev P., Dontsova O. LINC00116 codes for a mitochondrial peptide linking respiration and lipid metabolism // Proceedings of the National Academy of Sciences of the United States of America. 2019. Vol. 116. No. 11. pp. 4940-4945.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1073/pnas.1809105116
UR - https://doi.org/10.1073%2Fpnas.1809105116
TI - LINC00116 codes for a mitochondrial peptide linking respiration and lipid metabolism
T2 - Proceedings of the National Academy of Sciences of the United States of America
AU - Chugunova, Anastasia
AU - Loseva, Elizaveta
AU - Mazin, Pavel
AU - Mitina, Aleksandra
AU - Navalayeu, Tsimafei
AU - Bilan, Dmitry
AU - Vishnyakova, Polina
AU - Marey, Maria
AU - Golovina, Anna
AU - Serebryakova, Marina
AU - Pletnev, Philipp
AU - Rubtsova, Maria
AU - Mair, Waltraud
AU - Vanyushkina, Anna
AU - Khaitovich, Philipp
AU - Belousov, Vsevolod
AU - Vyssokikh, M. Yu.
AU - Sergiev, Petr
AU - Dontsova, Olga
PY - 2019
DA - 2019/02/22 00:00:00
PB - Proceedings of the National Academy of Sciences (PNAS)
SP - 4940-4945
IS - 11
VL - 116
PMID - 30796188
SN - 0027-8424
SN - 1091-6490
ER -
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@article{2019_Chugunova,
author = {Anastasia Chugunova and Elizaveta Loseva and Pavel Mazin and Aleksandra Mitina and Tsimafei Navalayeu and Dmitry Bilan and Polina Vishnyakova and Maria Marey and Anna Golovina and Marina Serebryakova and Philipp Pletnev and Maria Rubtsova and Waltraud Mair and Anna Vanyushkina and Philipp Khaitovich and Vsevolod Belousov and M. Yu. Vyssokikh and Petr Sergiev and Olga Dontsova},
title = {LINC00116 codes for a mitochondrial peptide linking respiration and lipid metabolism},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
year = {2019},
volume = {116},
publisher = {Proceedings of the National Academy of Sciences (PNAS)},
month = {feb},
url = {https://doi.org/10.1073%2Fpnas.1809105116},
number = {11},
pages = {4940--4945},
doi = {10.1073/pnas.1809105116}
}
Cite this
MLA
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Chugunova, Anastasia, et al. “LINC00116 codes for a mitochondrial peptide linking respiration and lipid metabolism.” Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 11, Feb. 2019, pp. 4940-4945. https://doi.org/10.1073%2Fpnas.1809105116.