Open Access
Proceedings of the National Academy of Sciences of the United States of America, volume 116, issue 41, pages 20453-20461
DDX5 helicase resolves G-quadruplex and is involved in MYC gene transcriptional activation
Publication type: Journal Article
Publication date: 2019-09-23
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 11.1
ISSN: 00278424, 10916490
Multidisciplinary
Abstract
Significance
G-quadruplexes (G4) are 4-stranded nucleic acid secondary structures. MYC is a critical oncogene with a G4 in its promoter (MycG4), which acts as a transcription silencer. MycG4 is very stable and the pathological activation of MYC in cancers requires its active unfolding. We reveal herein that DDX5, a founding member of the DEAD-box RNA helicase family, can unfold DNA G4s. The unfolding mechanism of DDX5 is distinct from previously characterized G4 helicases. Importantly, DDX5 activates MYC gene transcription by proficiently unfolding the promoter MycG4. DDX5 is overexpressed in cancers and the DDX5–MycG4 interaction can be inhibited by small molecules to downregulate MYC . Therefore, our results suggest a new molecular target to suppress MYC for cancer intervention.
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Wu G. et al. DDX5 helicase resolves G-quadruplex and is involved in MYC gene transcriptional activation // Proceedings of the National Academy of Sciences of the United States of America. 2019. Vol. 116. No. 41. pp. 20453-20461.
GOST all authors (up to 50)
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Wu G., Zheng X., Tran E., Yang D. DDX5 helicase resolves G-quadruplex and is involved in MYC gene transcriptional activation // Proceedings of the National Academy of Sciences of the United States of America. 2019. Vol. 116. No. 41. pp. 20453-20461.
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RIS
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TY - JOUR
DO - 10.1073/pnas.1909047116
UR - https://doi.org/10.1073/pnas.1909047116
TI - DDX5 helicase resolves G-quadruplex and is involved in MYC gene transcriptional activation
T2 - Proceedings of the National Academy of Sciences of the United States of America
AU - Wu, Guan-Hui
AU - Zheng, Xing
AU - Tran, Elizabeth
AU - Yang, Danzhou
PY - 2019
DA - 2019/09/23
PB - Proceedings of the National Academy of Sciences (PNAS)
SP - 20453-20461
IS - 41
VL - 116
SN - 0027-8424
SN - 1091-6490
ER -
Cite this
BibTex
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@article{2019_Wu,
author = {Guan-Hui Wu and Xing Zheng and Elizabeth Tran and Danzhou Yang},
title = {DDX5 helicase resolves G-quadruplex and is involved in MYC gene transcriptional activation},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
year = {2019},
volume = {116},
publisher = {Proceedings of the National Academy of Sciences (PNAS)},
month = {sep},
url = {https://doi.org/10.1073/pnas.1909047116},
number = {41},
pages = {20453--20461},
doi = {10.1073/pnas.1909047116}
}
Cite this
MLA
Copy
Wu, Guan-Hui, et al. “DDX5 helicase resolves G-quadruplex and is involved in MYC gene transcriptional activation.” Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 41, Sep. 2019, pp. 20453-20461. https://doi.org/10.1073/pnas.1909047116.