Reply to Wostyn et al.: Investigating the spaceflight-associated neuro-ocular syndrome and the human brain in lockstep

We thank Wostyn et al. (1) for their positive and insightful comments with respect to the association of the symptoms of the spaceflight-associated neuro-ocular syndrome (SANS) and our region-of-interest analysis of the brain’s ventricular cerebrospinal fluid (CSF) system after long-duration spaceflight (2). We would like to expand upon some points raised in the commentary. Our data show a substantial and quantifiable expansion of the ventricles. Other anatomical regions of the CSF space such as the chiasmatic and the lamina terminalis cisterns, localized much closer to the optic nerve and eye, also show a clear postflight expansion [for details, please refer to Figure 1a of our previous work (3)]. These … [↵][1]1To whom correspondence may be addressed. Email: angelique.vanombergen{at}uantwerpen.be. [1]: #xref-corresp-1-1