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Synthetic Communications
,  том 51 ,  издание 16 ,  страницы 2521-2527

Synthesis and anticancer activity of novel 2-alkylthio-4-amino-5-(thiazol-2-YL)pyrimidines

Тип публикации: Journal Article
Дата публикации: 2021-06-21
Taylor & Francis
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WOS Q3
БС2
SJR: 0.269
CiteScore: 4.3
Impact factor: 1.8
ISSN: 00397911, 15322432
Organic Chemistry
Краткое описание
Abstract A series of new fist-time synthesized of thiazolyl-substituted 4-aminopyrimidine was obtained on the basis of a two-stage process including thioamidation of 4-amino-5-cyanopyrimide followed by one-pot acylation and Hantzsch synthesis in good yield (52–77%). All synthesized compounds showed a good anticancer effect in antiproliferative assay (end point) on three tumor lines A431, A549 и HT-1080 Graphical Abstract
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Bunev A. S. et al. Synthesis and anticancer activity of novel 2-alkylthio-4-amino-5-(thiazol-2-YL)pyrimidines // Synthetic Communications. 2021. Vol. 51. No. 16. pp. 2521-2527.
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Bunev A. S., Khochenkov D. A., Khochenkov D. A., Khochenkova Y. A., Machkova Y. S., Varakina E. V., Gasanov R. E., Troshina M. A., Avdyakova O. S. Synthesis and anticancer activity of novel 2-alkylthio-4-amino-5-(thiazol-2-YL)pyrimidines // Synthetic Communications. 2021. Vol. 51. No. 16. pp. 2521-2527.
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TY - JOUR
DO - 10.1080/00397911.2021.1939383
UR - https://doi.org/10.1080/00397911.2021.1939383
TI - Synthesis and anticancer activity of novel 2-alkylthio-4-amino-5-(thiazol-2-YL)pyrimidines
T2 - Synthetic Communications
AU - Bunev, Alexander S.
AU - Khochenkov, Dmitry A
AU - Khochenkov, Dmitry A.
AU - Khochenkova, Yulia A
AU - Machkova, Yulia S
AU - Varakina, Elena V
AU - Gasanov, Rovshan E
AU - Troshina, Marina A.
AU - Avdyakova, Olga S
PY - 2021
DA - 2021/06/21
PB - Taylor & Francis
SP - 2521-2527
IS - 16
VL - 51
SN - 0039-7911
SN - 1532-2432
ER -
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@article{2021_Bunev,
author = {Alexander S. Bunev and Dmitry A Khochenkov and Dmitry A. Khochenkov and Yulia A Khochenkova and Yulia S Machkova and Elena V Varakina and Rovshan E Gasanov and Marina A. Troshina and Olga S Avdyakova},
title = {Synthesis and anticancer activity of novel 2-alkylthio-4-amino-5-(thiazol-2-YL)pyrimidines},
journal = {Synthetic Communications},
year = {2021},
volume = {51},
publisher = {Taylor & Francis},
month = {jun},
url = {https://doi.org/10.1080/00397911.2021.1939383},
number = {16},
pages = {2521--2527},
doi = {10.1080/00397911.2021.1939383}
}
MLA
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Bunev, Alexander S., et al. “Synthesis and anticancer activity of novel 2-alkylthio-4-amino-5-(thiazol-2-YL)pyrimidines.” Synthetic Communications, vol. 51, no. 16, Jun. 2021, pp. 2521-2527. https://doi.org/10.1080/00397911.2021.1939383.
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