Togliatti State University

Togliatti State University

Medical Chemistry Center

Medical Chemistry Molecular design Oncology

R-33774-0B7CB-IH87G

0000-0001-6408-8329

Head of Laboratory

Bunev, Alexander Siyasatovich

Publications

82

Citations

392

h-index

11

R-33774-0B7CB-IH87G

0000-0001-6408-8329

Authorization required.

The main activities of the laboratory:

molecular design of kinase inhibitors
molecular design of autophagy inhibitors
proteolysis-oriented chimeric molecules (PROTAC)
high-performance phenotypic screening

Research directions

Phenotypic screening

+

Publications and patents

Investigation of 3-sulfamoyl coumarins against cancer-related IX and XII isoforms of human carbonic anhydrase as well as cancer cells leads to the discovery of 2-oxo-2H-benzo[h]chromene-3-sulfonamide - A new caspase-activating proapoptotic agent.

European Journal of Medicinal Chemistry (Q1), 2021, Citations: 18

Synthesis of 1-aryl-4-tosyl-5-(trifluoromethyl)-1H-imidazoles

Journal of Fluorine Chemistry (Q3), 2014, Citations: 15

Replacing the phthalimide core in thalidomide with benzotriazole

Journal of Enzyme Inhibition and Medicinal Chemistry (Q1), 2022, Citations: 11

Novel substituted 5-methyl-4-acylaminoisoxazoles as antimitotic agents: Evaluation of selectivity to LNCaP cancer cells.

Archiv der Pharmazie (Q2), 2022, Citations: 8

Synthesis and anticancer activity of novel 2-alkylthio-4-amino-5-(thiazol-2-YL)pyrimidines

Synthetic Communications (Q3), 2021, Citations: 2

Synthesis and cytotoxic activity of novel 4-amino-5-cyano-2-sulfonylpyrimidines

Mendeleev Communications (Q3), 2020, Citations: 2

Partners

Peoples' Friendship University of Russia

Lab address

Белорусская ул., 14, Тольятти

Authorization required.