Food Additives & Contaminants, volume 20, issue 9, pages 793-796
Identification of a new analogue of sildenafil added illegally to a functional food marketed for penile erectile dysfunction
M.H. Shin
1
,
M K Hong
2
,
W S Kim
1
,
Y.-J. Lee
1
,
Y C Jeoung
1
1
Busan Regional Food and Drug Administration Busan 608-829 Korea
|
2
Korea Food and Drug Administration Department of Food Evaluation Seoul 122-704 Korea
|
Publication type: Journal Article
Publication date: 2003-09-01
Journal:
Food Additives & Contaminants
scimago Q3
SJR: 0.364
CiteScore: —
Impact factor: —
ISSN: 0265203X, 14645122
PubMed ID:
13129773
General Chemistry
Chemistry (miscellaneous)
Food Science
Health, Toxicology and Mutagenesis
Public Health, Environmental and Occupational Health
Toxicology
Abstract
A new analogue of sildenafil was discovered to have been added illegally to a functional food marketed for penile erectile dysfunction. The structure of the analogue was established by various NMR spectroscopic techniques (including DEPT, COSY, TOCSY, HMQC, HMBC). Because of the addition of a methylene group to sildenafil, the main ingredient of Viagra(R), it was given the name homosildenafil, and this has never been reported previously. An analytical method using HPLC was proposed. Homosildenafil was added as a new inspection item and other foods have since been discovered to contain it.
Found
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