Structural elucidation of a tadalafil analogue found as an adulterant of a herbal product
2
Pharmaceutical Laboratory, Centre for Analytical Science , Health Sciences Authority , 11 Outram Road, Singapore 169078
|
Publication type: Journal Article
Publication date: 2006-05-01
scimago Q2
SJR: 0.434
CiteScore: —
Impact factor: —
ISSN: 0265203X, 14645122
PubMed ID:
16644591
General Chemistry
Chemistry (miscellaneous)
Food Science
Health, Toxicology and Mutagenesis
Public Health, Environmental and Occupational Health
Toxicology
Abstract
A tadalafil analogue and hydroxyhomosildenafil were isolated from a herbal product marketed for erectile dysfunction. The structure of the tadalafil analogue was elucidated using LC-UV, high resolution MS, ESI-MS/MS, IR, and NMR. The compound was determined to be (6R,12aR)-2-amino-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6] pyrido[3,4-b]indole-1,4-dione. This compound should be included as a target compound when screening for adulterants in herbal products. This is the first published paper on a tadalafil analogue and hydroxyhomosildenafil found as adulterants of a herbal product.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
5
10
15
20
25
30
|
|
|
Journal of Pharmaceutical and Biomedical Analysis
27 publications, 42.19%
|
|
|
Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment
6 publications, 9.38%
|
|
|
Rapid Communications in Mass Spectrometry
3 publications, 4.69%
|
|
|
Chemical and Pharmaceutical Bulletin
2 publications, 3.13%
|
|
|
Journal of Chromatography A
2 publications, 3.13%
|
|
|
Orvosi Hetilap
1 publication, 1.56%
|
|
|
Molecules
1 publication, 1.56%
|
|
|
Analytical and Bioanalytical Chemistry
1 publication, 1.56%
|
|
|
Drug Safety
1 publication, 1.56%
|
|
|
Food and Chemical Toxicology
1 publication, 1.56%
|
|
|
Analytica Chimica Acta
1 publication, 1.56%
|
|
|
Chirality
1 publication, 1.56%
|
|
|
Journal of Mass Spectrometry
1 publication, 1.56%
|
|
|
Journal of Separation Science
1 publication, 1.56%
|
|
|
Drug Testing and Analysis
1 publication, 1.56%
|
|
|
Analytical Methods
1 publication, 1.56%
|
|
|
RSC Advances
1 publication, 1.56%
|
|
|
Journal of Toxicology and Environmental Health - Part A: Current Issues
1 publication, 1.56%
|
|
|
Food Additives & Contaminants
1 publication, 1.56%
|
|
|
Journal of Liquid Chromatography and Related Technologies
1 publication, 1.56%
|
|
|
Clinical Toxicology
1 publication, 1.56%
|
|
|
Food and Agricultural Immunology
1 publication, 1.56%
|
|
|
Journal of Chromatographic Science
1 publication, 1.56%
|
|
|
Journal of Sexual Medicine
1 publication, 1.56%
|
|
|
Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan
1 publication, 1.56%
|
|
|
Japanese Journal of Forensic Science and Technology
1 publication, 1.56%
|
|
|
International Journal of Pharmaceutics: X
1 publication, 1.56%
|
|
|
5
10
15
20
25
30
|
Publishers
|
5
10
15
20
25
30
35
|
|
|
Elsevier
35 publications, 54.69%
|
|
|
Taylor & Francis
11 publications, 17.19%
|
|
|
Wiley
7 publications, 10.94%
|
|
|
Pharmaceutical Society of Japan
2 publications, 3.13%
|
|
|
Springer Nature
2 publications, 3.13%
|
|
|
Royal Society of Chemistry (RSC)
2 publications, 3.13%
|
|
|
Akademiai Kiado
1 publication, 1.56%
|
|
|
MDPI
1 publication, 1.56%
|
|
|
Oxford University Press
1 publication, 1.56%
|
|
|
Japanese Society for Food Hygiene and Safety
1 publication, 1.56%
|
|
|
Japanese Association of Forensic Science and Technology
1 publication, 1.56%
|
|
|
5
10
15
20
25
30
35
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
64
Total citations:
64
Citations from 2024:
1
(1.56%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Zou P. et al. Structural elucidation of a tadalafil analogue found as an adulterant of a herbal product // Food Additives & Contaminants. 2006. Vol. 23. No. 5. pp. 446-451.
GOST all authors (up to 50)
Copy
Zou P., Hou P., Low M. Y., Koh H. Structural elucidation of a tadalafil analogue found as an adulterant of a herbal product // Food Additives & Contaminants. 2006. Vol. 23. No. 5. pp. 446-451.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1080/02652030500479690
UR - https://doi.org/10.1080/02652030500479690
TI - Structural elucidation of a tadalafil analogue found as an adulterant of a herbal product
T2 - Food Additives & Contaminants
AU - Zou, Peng
AU - Hou, Peiling
AU - Low, Min Yong
AU - Koh, Hwee-Ling
PY - 2006
DA - 2006/05/01
PB - Taylor & Francis
SP - 446-451
IS - 5
VL - 23
PMID - 16644591
SN - 0265-203X
SN - 1464-5122
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2006_Zou,
author = {Peng Zou and Peiling Hou and Min Yong Low and Hwee-Ling Koh},
title = {Structural elucidation of a tadalafil analogue found as an adulterant of a herbal product},
journal = {Food Additives & Contaminants},
year = {2006},
volume = {23},
publisher = {Taylor & Francis},
month = {may},
url = {https://doi.org/10.1080/02652030500479690},
number = {5},
pages = {446--451},
doi = {10.1080/02652030500479690}
}
Cite this
MLA
Copy
Zou, Peng, et al. “Structural elucidation of a tadalafil analogue found as an adulterant of a herbal product.” Food Additives & Contaminants, vol. 23, no. 5, May. 2006, pp. 446-451. https://doi.org/10.1080/02652030500479690.