,
volume 32
,
issue 10
,
pages 1737-1748
Application of Orbitrap-mass spectrometry to differentiate isomeric sildenafil- and thiosildenafil-like analogues used for the adulteration of dietary supplements
1
a Pharmaceutical Laboratory, Applied Sciences Group , Health Sciences Authority , Singapore , Singapore.
|
Publication type: Journal Article
Publication date: 2015-07-29
scimago Q2
wos Q3
SJR: 0.526
CiteScore: 8.2
Impact factor: 2.2
ISSN: 19440049, 19440057
PubMed ID:
26179419
General Chemistry
General Medicine
Food Science
Health, Toxicology and Mutagenesis
Public Health, Environmental and Occupational Health
Toxicology
Abstract
Two groups of isomeric phosphodiestrase-type 5 inhibitors (PDE-5), consisting of four sildenafil- and three thiosildenafil-like analogues, have been successfully differentiated using high-resolution MS/MS. The optimised MS/MS data obtained from each compound were used to build a database with the aid of mass processing software. Isomeric compounds with very close chromatographic separation like dimethylsildenafil and homosildenafil could be distinguished by their unique fingerprint fragment ions in the MS/MS database. All fragment ions were within the mass tolerance of 5 ppm. One case study using an adulterated dietary supplement is included to provide more insights into this application.
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Total citations:
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Citations from 2024:
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(11.11%)
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Kee C. L., Ge X., Low M. Y. Application of Orbitrap-mass spectrometry to differentiate isomeric sildenafil- and thiosildenafil-like analogues used for the adulteration of dietary supplements // Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment. 2015. Vol. 32. No. 10. pp. 1737-1748.
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Kee C. L., Ge X., Low M. Y. Application of Orbitrap-mass spectrometry to differentiate isomeric sildenafil- and thiosildenafil-like analogues used for the adulteration of dietary supplements // Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment. 2015. Vol. 32. No. 10. pp. 1737-1748.
Cite this
RIS
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TY - JOUR
DO - 10.1080/19440049.2015.1062923
UR - https://doi.org/10.1080/19440049.2015.1062923
TI - Application of Orbitrap-mass spectrometry to differentiate isomeric sildenafil- and thiosildenafil-like analogues used for the adulteration of dietary supplements
T2 - Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment
AU - Kee, Chee Leong
AU - Ge, Xiaowei
AU - Low, Min Yong
PY - 2015
DA - 2015/07/29
PB - Taylor & Francis
SP - 1737-1748
IS - 10
VL - 32
PMID - 26179419
SN - 1944-0049
SN - 1944-0057
ER -
Cite this
BibTex (up to 50 authors)
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@article{2015_Kee,
author = {Chee Leong Kee and Xiaowei Ge and Min Yong Low},
title = {Application of Orbitrap-mass spectrometry to differentiate isomeric sildenafil- and thiosildenafil-like analogues used for the adulteration of dietary supplements},
journal = {Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment},
year = {2015},
volume = {32},
publisher = {Taylor & Francis},
month = {jul},
url = {https://doi.org/10.1080/19440049.2015.1062923},
number = {10},
pages = {1737--1748},
doi = {10.1080/19440049.2015.1062923}
}
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Kee, Chee Leong, et al. “Application of Orbitrap-mass spectrometry to differentiate isomeric sildenafil- and thiosildenafil-like analogues used for the adulteration of dietary supplements.” Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment, vol. 32, no. 10, Jul. 2015, pp. 1737-1748. https://doi.org/10.1080/19440049.2015.1062923.