Synthetic Communications, volume 51, issue 16, pages 2521-2527
Synthesis and anticancer activity of novel 2-alkylthio-4-amino-5-(thiazol-2-YL)pyrimidines
Khochenkov Dmitry A
1, 2
,
Khochenkov Dmitry A.
1, 2
,
Khochenkova Yulia A
2
,
Machkova Yulia S
2
,
Varakina Elena V
1
,
Gasanov Rovshan E
1
,
Troshina Marina A.
1
,
Avdyakova Olga S
1
Publication type: Journal Article
Publication date: 2021-06-21
Journal:
Synthetic Communications
Quartile SCImago
Q3
Quartile WOS
Q3
Impact factor: 2.1
ISSN: 00397911, 15322432
Organic Chemistry
Abstract
Abstract A series of new fist-time synthesized of thiazolyl-substituted 4-aminopyrimidine was obtained on the basis of a two-stage process including thioamidation of 4-amino-5-cyanopyrimide followed by one-pot acylation and Hantzsch synthesis in good yield (52–77%). All synthesized compounds showed a good anticancer effect in antiproliferative assay (end point) on three tumor lines A431, A549 и HT-1080 Graphical Abstract
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Beilstein Journal of Organic Chemistry
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Beilstein Journal of Organic Chemistry
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Beilstein-Institut
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Beilstein-Institut
1 publication, 100%
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Bunev A. S. et al. Synthesis and anticancer activity of novel 2-alkylthio-4-amino-5-(thiazol-2-YL)pyrimidines // Synthetic Communications. 2021. Vol. 51. No. 16. pp. 2521-2527.
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Bunev A. S., Khochenkov D. A., Khochenkov D. A., Khochenkova Y. A., Machkova Y. S., Varakina E. V., Gasanov R. E., Troshina M. A., Avdyakova O. S. Synthesis and anticancer activity of novel 2-alkylthio-4-amino-5-(thiazol-2-YL)pyrimidines // Synthetic Communications. 2021. Vol. 51. No. 16. pp. 2521-2527.
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TY - JOUR
DO - 10.1080/00397911.2021.1939383
UR - https://doi.org/10.1080%2F00397911.2021.1939383
TI - Synthesis and anticancer activity of novel 2-alkylthio-4-amino-5-(thiazol-2-YL)pyrimidines
T2 - Synthetic Communications
AU - Bunev, Alexander S.
AU - Khochenkov, Dmitry A
AU - Khochenkova, Yulia A
AU - Machkova, Yulia S
AU - Varakina, Elena V
AU - Avdyakova, Olga S
AU - Gasanov, Rovshan E
AU - Troshina, Marina A.
AU - Khochenkov, Dmitry A.
PY - 2021
DA - 2021/06/21 00:00:00
PB - Taylor & Francis
SP - 2521-2527
IS - 16
VL - 51
SN - 0039-7911
SN - 1532-2432
ER -
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@article{2021_Bunev,
author = {Alexander S. Bunev and Dmitry A Khochenkov and Yulia A Khochenkova and Yulia S Machkova and Elena V Varakina and Olga S Avdyakova and Rovshan E Gasanov and Marina A. Troshina and Dmitry A. Khochenkov},
title = {Synthesis and anticancer activity of novel 2-alkylthio-4-amino-5-(thiazol-2-YL)pyrimidines},
journal = {Synthetic Communications},
year = {2021},
volume = {51},
publisher = {Taylor & Francis},
month = {jun},
url = {https://doi.org/10.1080%2F00397911.2021.1939383},
number = {16},
pages = {2521--2527},
doi = {10.1080/00397911.2021.1939383}
}
Cite this
MLA
Copy
Bunev, Alexander S., et al. “Synthesis and anticancer activity of novel 2-alkylthio-4-amino-5-(thiazol-2-YL)pyrimidines.” Synthetic Communications, vol. 51, no. 16, Jun. 2021, pp. 2521-2527. https://doi.org/10.1080%2F00397911.2021.1939383.
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