Synthetic Communications

, volume 51 , issue 16 , pages 2521-2527

Synthesis and anticancer activity of novel 2-alkylthio-4-amino-5-(thiazol-2-YL)pyrimidines

Alexander S. Bunev ¹

Dmitry A Khochenkov ^{1, 2}

Dmitry A. Khochenkov ^{1, 2}

Yulia A Khochenkova ²

Yulia S Machkova ²

Elena V Varakina ¹

Rovshan E Gasanov ¹

Marina A. Troshina ¹

Olga S Avdyakova ¹

Hide authors affiliations Show authors affiliations: 2 affiliations

Medicinal Chemistry Center, Togliatti State University, Togliatti, Russian Federation |

Laboratory of Biomarkers and Mechanisms of Tumor Angiogenesis, N. N. Blokhin National Medical Research Center of Oncology, Moscow, Russian Federation |

Publication type: Journal Article

Publication date: 2021-06-21

Taylor & Francis

Synthetic Communications

scimago Q3

wos Q3

SJR: 0.322

CiteScore: 4.3

Impact factor: 1.8

ISSN: 00397911, 15322432

DOI: 10.1080/00397911.2021.1939383

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Organic Chemistry

Abstract

Abstract A series of new fist-time synthesized of thiazolyl-substituted 4-aminopyrimidine was obtained on the basis of a two-stage process including thioamidation of 4-amino-5-cyanopyrimide followed by one-pot acylation and Hantzsch synthesis in good yield (52–77%). All synthesized compounds showed a good anticancer effect in antiproliferative assay (end point) on three tumor lines A431, A549 и HT-1080 Graphical Abstract

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Bunev A. S. et al. Synthesis and anticancer activity of novel 2-alkylthio-4-amino-5-(thiazol-2-YL)pyrimidines // Synthetic Communications. 2021. Vol. 51. No. 16. pp. 2521-2527.

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Bunev A. S., Khochenkov D. A., Khochenkov D. A., Khochenkova Y. A., Machkova Y. S., Varakina E. V., Gasanov R. E., Troshina M. A., Avdyakova O. S. Synthesis and anticancer activity of novel 2-alkylthio-4-amino-5-(thiazol-2-YL)pyrimidines // Synthetic Communications. 2021. Vol. 51. No. 16. pp. 2521-2527.

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RIS Copy

TY - JOUR

DO - 10.1080/00397911.2021.1939383

UR - https://doi.org/10.1080/00397911.2021.1939383

TI - Synthesis and anticancer activity of novel 2-alkylthio-4-amino-5-(thiazol-2-YL)pyrimidines

T2 - Synthetic Communications

AU - Bunev, Alexander S.

AU - Khochenkov, Dmitry A

AU - Khochenkov, Dmitry A.

AU - Khochenkova, Yulia A

AU - Machkova, Yulia S

AU - Varakina, Elena V

AU - Gasanov, Rovshan E

AU - Troshina, Marina A.

AU - Avdyakova, Olga S

PY - 2021

DA - 2021/06/21

PB - Taylor & Francis

SP - 2521-2527

IS - 16

VL - 51

SN - 0039-7911

SN - 1532-2432

ER -

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BibTex (up to 50 authors) Copy

@article{2021_Bunev,

author = {Alexander S. Bunev and Dmitry A Khochenkov and Dmitry A. Khochenkov and Yulia A Khochenkova and Yulia S Machkova and Elena V Varakina and Rovshan E Gasanov and Marina A. Troshina and Olga S Avdyakova},

title = {Synthesis and anticancer activity of novel 2-alkylthio-4-amino-5-(thiazol-2-YL)pyrimidines},

journal = {Synthetic Communications},

year = {2021},

volume = {51},

publisher = {Taylor & Francis},

month = {jun},

url = {https://doi.org/10.1080/00397911.2021.1939383},

number = {16},

pages = {2521--2527},

doi = {10.1080/00397911.2021.1939383}

}

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Bunev, Alexander S., et al. “Synthesis and anticancer activity of novel 2-alkylthio-4-amino-5-(thiazol-2-YL)pyrimidines.” Synthetic Communications, vol. 51, no. 16, Jun. 2021, pp. 2521-2527. https://doi.org/10.1080/00397911.2021.1939383.