Quenching of fluorescence by meclizine, a probe study for structural and conformational changes in human serum albumin
Publication type: Journal Article
Publication date: 2016-11-10
scimago Q2
wos Q3
SJR: 0.552
CiteScore: 8.3
Impact factor: 2.4
ISSN: 07391102, 15380254
PubMed ID:
27767393
Molecular Biology
General Medicine
Structural Biology
Abstract
The goal of this study was to investigate the interactions between meclizine (MEC) and human serum albumin (HSA) under physiological conditions by different spectroscopies and molecular modeling technique. The drug, MEC quenched the intrinsic fluorescence of HSA and the analysis of the results revealed that static quenching mechanism. The binding of MEC quenches the HSA fluorescence; stoichiometry was 1:1 interaction. Thermodynamic quantities were calculated at different temperatures suggested that hydrophobic and van der Waals interaction with HSA-MEC. The molecular distance, r, between donor and acceptor was estimated according to Forster's theory of non-radiation energy transfer. CD and FT-IR studies confirm changes of secondary structure of HSA. Molecular docking studies validate MEC molecule interact to HSA in sub domain IIA.
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21
Total citations:
21
Citations from 2025:
8
(38.1%)
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GOST
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Ariga G. G. et al. Quenching of fluorescence by meclizine, a probe study for structural and conformational changes in human serum albumin // Journal of Biomolecular Structure and Dynamics. 2016. Vol. 35. No. 14. pp. 3161-3175.
GOST all authors (up to 50)
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Ariga G. G., Naik P. N., Nandibewoor S. T., Chimatadar S. A. Quenching of fluorescence by meclizine, a probe study for structural and conformational changes in human serum albumin // Journal of Biomolecular Structure and Dynamics. 2016. Vol. 35. No. 14. pp. 3161-3175.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1080/07391102.2016.1245159
UR - https://doi.org/10.1080/07391102.2016.1245159
TI - Quenching of fluorescence by meclizine, a probe study for structural and conformational changes in human serum albumin
T2 - Journal of Biomolecular Structure and Dynamics
AU - Ariga, Girish G
AU - Naik, Praveen N.
AU - Nandibewoor, Sharanappa T.
AU - Chimatadar, Shivamurti A.
PY - 2016
DA - 2016/11/10
PB - Taylor & Francis
SP - 3161-3175
IS - 14
VL - 35
PMID - 27767393
SN - 0739-1102
SN - 1538-0254
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2016_Ariga,
author = {Girish G Ariga and Praveen N. Naik and Sharanappa T. Nandibewoor and Shivamurti A. Chimatadar},
title = {Quenching of fluorescence by meclizine, a probe study for structural and conformational changes in human serum albumin},
journal = {Journal of Biomolecular Structure and Dynamics},
year = {2016},
volume = {35},
publisher = {Taylor & Francis},
month = {nov},
url = {https://doi.org/10.1080/07391102.2016.1245159},
number = {14},
pages = {3161--3175},
doi = {10.1080/07391102.2016.1245159}
}
Cite this
MLA
Copy
Ariga, Girish G., et al. “Quenching of fluorescence by meclizine, a probe study for structural and conformational changes in human serum albumin.” Journal of Biomolecular Structure and Dynamics, vol. 35, no. 14, Nov. 2016, pp. 3161-3175. https://doi.org/10.1080/07391102.2016.1245159.