New composites of betulin esters with arabinogalactan as highly potent anti-cancer agents
Тип публикации: Journal Article
Дата публикации: 2015-07-13
scimago Q2
wos Q3
БС1
SJR: 0.398
CiteScore: 5.2
Impact factor: 1.6
ISSN: 14786419, 14786427
PubMed ID:
26165861
Organic Chemistry
Biochemistry
Plant Science
Analytical Chemistry
Краткое описание
Abstract Betulin and its esters are the natural compounds with high in vitro cytotoxicity toward many cancer cells. However, the poor water solubility of these compounds has limited their applications. We prepared new composites of betulin esters using two methods, namely ball-milling of the mixtures of betulin esters with arabinogalactan and preparation of thin films of these mixtures by evaporating the aqueous solutions. These composites revealed higher water solubility as compared with the initial substances without losing the structural integrity and functionality. As a result, the new composites have shown much higher inhibitory effects against different cancer cell lines such as Ehrlich ascites carcinoma cells and lung carcinoma cells (A549) in comparison with the initial substances. The cell viability studies based on Annexin V and Propidium iodide probes have confirmed the high proapoptotic effect of betulin ester derivatives against cancer cells. Graphical abstract
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Shakhtshneider T. et al. New composites of betulin esters with arabinogalactan as highly potent anti-cancer agents // Natural Product Research. 2015. Vol. 30. No. 12. pp. 1382-1387.
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Shakhtshneider T., Kuznetsova S. A., Zamay A. S., Zamay T. N., Spivak E. A., Mikhailenko M., Malyar Yu. N., Kuznetsov B., Chesnokov N. V., Boldyrev V. V. New composites of betulin esters with arabinogalactan as highly potent anti-cancer agents // Natural Product Research. 2015. Vol. 30. No. 12. pp. 1382-1387.
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TY - JOUR
DO - 10.1080/14786419.2015.1060591
UR - https://doi.org/10.1080/14786419.2015.1060591
TI - New composites of betulin esters with arabinogalactan as highly potent anti-cancer agents
T2 - Natural Product Research
AU - Shakhtshneider, Tatyana
AU - Kuznetsova, Svetlana A.
AU - Zamay, A S
AU - Zamay, Tatiana N.
AU - Spivak, E A
AU - Mikhailenko, M.A.
AU - Malyar, Yu N
AU - Kuznetsov, B.
AU - Chesnokov, N V
AU - Boldyrev, V. V.
PY - 2015
DA - 2015/07/13
PB - Taylor & Francis
SP - 1382-1387
IS - 12
VL - 30
PMID - 26165861
SN - 1478-6419
SN - 1478-6427
ER -
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@article{2015_Shakhtshneider,
author = {Tatyana Shakhtshneider and Svetlana A. Kuznetsova and A S Zamay and Tatiana N. Zamay and E A Spivak and M.A. Mikhailenko and Yu N Malyar and B. Kuznetsov and N V Chesnokov and V. V. Boldyrev},
title = {New composites of betulin esters with arabinogalactan as highly potent anti-cancer agents},
journal = {Natural Product Research},
year = {2015},
volume = {30},
publisher = {Taylor & Francis},
month = {jul},
url = {https://doi.org/10.1080/14786419.2015.1060591},
number = {12},
pages = {1382--1387},
doi = {10.1080/14786419.2015.1060591}
}
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MLA
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Shakhtshneider, Tatyana, et al. “New composites of betulin esters with arabinogalactan as highly potent anti-cancer agents.” Natural Product Research, vol. 30, no. 12, Jul. 2015, pp. 1382-1387. https://doi.org/10.1080/14786419.2015.1060591.
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