Open Access
Open access
Taylor & Francis
RNA Biology
,  volume 12 ,  issue 9 ,  pages 966-971

A bacterial homolog YciH of eukaryotic translation initiation factor eIF1 regulates stress-related gene expression and is unlikely to be involved in translation initiation fidelity

Ilya A. Osterman 1, 2, 3
, 
Sergey A Evfratov 4
, 
Margarita M Dzama 4
, 
Philipp I Pletnev 4
, 
Sergey I. Kovalchuk 3, 5
, 
Ivan O. Butenko 6, 7
, 
Olga V. Pobeguts 6, 7
, 
Anna Ya Golovina 4
, 
Vadim M. Govorun 6, 7
, 
Alexey A. Bogdanov 4
, 
Petr V. Sergiev 4
, 
Olga A. Dontsova 4
1
 
2
 
3
 
Moscow , Russia. | 
4
 
5
 
6
 
7
 
Publication type: Journal Article
Publication date: 2015-07-15
Taylor & Francis
scimago Q1
wos Q2
SJR: 1.651
CiteScore: 8.6
Impact factor: 3.4
ISSN: 15476286, 15558584
Molecular Biology
Cell Biology
Abstract
YciH is a bacterial protein, homologous to eukaryotic translation initiation factor eIF1. Preceding evidence obtained with the aid of in vitro translation initiation system suggested that it may play a role of a translation initiation factor, ensuring selection against suboptimal initiation complexes. Here we studied the effect of Escherichia coli yciH gene inactivation on translation of model mRNAs. Neither the translation efficiency of leaderless mRNAs, nor mRNAs with non AUG start codons, was found to be affected by YciH in vivo. Comparative proteome analysis revealed that yciH gene knockout leads to a more than fold2- increase in expression of 66 genes and a more than fold2- decrease in the expression of 20 genes. Analysis of these gene sets allowed us to suggest a role of YciH as an inhibitor of translation in a stress response rather than the role of a translation initiation factor.
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Osterman I. A. et al. A bacterial homolog YciH of eukaryotic translation initiation factor eIF1 regulates stress-related gene expression and is unlikely to be involved in translation initiation fidelity // RNA Biology. 2015. Vol. 12. No. 9. pp. 966-971.
GOST all authors (up to 50) Copy
Osterman I. A., Evfratov S. A., Dzama M. M., Pletnev P. I., Kovalchuk S. I., Butenko I. O., Pobeguts O. V., Golovina A. Ya., Govorun V. M., Bogdanov A. A., Sergiev P. V., Dontsova O. A. A bacterial homolog YciH of eukaryotic translation initiation factor eIF1 regulates stress-related gene expression and is unlikely to be involved in translation initiation fidelity // RNA Biology. 2015. Vol. 12. No. 9. pp. 966-971.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1080/15476286.2015.1069464
UR - http://www.tandfonline.com/doi/full/10.1080/15476286.2015.1069464
TI - A bacterial homolog YciH of eukaryotic translation initiation factor eIF1 regulates stress-related gene expression and is unlikely to be involved in translation initiation fidelity
T2 - RNA Biology
AU - Osterman, Ilya A.
AU - Evfratov, Sergey A
AU - Dzama, Margarita M
AU - Pletnev, Philipp I
AU - Kovalchuk, Sergey I.
AU - Butenko, Ivan O.
AU - Pobeguts, Olga V.
AU - Golovina, Anna Ya
AU - Govorun, Vadim M.
AU - Bogdanov, Alexey A.
AU - Sergiev, Petr V.
AU - Dontsova, Olga A.
PY - 2015
DA - 2015/07/15
PB - Taylor & Francis
SP - 966-971
IS - 9
VL - 12
PMID - 26177339
SN - 1547-6286
SN - 1555-8584
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2015_Osterman,
author = {Ilya A. Osterman and Sergey A Evfratov and Margarita M Dzama and Philipp I Pletnev and Sergey I. Kovalchuk and Ivan O. Butenko and Olga V. Pobeguts and Anna Ya Golovina and Vadim M. Govorun and Alexey A. Bogdanov and Petr V. Sergiev and Olga A. Dontsova},
title = {A bacterial homolog YciH of eukaryotic translation initiation factor eIF1 regulates stress-related gene expression and is unlikely to be involved in translation initiation fidelity},
journal = {RNA Biology},
year = {2015},
volume = {12},
publisher = {Taylor & Francis},
month = {jul},
url = {http://www.tandfonline.com/doi/full/10.1080/15476286.2015.1069464},
number = {9},
pages = {966--971},
doi = {10.1080/15476286.2015.1069464}
}
MLA
Cite this
MLA Copy
Osterman, Ilya A., et al. “A bacterial homolog YciH of eukaryotic translation initiation factor eIF1 regulates stress-related gene expression and is unlikely to be involved in translation initiation fidelity.” RNA Biology, vol. 12, no. 9, Jul. 2015, pp. 966-971. http://www.tandfonline.com/doi/full/10.1080/15476286.2015.1069464.