Open Access
RNA Biology, volume 17, issue 4, pages 441-450
Mouse Trmt2B protein is a dual specific mitochondrial metyltransferase responsible for m5U formation in both tRNA and rRNA
Laptev Ivan G.
1, 2
,
Shvetsova Ekaterina
3
,
Levitskii Sergey
4
,
Serebryakova M. V.
2, 5
,
Serebryakova Marina
2, 5
,
Rubtsova Maria
1, 2
,
Bogdanov Alexey
1, 5
,
Bogdanov Alexey A.
1, 5
,
Kamenski Piotr
4
,
Sergiev Petr
1, 2, 5, 6
,
Dontsova Olga
1, 2, 5, 7
5
Publication type: Journal Article
Publication date: 2019-11-27
Journal:
RNA Biology
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor: 4.1
ISSN: 15476286, 15558584
PubMed ID:
31736397
Molecular Biology
Cell Biology
Abstract
ABSTRACT RNA molecules of all species contain modified nucleotides and particularly m5U residues. The vertebrate mitochondrial small subunit rRNA contains m5U nucleotide in a unique site. In this work we found an enzyme, TRMT2B, responsible for the formation of this nucleotide and m5U residues in a number of mitochondrial tRNA species. Inactivation of the Trmt2B gene leads to a reduction of the activity of respiratory chain complexes I, III and IV, containing the subunits synthesized by the mitochondrial protein synthesis apparatus. Comparative sequence analysis of m5U-specific RNA methyltransferases revealed an unusual evolutionary pathway of TRMT2B formation which includes consecutive substrate specificity switches from the large subunit rRNA to tRNA and then to the small subunit rRNA.
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1
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Laptev I. G. et al. Mouse Trmt2B protein is a dual specific mitochondrial metyltransferase responsible for m5U formation in both tRNA and rRNA // RNA Biology. 2019. Vol. 17. No. 4. pp. 441-450.
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Laptev I. G., Shvetsova E., Levitskii S., Serebryakova M., Serebryakova M. V., Rubtsova M., Bogdanov A., Bogdanov A. A., Kamenski P., Sergiev P., Dontsova O. Mouse Trmt2B protein is a dual specific mitochondrial metyltransferase responsible for m5U formation in both tRNA and rRNA // RNA Biology. 2019. Vol. 17. No. 4. pp. 441-450.
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TY - JOUR
DO - 10.1080/15476286.2019.1694733
UR - https://doi.org/10.1080%2F15476286.2019.1694733
TI - Mouse Trmt2B protein is a dual specific mitochondrial metyltransferase responsible for m5U formation in both tRNA and rRNA
T2 - RNA Biology
AU - Laptev, Ivan G.
AU - Shvetsova, Ekaterina
AU - Levitskii, Sergey
AU - Serebryakova, Marina
AU - Rubtsova, Maria
AU - Kamenski, Piotr
AU - Sergiev, Petr
AU - Dontsova, Olga
AU - Bogdanov, Alexey
AU - Serebryakova, M. V.
AU - Bogdanov, Alexey A.
PY - 2019
DA - 2019/11/27 00:00:00
PB - Taylor & Francis
SP - 441-450
IS - 4
VL - 17
PMID - 31736397
SN - 1547-6286
SN - 1555-8584
ER -
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@article{2019_Laptev,
author = {Ivan G. Laptev and Ekaterina Shvetsova and Sergey Levitskii and Marina Serebryakova and Maria Rubtsova and Piotr Kamenski and Petr Sergiev and Olga Dontsova and Alexey Bogdanov and M. V. Serebryakova and Alexey A. Bogdanov},
title = {Mouse Trmt2B protein is a dual specific mitochondrial metyltransferase responsible for m5U formation in both tRNA and rRNA},
journal = {RNA Biology},
year = {2019},
volume = {17},
publisher = {Taylor & Francis},
month = {nov},
url = {https://doi.org/10.1080%2F15476286.2019.1694733},
number = {4},
pages = {441--450},
doi = {10.1080/15476286.2019.1694733}
}
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MLA
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Laptev, Ivan G., et al. “Mouse Trmt2B protein is a dual specific mitochondrial metyltransferase responsible for m5U formation in both tRNA and rRNA.” RNA Biology, vol. 17, no. 4, Nov. 2019, pp. 441-450. https://doi.org/10.1080%2F15476286.2019.1694733.