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Open access
Emerging Microbes and Infections, volume 10, issue 1, pages 2264-2275

Host-cell interactions in HBV infection and pathogenesis: the emerging role of m6A modification

Brezgin Sergey 1, 2
Glebe Dieter 3
Chulanov Vladimir 1, 2, 4
1
 
National Medical Research Center of Tuberculosis and Infectious Diseases, Ministry of Health, Moscow, Russia
3
 
National Reference Center for Hepatitis B Viruses and Hepatitis D Viruses, Institute of Medical Virology, Justus Liebig University of Giessen, Giessen, Germany
Publication typeJournal Article
Publication date2021-01-01
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor13.2
ISSN22221751
Drug Discovery
General Medicine
Microbiology
Infectious Diseases
Immunology
Epidemiology
Parasitology
Virology
Abstract
Hepatitis B virus (HBV) is a DNA virus with a complex life cycle that includes a reverse transcription step. HBV is poorly sensed by the immune system and frequently establishes persistent infection that can cause chronic infection, the leading cause of liver cancer and cirrhosis worldwide. Recent mounting evidence has indicated the growing importance of RNA methylation (m6A modification) in viral replication, immune escape, and carcinogenesis. The value of m6A RNA modification for the prediction and clinical management of chronic HBV infection remains to be assessed. However, a number of studies indicate the important role of m6A-marked transcripts and factors of m6A machinery in managing HBV-related pathologies. In this review, we discuss the fundamental and potential clinical impact of m6A modifications on HBV infection and pathogenesis, as well as highlight the important molecular techniques and tools that can be used for studying RNA m6A methylome.

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Kostyusheva A. et al. Host-cell interactions in HBV infection and pathogenesis: the emerging role of m6A modification // Emerging Microbes and Infections. 2021. Vol. 10. No. 1. pp. 2264-2275.
GOST all authors (up to 50) Copy
Kostyusheva A., Brezgin S., Glebe D., Kostyushev D., Chulanov V. Host-cell interactions in HBV infection and pathogenesis: the emerging role of m6A modification // Emerging Microbes and Infections. 2021. Vol. 10. No. 1. pp. 2264-2275.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1080/22221751.2021.2006580
UR - https://doi.org/10.1080%2F22221751.2021.2006580
TI - Host-cell interactions in HBV infection and pathogenesis: the emerging role of m6A modification
T2 - Emerging Microbes and Infections
AU - Kostyusheva, Anastasiya
AU - Brezgin, Sergey
AU - Glebe, Dieter
AU - Kostyushev, Dmitry
AU - Chulanov, Vladimir
PY - 2021
DA - 2021/01/01 00:00:00
PB - Springer Nature
SP - 2264-2275
IS - 1
VL - 10
PMID - 34767497
SN - 2222-1751
ER -
BibTex |
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BibTex Copy
@article{2021_Kostyusheva
author = {Anastasiya Kostyusheva and Sergey Brezgin and Dieter Glebe and Dmitry Kostyushev and Vladimir Chulanov},
title = {Host-cell interactions in HBV infection and pathogenesis: the emerging role of m6A modification},
journal = {Emerging Microbes and Infections},
year = {2021},
volume = {10},
publisher = {Springer Nature},
month = {jan},
url = {https://doi.org/10.1080%2F22221751.2021.2006580},
number = {1},
pages = {2264--2275},
doi = {10.1080/22221751.2021.2006580}
}
MLA
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MLA Copy
Kostyusheva, Anastasiya, et al. “Host-cell interactions in HBV infection and pathogenesis: the emerging role of m6A modification.” Emerging Microbes and Infections, vol. 10, no. 1, Jan. 2021, pp. 2264-2275. https://doi.org/10.1080%2F22221751.2021.2006580.
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