Sechenov First Moscow State Medical University

Laboratory of Genetic Technologies

Biomedicine Virology Molecular Biology

Head of Laboratory

Kostyushev, Dmitry S

PhD in Biological/biomedical sciences

Publications

Citations

722

h-index

Authorization required.

Genetic editing, viral hepatitis, drug delivery, intracellular immunity, epitranscriptomics

Cell and tissue culture
PCR
Real-time PCR (qPCR)
Flow cytometry
Column chromatography
Enzyme-linked immunosorbent assay (ELISA)
Transfection
Transformation
Work with eukaryotic cells: cultivation, transfection, infection
Working with prokaryotic cells: cultivation, transformation, working with phages
Various methods for the production of biomaterials/biocomposites, supramolecular complexes and sols of nanoparticles.

Dmitry Kostyushev 🥼 🤝

Head of Laboratory

Anastasiya Kostyusheva 🥼 🤝

Senior Researcher

Sergey Brezgin 🤝

Senior Researcher

Research directions

Delivery of in vivo genetic editing systems

Packaging and targeted delivery of genetic editing systems using biological nanoparticles

Publications and patents

Orthologous CRISPR/Cas9 systems for specific and efficient degradation of covalently closed circular DNA of hepatitis B virus

Cellular and Molecular Life Sciences (Q1), 2019, Citations: 59

Suppressing the NHEJ pathway by DNA-PKcs inhibitor NU7026 prevents degradation of HBV cccDNA cleaved by CRISPR/Cas9

Scientific Reports (Q1), 2019, Citations: 39

ATM and ATR Expression Potentiates HBV Replication and Contributes to Reactivation of HBV Infection upon DNA Damage

Viruses (Q1), 2019, Citations: 22

Replenishment of Hepatitis B Virus cccDNA Pool Is Restricted by Baseline Expression of Host Restriction Factors In Vitro

Microorganisms (Q2), 2019, Citations: 11

Overexpression of Nitric Oxide Synthase Restores Circulating Angiogenic Cell Function in Patients With Coronary Artery Disease: Implications for Autologous Cell Therapy for Myocardial Infarction

Journal of the American Heart Association (Q1), 2016, Citations: 10

Age-Related Impaired Efficacy of Bone Marrow Cell Therapy for Myocardial Infarction Reflects a Decrease in B Lymphocytes.

Molecular Therapy (Q1), 2018, Citations: 6

By date By citations

Partners

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences

Lab address

ул. Трубецкая, д.8, стр.2

Authorization required.