Journal Physics D: Applied Physics, volume 55, issue 4, pages 45402
Sonodynamic effect in A375 melanoma cells with chlorin e6 induced by 20 kHz ultrasound
Publication type: Journal Article
Publication date: 2021-10-26
Journal:
Journal Physics D: Applied Physics
Quartile SCImago
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Quartile WOS
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Impact factor: 3.4
ISSN: 00223727, 13616463
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Acoustics and Ultrasonics
Abstract
In this research, combined effect of chlorin e6 and noninvasive 20 kHz, low-powered ultrasound on melanoma cells is proposed for the first time. The proposed combination incorporates the application of safe low-frequency ultrasound that is used for transdermal drug delivery. We demonstrate that impact of the 20 kHz ultrasound on chlorin e6 leads to strong sonodynamic effect in melanoma cells. We also show that chlorin e6 keeps its monomeric form in the cells and does not aggregate after exposure to ultrasound. We propose a two-step model where sonoluminescence serves as an internal light source for the chlorin e6 photoactivation.
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Dadadzhanova A. et al. Sonodynamic effect in A375 melanoma cells with chlorin e6 induced by 20 kHz ultrasound // Journal Physics D: Applied Physics. 2021. Vol. 55. No. 4. p. 45402.
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Dadadzhanova A., Kolesova E. P., Maslov V., Amar Lewis E., Goldbart R., Traitel T., Kost J., Orlova A. Sonodynamic effect in A375 melanoma cells with chlorin e6 induced by 20 kHz ultrasound // Journal Physics D: Applied Physics. 2021. Vol. 55. No. 4. p. 45402.
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TY - JOUR
DO - 10.1088/1361-6463/ac2f16
UR - https://doi.org/10.1088%2F1361-6463%2Fac2f16
TI - Sonodynamic effect in A375 melanoma cells with chlorin e6 induced by 20 kHz ultrasound
T2 - Journal Physics D: Applied Physics
AU - Dadadzhanova, Antonina
AU - Kolesova, Ekaterina P
AU - Maslov, Vladimir
AU - Amar Lewis, Eliz
AU - Goldbart, Riki
AU - Traitel, Tamar
AU - Kost, Joseph
AU - Orlova, A.
PY - 2021
DA - 2021/10/26 00:00:00
PB - IOP Publishing
SP - 45402
IS - 4
VL - 55
SN - 0022-3727
SN - 1361-6463
ER -
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@article{2021_Dadadzhanova,
author = {Antonina Dadadzhanova and Ekaterina P Kolesova and Vladimir Maslov and Eliz Amar Lewis and Riki Goldbart and Tamar Traitel and Joseph Kost and A. Orlova},
title = {Sonodynamic effect in A375 melanoma cells with chlorin e6 induced by 20 kHz ultrasound},
journal = {Journal Physics D: Applied Physics},
year = {2021},
volume = {55},
publisher = {IOP Publishing},
month = {oct},
url = {https://doi.org/10.1088%2F1361-6463%2Fac2f16},
number = {4},
pages = {45402},
doi = {10.1088/1361-6463/ac2f16}
}
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Dadadzhanova, Antonina, et al. “Sonodynamic effect in A375 melanoma cells with chlorin e6 induced by 20 kHz ultrasound.” Journal Physics D: Applied Physics, vol. 55, no. 4, Oct. 2021, p. 45402. https://doi.org/10.1088%2F1361-6463%2Fac2f16.