Nanotechnology

, volume 26 , issue 5 , pages 55101

Comparative toxicity evaluation of flower-shaped and spherical gold nanoparticles on human endothelial cells

Sadequa Sultana ¹

Nadia Djaker ¹

Sanda Boca Farcau ²

Milena Salerno ¹

Nathalie Charnaux ³

S. Astilean ²

Hanna Hlawaty ³

Cristiano D’Andrea ¹

Hide authors affiliations Show authors affiliations: 3 affiliations

Université Paris 13, Sorbonne Paris Cité, UFR SMBH, Laboratoire CSPBAT, CNRS (UMR 7244), 74 rue Marcel Cachin, F-93017 Bobigny, France.

Paris Cité University

Sorbonne Paris Nord University

Babes-Bolyai University, Institute for Interdisciplinary Research in Bio-Nanosciences and Faculty of Physics, Nanobiophotonics and Laser Microspectroscopy Center, 1 Str. M Kogalniceanu, RO-400084 Cluj-Napoca, Romania |

Université Paris 13, Sorbonne Paris Cité, UFR SMBH, INSERM U1148, Laboratory for Vascular Translational Science, Bio-ingénierie cardio-vasculaire, 74 rue Marcel Cachin, F-93017 Bobigny, France

Paris Cité University

Sorbonne Paris Nord University

French Institute of Health and Medical Research

Publication type: Journal Article

Publication date: 2015-01-09

IOP Publishing

Nanotechnology

scimago Q2

wos Q2

SJR: 0.597

CiteScore: 6.2

Impact factor: 2.8

ISSN: 09574484, 13616528

DOI: 10.1088/0957-4484/26/5/055101

Copy DOI

PubMed ID: 25573907

General Chemistry

General Materials Science

Electrical and Electronic Engineering

Mechanical Engineering

Bioengineering

Mechanics of Materials

Abstract

In this paper, we propose a multi-parametric in vitro study of the cytotoxicity of gold nanoparticles (GNPs) on human endothelial cell (HUVEC). The cytotoxicity is evaluated by incubating cells with six different GNP types which have two different morphologies: spherical and flower-shaped, two sizes (∼15 and ∼50 nm diameter) and two surface chemistries (as prepared form and PEGylated form). Our results showed that by increasing the concentration of GNPs the cell viability decreases with a toxic concentration threshold of 10 pM for spherical GNPs and of 1 pM for flower-shaped GNPs. Dark field images, flow cytometry and spreading test revealed that flower-shaped GNPs have more deleterious effects on the cell mechanisms than spherical GNPs. We demonstrated that the main parameter in the evaluation of the GNPs toxicity is the GNPs roughness and that this effect is independent on the surface chemistry. We assume that this behavior is highly related to the efficiency of the GNPs internalization within the cells and that this effect is enhanced due to the specific geometry of the flower-shaped GNPs.

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Falchevskaya Aleksandra

PhD in Chemistry, lecturer

12 publications, 206 citations

h-index: 7

ITMO University

1 citation

Kladko Daniil

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PhD in Chemistry

12 publications, 254 citations

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Sultana S. et al. Comparative toxicity evaluation of flower-shaped and spherical gold nanoparticles on human endothelial cells // Nanotechnology. 2015. Vol. 26. No. 5. p. 55101.

GOST all authors (up to 50) Copy

Sultana S., Djaker N., Boca Farcau S., Salerno M., Charnaux N., Astilean S., Hlawaty H., D’Andrea C. Comparative toxicity evaluation of flower-shaped and spherical gold nanoparticles on human endothelial cells // Nanotechnology. 2015. Vol. 26. No. 5. p. 55101.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1088/0957-4484/26/5/055101

UR - https://doi.org/10.1088/0957-4484/26/5/055101

TI - Comparative toxicity evaluation of flower-shaped and spherical gold nanoparticles on human endothelial cells

T2 - Nanotechnology

AU - Sultana, Sadequa

AU - Djaker, Nadia

AU - Boca Farcau, Sanda

AU - Salerno, Milena

AU - Charnaux, Nathalie

AU - Astilean, S.

AU - Hlawaty, Hanna

AU - D’Andrea, Cristiano

PY - 2015

DA - 2015/01/09

PB - IOP Publishing

SP - 55101

IS - 5

VL - 26

PMID - 25573907

SN - 0957-4484

SN - 1361-6528

ER -

BibTex |

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BibTex (up to 50 authors) Copy

@article{2015_Sultana,

author = {Sadequa Sultana and Nadia Djaker and Sanda Boca Farcau and Milena Salerno and Nathalie Charnaux and S. Astilean and Hanna Hlawaty and Cristiano D’Andrea},

title = {Comparative toxicity evaluation of flower-shaped and spherical gold nanoparticles on human endothelial cells},

journal = {Nanotechnology},

year = {2015},

volume = {26},

publisher = {IOP Publishing},

month = {jan},

url = {https://doi.org/10.1088/0957-4484/26/5/055101},

number = {5},

pages = {55101},

doi = {10.1088/0957-4484/26/5/055101}

}

MLA

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MLA Copy

Sultana, Sadequa, et al. “Comparative toxicity evaluation of flower-shaped and spherical gold nanoparticles on human endothelial cells.” Nanotechnology, vol. 26, no. 5, Jan. 2015, p. 55101. https://doi.org/10.1088/0957-4484/26/5/055101.

Publisher

IOP Publishing

Journal

Nanotechnology

scimago Q2

wos Q2

SJR

0.597

CiteScore

6.2

Impact factor

2.8

ISSN

09574484 (Print)

13616528 (Electronic)