Angiogenic potential of spheroids from umbilical cord and adipose-derived multipotent mesenchymal stromal cells within fibrin gel
Irina M Zurina
3
,
Anastasia Koroleva
4
,
Denis A Nikishin
5, 6
,
Denis Butnaru
2
,
Petr S. Timashev
7, 8
,
V S Repin
3
,
1
4
Laser Zentrum Hannover E.V., Hannover, Germany
|
7
Publication type: Journal Article
Publication date: 2018-05-22
scimago Q2
wos Q2
SJR: 0.716
CiteScore: 6.8
Impact factor: 3.7
ISSN: 17486041, 1748605X
PubMed ID:
29722292
Bioengineering
Biomaterials
Biomedical Engineering
Abstract
One of the essential goals in regenerative medicine is microvascularization which enables an effective blood supply within de novo constructed tissues and organs. In our study, we used two common multipotent mesenchymal stromal cell (MMSC) sources (subcutaneous adipose tissue and Wharton's jelly of the umbilical cord) where is a subpopulation of endothelial precursors. In the medium supplemented with VEGF, the 3D cultures of UC MMSCs and ADSCs promoted the endothelial cell differentiation. To evaluate their ability to form a capillary-like network, we encapsulated spheroids within non-modified and PEGylated fibrin hydrogels. The PEGylated hydrogel supported better the formation of multibranched cords than the pure fibrin gel. Analysis of tubule growth rate, length, and branching showed that the differentiated ADSCs had higher angiogenic potential than the differentiated hUC MMSCs. Our study can be a basis for the development of new strategies in tissue engineering and treatment of vascular diseases.
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Total citations:
27
Citations from 2024:
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(7%)
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MLA
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GOST
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Gorkun A. et al. Angiogenic potential of spheroids from umbilical cord and adipose-derived multipotent mesenchymal stromal cells within fibrin gel // Biomedical Materials (Bristol). 2018. Vol. 13. No. 4. p. 44108.
GOST all authors (up to 50)
Copy
Gorkun A., Shpichka A. I., Zurina I. M., Koroleva A., Kosheleva N. V., Nikishin D. A., Butnaru D., Timashev P. S., Repin V. S., Saburina I. N. Angiogenic potential of spheroids from umbilical cord and adipose-derived multipotent mesenchymal stromal cells within fibrin gel // Biomedical Materials (Bristol). 2018. Vol. 13. No. 4. p. 44108.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1088/1748-605X/aac22d
UR - https://iopscience.iop.org/article/10.1088/1748-605X/aac22d
TI - Angiogenic potential of spheroids from umbilical cord and adipose-derived multipotent mesenchymal stromal cells within fibrin gel
T2 - Biomedical Materials (Bristol)
AU - Gorkun, Anastasiya
AU - Shpichka, Anastasia I.
AU - Zurina, Irina M
AU - Koroleva, Anastasia
AU - Kosheleva, Nastasia V.
AU - Nikishin, Denis A
AU - Butnaru, Denis
AU - Timashev, Petr S.
AU - Repin, V S
AU - Saburina, I N
PY - 2018
DA - 2018/05/22
PB - IOP Publishing
SP - 44108
IS - 4
VL - 13
PMID - 29722292
SN - 1748-6041
SN - 1748-605X
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2018_Gorkun,
author = {Anastasiya Gorkun and Anastasia I. Shpichka and Irina M Zurina and Anastasia Koroleva and Nastasia V. Kosheleva and Denis A Nikishin and Denis Butnaru and Petr S. Timashev and V S Repin and I N Saburina},
title = {Angiogenic potential of spheroids from umbilical cord and adipose-derived multipotent mesenchymal stromal cells within fibrin gel},
journal = {Biomedical Materials (Bristol)},
year = {2018},
volume = {13},
publisher = {IOP Publishing},
month = {may},
url = {https://iopscience.iop.org/article/10.1088/1748-605X/aac22d},
number = {4},
pages = {44108},
doi = {10.1088/1748-605X/aac22d}
}
Cite this
MLA
Copy
Gorkun, Anastasiya, et al. “Angiogenic potential of spheroids from umbilical cord and adipose-derived multipotent mesenchymal stromal cells within fibrin gel.” Biomedical Materials (Bristol), vol. 13, no. 4, May. 2018, p. 44108. https://iopscience.iop.org/article/10.1088/1748-605X/aac22d.