International Immunology, volume 15, issue 2, pages 187-195
Evidence to support the cellular mechanism involved in serum IgG homeostasis in humans
Publication type: Journal Article
Publication date: 2003-02-01
Journal:
International Immunology
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor: 4.4
ISSN: 09538178, 14602377
General Medicine
Immunology
Immunology and Allergy
Abstract
IgG is the most abundant serum antibody and is an essential component of the humoral immune response. It is known that the 'neonatal' Fc receptor (FcRn) plays a role in maintaining constant serum IgG levels by acting as a protective receptor which binds and salvages IgG from degradation. However, the cellular mechanism that is involved in serum IgG homeostasis is poorly understood. In the current study we address this issue by analyzing the intracellular fate in human endothelial cells of IgG molecules which bind with different affinities to FcRn. The studies show that IgG which do not bind to FcRn accumulate in the lysosomal pathway, providing a cellular explanation for short serum persistence of such antibodies. We have also investigated the saturability of the homeostatic system and find that it has limited capacity. Our observations have direct relevance to the understanding and treatment of IgG deficiency, and to the effective application of therapeutic antibodies.
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5
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Ward E. S. Evidence to support the cellular mechanism involved in serum IgG homeostasis in humans // International Immunology. 2003. Vol. 15. No. 2. pp. 187-195.
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Ward E. S. Evidence to support the cellular mechanism involved in serum IgG homeostasis in humans // International Immunology. 2003. Vol. 15. No. 2. pp. 187-195.
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TY - JOUR
DO - 10.1093/intimm/dxg018
UR - https://doi.org/10.1093/intimm/dxg018
TI - Evidence to support the cellular mechanism involved in serum IgG homeostasis in humans
T2 - International Immunology
AU - Ward, E. S.
PY - 2003
DA - 2003/02/01 00:00:00
PB - Oxford University Press
SP - 187-195
IS - 2
VL - 15
SN - 0953-8178
SN - 1460-2377
ER -
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@article{2003_Ward,
author = {E. S. Ward},
title = {Evidence to support the cellular mechanism involved in serum IgG homeostasis in humans},
journal = {International Immunology},
year = {2003},
volume = {15},
publisher = {Oxford University Press},
month = {feb},
url = {https://doi.org/10.1093/intimm/dxg018},
number = {2},
pages = {187--195},
doi = {10.1093/intimm/dxg018}
}
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MLA
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Ward, E. S.. “Evidence to support the cellular mechanism involved in serum IgG homeostasis in humans.” International Immunology, vol. 15, no. 2, Feb. 2003, pp. 187-195. https://doi.org/10.1093/intimm/dxg018.