Rheumatology

The clinical assessment of lung involvement in patients with Still’s disease, results from the multicentre international AIDA Network Still's Disease Registry

Piero Ruscitti ^{1, 2}

Antonio Vitale ^{3, 4, 5, 6}

Ilenia Di Cola ²

Valeria Caggiano ^{3, 4, 5, 6}

Pierpaolo Palumbo ⁷

Ernesto Di Cesare ^{1, 2}

Andrea Hinojosa-Azaola ⁸

Jiram Torres-Ruiz ^{8, 9}

Guillermo Arturo Guaracha-Basañez ⁹

Guillermo A. Guaracha-Basáñez ⁸

Eduardo Martín-Nares ⁸

Giuseppe Lopalco ^{10, 11}

Maria Morrone ^{10, 11}

Florenzo Iannone ¹¹

Henrique A Mayrink Giardini ¹²

Henrique Ayres Mayrink Giardini ¹³

Rafael Alves Cordeiro ¹³

Isabele Parente de Brito Antonelli ^{12, 13}

Onorina Berardicurti ^{14, 15}

Luca Navarini ^{14, 15, 16, 17}

Francesco Ciccia ¹⁸

Maria Chiara Visconti ^{18, 19}

Daniela Iacono ^{18, 19}

Haner Direskeneli ^{20, 21}

Sukran Erten ^{22, 23}

Haihong Yao ^{24, 25, 26}

Maissa Thabet ^{27, 28}

Samar Tharwat ^{29, 30, 31, 32}

Gaafar Ragab ^{33, 34}

Verónica Gómez-Caverzaschi ^{35, 36}

Petros P. Sfikakis ³⁷

P. Sfikakis ³⁸

Lampros Fotis ³⁹

Francesco La Torre ^{40, 41}

Armin Maier ^{42, 43}

Anastasios Karamanakos ^{44, 45}

Ibrahim A Almaghlouth ^{46, 47}

Micol Frassi ^{48, 49}

Abdurrahman Tufan ⁵⁰

Marcello Govoni ^{51, 52}

Jurgen Sota ^{3, 4, 5, 6}

Gabriele Simonini ^{53, 54}

Giacomo Emmi ^{55, 56, 57, 58, 59}

Francesca Li Gobbi ^{60, 61}

Paola Parronchi ⁶²

Stefania Costi ^{63, 64}

Piercarlo Sarzi-Puttini ^{65, 66}

Daniela Opris-Belinski ^{67, 68}

Paolo Sfriso ^{69, 70}

Maria Tarsia ^{3, 4, 5, 6}

Maria Cristina Maggio ^{71, 72}

Sara Monti ^{73, 74, 75, 76}

Özgül Soysal Gündüz ^{77, 78}

Donato Rigante ^{79, 80, 81}

Elena Bartoloni ⁸²

Elena Verrecchia ^{83, 84}

Annamaria Iagnocco ^{85, 86}

Ombretta Viapiana ^{87, 88}

Elena Bargagli ^{4, 6, 89, 90}

Ezgi D Batu ⁹¹

Ezgi Deniz Batu ⁹²

GIAN DOMENICO SEBASTIANI ^{93, 94}

Emanuela del Giudice ⁹⁵

Giovanni Conti ^{96, 97}

Luciana Breda ⁹⁸

L. Breda ⁹⁹

Antonio Gidaro ^{100, 101}

Maria Francesca Gicchino ^{102, 103}

Carla Gaggiano ^{3, 4, 5, 6}

Antonio Luca Brucato ^{104, 105}

Paola Triggianese ^{106, 107, 108}

Joanna Makowska ^{109, 110}

Francesco Carubbi ^{111, 112}

Nicola Farina ^{113, 114}

Giuliana Guggino ¹¹⁵

Amato de Paulis ^{116, 117, 118}

Maria Antonietta Mazzei ^{4, 6, 119, 120}

Nunzia Di Meglio ^{4, 6, 119, 120}

Alberto Lo Gullo ¹²¹

A.L.o Gullo ¹²¹

Alessandro Conforti ^{122, 123}

Benson Ogunjimi ^{124, 125, 126, 127, 128, 129, 130, 131}

Laura Calabrese ^{4, 6, 132, 133, 134, 135}

Pietro Rubegni ^{4, 6, 132, 133, 134, 135}

Annarita Giardina ^{136, 137}

Ewa Wiesik-Szewczyk ¹³⁸

Ewa Więsik-Szewczyk ¹³⁹

Alberto Balistreri ^{4, 6, 140, 141}

Claudia Fabiani ^{4, 6, 142, 143}

Bruno Frediani ^{3, 4, 5, 6}

Lorenzo Dagna ^{113, 114, 144, 145}

Roberto Giacomelli ^{14, 15, 16, 17}

Luca Cantarini ^{5, 6}

Hide authors affiliations Show authors affiliations: 145 affiliations

University of L'Aquila Department of Biotechnological and Applied Clinical Sciences, , L'Aquila, |

Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila , L’Aquila, |

University of Siena Department of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, , Siena, |

⁴

Autoinflammatory and Autoimmune Diseases (RITA) Center] Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, , Siena, |

⁵

Department of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet’s Disease Clinic, University of Siena , Siena, |

⁶

Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center] , Siena, |

⁷

Department of Diagnostic Imaging, Area of Cardiovascular and Interventional Imaging, Abruzzo Health Unit 1 , L’Aquila, |

⁸

Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán , Mexico City, |

⁹

Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Department of Immunology and Rheumatology, , Mexico City, |

¹⁰

University of Bari Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J) Policlinic Hospital, , Bari, |

¹¹

Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J) Policlinic Hospital, University of Bari , Bari, |

¹²

Universidade de São Paulo Rheumatology Division, Faculdade de Medicina, Hospital das Clínicas, , São Paulo, |

¹³

Rheumatology Division, Faculdade de Medicina, Hospital das Clínicas, Universidade de São Paulo , São Paulo, |

¹⁴

Clinical and research section of Rheumatology and Clinical Immunology, Fondazione Policlinico Campus Bio-Medico , Rome, |

¹⁵

Department of Medicine, University of Rome “Campus Biomedico” School of Medicine, Rheumatology, Immunology and Clinical Medicine Unit , Rome, |

¹⁶

Fondazione Policlinico Campus Bio-Medico, Via Álvaro del Portillo 200 Clinical and research section of Rheumatology and Clinical Immunology, , Rome, 00128, |

¹⁷

Rheumatology, Immunology and Clinical Medicine Unit Department of Medicine, University of Rome “Campus Biomedico” School of Medicine, , Rome, |

¹⁸

Department of Precision Medicine, University of Campania “Luigi Vanvitelli” , Naples, |

¹⁹

University of Campania “Luigi Vanvitelli” Department of Precision Medicine, , Naples, |

²⁰

Marmara University, Faculty of Medic Department of Internal Medicine, Division of Rheumatology, , Istanbul, Turkey, ine |

²¹

Department of Internal Medicine, Division of Rheumatology, Faculty of Medic, Marmara University , Istanbul, |

²²

Ankara Yıldırım Beyazıt University Department of Rheumatology, Faculty of Medicine Ankara City Hospital, , Ankara,

Ankara Yildirim Beyazit University

Ankara Bilkent City Hospital

²³

Department of Rheumatology, Faculty of Medicine Ankara City Hospital, Ankara Yıldırım Beyazıt University , Ankara,

Ankara Yildirim Beyazit University

Ankara Bilkent City Hospital

²⁴

and Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135) Department of Rheumatology and Immunology, Peking University People's Hospital, , Beijing, |

²⁵

Department of Rheumatology and Immunology, Peking University People’s Hospital , Beijing, |

²⁶

Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135) , Beijing, |

²⁷

University of Sousse, Faculty of medicine of Sousse Internal medicine department, Farhat Hached University Hospital, , Sousse,

University of Sousse

Hôpital Farhat-Hached de Sousse

²⁸

Internal Medicine Department, Faculty of Medicine of Sousse, Farhat Hached University Hospital, University of Sousse , Sousse,

University of Sousse

Hôpital Farhat-Hached de Sousse

²⁹

Mansoura University Rheumatology and Immunology Unit, Internal Medicine Department, , Mansoura, |

³⁰

Horus University Department of Internal Medicine, Faculty of Medicine, , New Damietta, |

³¹

Rheumatology and Immunology Unit, Internal Medicine Department, Mansoura University , Mansoura, |

³²

Department of Internal Medicine, Faculty of Medicine, Horus University , New Damietta, |

³³

Internal Medicine Department, Rheumatology and Clinical Immunology Unit, Faculty of Medicine, Cairo University , Giza, |

³⁴

Faculty of Medicine, Newgiza University , 6th of October City,

³⁵

Autoinflammatory and Autoimmune Diseases (RITA) Center], University of Barcelona Department of Autoimmune Diseases, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Hospital Clínic of Barcelona [European Reference Network (ERN) for Rare Immunodeficiency, , Barcelona,

Fundació de Recerca Clínic Barcelona-Institut d’Investigacions Biomèdiques August Pi i Sunyer

Hospital Clínic de Barcelona

³⁶

Department of Autoimmune Diseases, Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Hospital Clínic of Barcelona [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], University of Barcelona , Barcelona, |

³⁷

National and Kapodistrian University of Athens Joint Academic Rheumatology Program, Medical School, , Athens, |

³⁸

Joint Academic Rheumatology Program, Medical School, National and Kapodistrian University of Athens , Athens, |

³⁹

Department of Pediatrics, Attikon General Hospital, National and Kapodistrian University of Athens , Athens, |

⁴⁰

Giovanni XXIII Pediatric Hospital, University of Bari Department of Pediatrics, Pediatric Rheumatology Center, , Bari, |

⁴¹

Department of Pediatrics, Pediatric Rheumatology Center, Giovanni XXIII Pediatric Hospital, University of Bari , Bari, |

⁴²

Central Hospital of Bolzano Rheumatology Unit, Department of Medicine, , Bolzano, |

⁴³

Rheumatology Unit, Department of Medicine, Central Hospital of Bolzano , Bolzano, |

⁴⁴

“Evangelismos” General Hospital Department of Rheumatology, , Athens,

⁴⁵

Department of Rheumatology, “Evangelismos” General Hospital , Athens,

⁴⁶

Rheumatology Unit, Department of Medicine, College of Medicine, King Saud University , Riyadh, |

⁴⁷

College of Medicine Research Center, College of Medicine, King Saud University , Riyadh, |

⁴⁸

Autoinflammatory and Autoimmune Diseases (RITA) Center] Rheumatology and Clinical Immunology, Spedali Civili and Department of Clinical and Experimental Sciences, University of Brescia, [European Reference Network (ERN) for Rare Immunodeficiency, , Brescia, |

⁴⁹

Rheumatology and Clinical Immunology, Spedali Civili and Department of Clinical and Experimental Sciences, University of Brescia, [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center] , Brescia, |

⁵⁰

Department of Internal Medicine, Division of Rheumatology, Gazi University Hospital , Ankara, |

⁵¹

University of Ferrara Rheumatology Unit, Department of Medical Sciences, Azienda Ospedaliero-Universitaria S. Anna-Ferrara, , Ferrara, |

⁵²

Rheumatology Unit, Department of Medical Sciences, Azienda Ospedaliero-Universitaria S. Anna-Ferrara, University of Ferrara , Ferrara, |

⁵³

University of Florence NEUROFARBA Department, Rheumatology Unit, Meyer Children's Hospital IRCCS, , Florence,

Istituti di Ricovero e Cura a Carattere Scientifico

University of Florence

⁵⁴

NEUROFARBA Department, Rheumatology Unit, Meyer Children’s Hospital IRCCS, University of Florence , Florence,

Istituti di Ricovero e Cura a Carattere Scientifico

University of Florence

⁵⁵

Cattinara University Hospital Department of Medical, Surgical and Health Sciences, University of Trieste, Italy, and Clinical Medicine and Rheumatology Unit, , Trieste, |

⁵⁶

Monash Medical Centre Centre for Inflammatory Diseases, Monash University Department of Medicine, , Melbourne,

Monash University

Monash Medical Centre

⁵⁷

Department of Medical, Surgical and Health Sciences, University of Trieste , Trieste, |

⁵⁸

Clinical Medicine and Rheumatology Unit, Cattinara University Hospital , Trieste, |

⁵⁹

Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre , Melbourne,

Monash University

Monash Medical Centre

⁶⁰

Azienda USL-Toscana Centro Rheumatology Unit, Hospital S. Giovanni di Dio, , Florence, |

⁶¹

Rheumatology Unit, Hospital S. Giovanni di Dio, Azienda USL-Toscana Centro , Florence, |

⁶²

Department of Experimental and Clinical Medicine, University of Florence , Florence, |

⁶³

Research Center for Adult and Pediatric Rheumatic Diseases, University of Milan Department of Clinical Sciences and Community Health, , Milan, |

⁶⁴

Department of Clinical Sciences and Community Health, Research Center for Adult and Pediatric Rheumatic Diseases, University of Milan , Milan, |

⁶⁵

Università degli Studi di Milano Rheumatology Unit, IRCCS Ospedale Galeazzi—S. Ambrogio, ,

Istituti di Ricovero e Cura a Carattere Scientifico

University of Milan

Galeazzi Orthopaedic Institute

⁶⁶

Rheumatology Unit, IRCCS Ospedale Galeazzi—S. Ambrogio, Università degli Studi di Milano , Milan,

Istituti di Ricovero e Cura a Carattere Scientifico

University of Milan

Galeazzi Orthopaedic Institute

⁶⁷

Carol Davila University of Medicine and Pharmacy Rheumatology and Internal Medicine Department, , Bucharest, |

⁶⁸

Rheumatology and Internal Medicine Department, Carol Davila University of Medicine and Pharmacy , Bucharest, |

⁶⁹

Autoinflammatory and Autoimmune Diseases (RITA) Center] Rheumatology Unit, Department of Medicine, University of Padua, [European Reference Network (ERN) for Rare Immunodeficiency, , Padua, |

⁷⁰

Rheumatology Unit, Department of Medicine, University of Padua, [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center] , Padua, |

⁷¹

Internal Medicine and Medical Specialties (PROMISE) “G. D'Alessandro”, University of Palermo University Department of Health Promotion, Mother and Child Care, , Palermo, |

⁷²

University Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE) “G. D’Alessandro”, University of Palermo , Palermo, |

⁷³

Fondazione IRCCS Policlinico San Matteo Division of Rheumatology, , Pavia, |

⁷⁴

Università di Pavia Department of Internal Medicine and Therapeutics, , |

⁷⁵

Division of Rheumatology, Fondazione IRCCS Policlinico San Matteo , Pavia, |

⁷⁶

Department of Internal Medicine and Therapeutics, Università di Pavia , Pavia, |

⁷⁷

School of Medicine, Manisa Celal Bayar University Division of Rheumatology, Department of Internal Medicine, , Manisa, |

⁷⁸

Division of Rheumatology, Department of Internal Medicine, School of Medicine, Manisa Celal Bayar University , Manisa, |

⁷⁹

Periodic Fever Research Center, Università Cattolica Sacro Cuore Department of Life Sciences and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy, , Rome, |

⁸⁰

Department of Life Sciences and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS , Rome, |

⁸¹

Periodic Fever Research Center, Università Cattolica Sacro Cuore , Rome,

⁸²

Rheumatology Unit, Department of Medicine and Surgery, University of Perugia , Perugia, |

⁸³

Rare Diseases and Periodic Fevers Research Centre, Università Cattolica del Sacro Cuore , Rome, |

⁸⁴

Department of Aging, Neurological, Orthopedic and Head and Neck Sciences, Fondazione Policlinico Universitario Agostino Gemelli Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) , Rome,

Istituti di Ricovero e Cura a Carattere Scientifico

Agostino Gemelli University Polyclinic

⁸⁵

Università degli Studi di Torino Academic Rheumatology Centre, Dipartimento Scienze Cliniche e Biologiche, , Torino, |

⁸⁶

Academic Rheumatology Centre, Dipartimento Scienze Cliniche e Biologiche, Università degli Studi di Torino , Torino, |

⁸⁷

University and Azienda Ospedaliera Universitaria Integrata of Verona Rheumatology Unit, Department of Medicine, , |

⁸⁸

Rheumatology Unit, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona , |

⁸⁹

Surgery and Neurosciences, University of Siena UOC Respiratory Diseases and Lung Transplant, Department Medical Sciences, , Siena, |

⁹⁰

UOC Respiratory Diseases and Lung Transplant, Department Medical Sciences, Surgery and Neurosciences, University of Siena , Siena, |

⁹¹

Faculty of Medicine, Hacettepe University Department of Pediatric Rheumatology, , Ankara, |

⁹²

Faculty of Medicine, Department of Pediatric Rheumatology, Hacettepe University , Ankara, |

⁹³

Azienda Ospedaliera San Camillo Forlanini UOC di Reumatologia, , Roma, |

⁹⁴

UOC di Reumatologia, Azienda Ospedaliera San Camillo Forlanini , Roma, |

⁹⁵

Pediatric and Neonatology Unit, Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome , Latina, |

⁹⁶

Azienda Ospedaliera Universitaria (AOU), “G. Martino” Messina Pediatric Nephrology and Rheumatology Unit, , |

⁹⁷

Pediatric Nephrology and Rheumatology Unit, Azienda Ospedaliera Universitaria (AOU), “G. Martino” Messina , Messina, |

⁹⁸

University of Chieti-Pescara Department of Paediatrics, , Chieti, |

⁹⁹

Department of Paediatrics, University of Chieti-Pescara , Chieti, |

¹⁰⁰

Luigi Sacco Hospital, University of Department of Biomedical and Clinical Sciences Luigi Sacco, , Milan, Italy, Milan |

¹⁰¹

Department of Biomedical and Clinical Sciences Luigi Sacco, Luigi Sacco Hospital, University of Milan , Milan,

University of Milan

Luigi Sacco Hospital

¹⁰²

University of Campania “Luigi Vanvitelli” Department of Woman, Child and of General and Specialized Surgery, , Naples, |

¹⁰³

Department of Woman, Child and of General and Specialized Surgery, University of Campania “Luigi Vanvitelli” , Naples, |

¹⁰⁴

Fatebenefratelli Hospital Pediatric Unit, , Milan, |

¹⁰⁵

Pediatric Unit, Fatebenefratelli Hospital , Milan, |

¹⁰⁶

Rome, Italy; Molecular Medicine and Applied Biotechnology, University of Rome Tor Vergata Rheumatology, Allergology and Clinical Immunology, Department of Systems Medicine, University of Rome Tor Vergata, , Rome, |

¹⁰⁷

Rheumatology, Allergology and Clinical Immunology, Department of Systems Medicine, University of Rome Tor Vergata , Rome, |

¹⁰⁸

Molecular Medicine and Applied Biotechnology, University of Rome Tor Vergata , Rome, |

¹⁰⁹

Medical University of Lodz, Zeromskiego 113, 90-549 Lodz Department of Rheumatology, , |

¹¹⁰

Department of Rheumatology, Medical University of Lodz , Lodz, |

¹¹¹

University of L'Aquila and ASL Avezzano-Sulmona-L'Aquila, San Salvatore Hospital Department of Life, Health & Environmental Sciences and Internal Medicine and Nephrology Unit, Department of Medicine, , L'Aquila, |

¹¹²

Department of Life, Health & Environmental Sciences and Internal Medicine and Nephrology Unit, Department of Medicine, University of L’Aquila and ASL Avezzano-Sulmona-L’Aquila, San Salvatore Hospital , L’Aquila, |

¹¹³

Faculty of Medicine, Università Vita-Salute San Raffaele , Milan, |

¹¹⁴

Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS Ospedale San Raffaele , Milan, |

¹¹⁵

Rheumatology Section, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University Hospital P. Giaccone , Palermo, |

¹¹⁶

Center for Basic and Clinical Immunology Research (CISI), WAO Center of Excellence, University of Naples Federico II Department of Translational Medical Sciences, Section of Clinical Immunology, University of Naples Federico II, Naples, Italy, , Naples, |

¹¹⁷

Department of Translational Medical Sciences, Section of Clinical Immunology, University of Naples Federico II , Naples, |

¹¹⁸

Center for Basic and Clinical Immunology Research (CISI), WAO Center of Excellence, University of Naples Federico II , Naples, |

¹¹⁹

Azienda Ospedaliero-Universitaria Senese Unit of Diagnostic Imaging, Department of Medical, Surgical and Neuro Sciences and of Radiological Sciences, University of Siena, , Siena, 53100, |

¹²⁰

Unit of Diagnostic Imaging, Department of Medical, Surgical and Neuro Sciences and of Radiological Sciences, University of Siena, Azienda Ospedaliero-Universitaria Senese , Siena, |

¹²¹

UOSD Reumatologia, ARNAS Garibaldi , Catania, |

¹²²

Ospedale San Paolo di Civitavecchia, ASL Roma 4, Civitavecchia U.O. Medicina Generale, , Rome,

¹²³

U.O. Medicina Generale, Ospedale San Paolo di Civitavecchia , Rome,

¹²⁴

University of Antwerp Antwerp Unit for Data Analysis and Computation in Immunology and Sequencing, , Antwerp, |

¹²⁵

University of Antwerp Antwerp Center for Translational Immunology and Virology, Vaccine and Infectious Disease Institute, , Antwerp, |

¹²⁶

Antwerp University Hospital Department of Paediatrics, , Antwerp, |

¹²⁷

University of Antwerp Center for Health Economics Research and Modeling Infectious Diseases, Vaccine and Infectious Disease Institute, , Antwerp, |

¹²⁸

Antwerp Unit for Data Analysis and Computation in Immunology and Sequencing, University of Antwerp , Antwerp, |

¹²⁹

Antwerp Center for Translational Immunology and Virology, Vaccine and Infectious Disease Institute, University of Antwerp , Antwerp, |

¹³⁰

Department of Paediatrics, Antwerp University Hospital , Antwerp, |

¹³¹

Center for Health Economics Research and Modeling Infectious Diseases, Vaccine and Infectious Disease Institute, University of Antwerp , Antwerp, |

¹³²

Surgical and Neurological Sciences, University of Siena Dermatology Unit, Department of Medical, , Siena, |

¹³³

Catholic University of the Sacred Heart Institute of Dermatology, , Rome, |

¹³⁴

Dermatology Unit, Department of Medical, Surgical and Neurological Sciences, University of Siena , Siena, |

¹³⁵

Institute of Dermatology, Catholic University of the Sacred Heart , Rome, |

¹³⁶

National Relevance and High Specialization Hospital Trust ARNAS Civico, Di Cristina, Benfratelli Department of Clinical Medicine, Internal Medicine Unit with Rheumatology, Dermatology, Diabetology and Tertiary Diabetic Foot Healthcare, , Palermo, |

¹³⁷

Department of Clinical Medicine, Internal Medicine Unit with Rheumatology, Dermatology, Diabetology and Tertiary Diabetic Foot Healthcare, National Relevance and High Specialization Hospital Trust ARNAS Civico, Di Cristina, Benfratelli , Palermo, |

¹³⁸

Military Institute of Medicine, National Research Institute Department of Internal Medicine, Pneumonology, Allergology and Clinical Immunology, Central Clinical Hospital of the Ministry of National Defense, , Warsaw,

¹³⁹

Department of Internal Medicine, Pneumonology, Allergology and Clinical Immunology, Central Clinical Hospital of the Ministry of National Defense, Military Institute of Medicine, National Research Institute , Warsaw,

¹⁴⁰

University of Siena Bioengineering and Biomedical Data Science Lab, Department of Medical Biotechnologies, , Siena, |

¹⁴¹

Bioengineering and Biomedical Data Science Lab, Department of Medical Biotechnologies, University of Siena , Siena, |

¹⁴²

Surgery and Neurosciences, University of Siena Ophthalmology Unit, Department of Medicine, , |

¹⁴³

Ophthalmology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena , |

¹⁴⁴

Università Vita-Salute San Raffaele Faculty of Medicine, , Milan, |

¹⁴⁵

Allergy and Rare Diseases, IRCCS Ospedale San Raffaele Unit of Immunology, Rheumatology, , Milan, |

Publication type: Journal Article

Publication date: 2025-01-20

Oxford University Press

Rheumatology

scimago Q1

wos Q1

SJR: 1.721

CiteScore: 9.9

Impact factor: 4.4

ISSN: 14620324, 14620332, 14602172

DOI: 10.1093/rheumatology/keaf021

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Abstract

Objectives

To assess the lung involvement in patients with Still’s disease, an inflammatory disease assessing both children and adults. To exploit possible associated factors for parenchymal lung involvement in these patients.

Methods

A multicentre observational study was arranged assessing consecutive patients with Still’s disease characterized by the lung involvement among those included in the AIDA (AutoInflammatory Disease Alliance) Network Still’s Disease Registry. Still’s disease-lung involvement was defined by the presence of pleuritis, parenchymal features, acute respiratory distress syndrome (ARDS), and/or pulmonary arterial hypertension.

Results

In total, 90 patients with Still’s disease and lung involvement were assessed (mean age 36.3 ± 17.8 years, 35.6% male sex). Among them, 13.3% of patients were paediatrics. These patients with lung involvement mainly showed pleuritis in 72.2% of cases, parenchymal features in 34.4%, ARDS in 9.5%, and pulmonary arterial hypertension in 2.3%. After that we focused on patients characterised by parenchymal lung involvement, which is an emergent issue of clinical concern. These patients with parenchymal lung disease were significantly characterized by sore throat, pericarditis, and higher values of systemic score than others. Finally, the administration of both IL-1 or IL-6 inhibitors was not associated with the presence of parenchymal lung involvement.

Conclusion

The clinical characteristics of patients with Still’s disease and lung involvement were described in the AIDA network. We also provided a clinical profile of patients with parenchymal lung involvement considering its prognostic relevance. Although providing a clinical landscape of these patients, further studies are needed to fully clarify this issue.

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Ruscitti P. et al. The clinical assessment of lung involvement in patients with Still’s disease, results from the multicentre international AIDA Network Still's Disease Registry // Rheumatology. 2025.

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@article{2025_Ruscitti,

author = {Piero Ruscitti and Antonio Vitale and Ilenia Di Cola and Valeria Caggiano and Pierpaolo Palumbo and Ernesto Di Cesare and Andrea Hinojosa-Azaola and Jiram Torres-Ruiz and Guillermo Arturo Guaracha-Basañez and Guillermo A. Guaracha-Basáñez and Eduardo Martín-Nares and Giuseppe Lopalco and Maria Morrone and Florenzo Iannone and Henrique A Mayrink Giardini and Henrique Ayres Mayrink Giardini and Rafael Alves Cordeiro and Isabele Parente de Brito Antonelli and Onorina Berardicurti and Luca Navarini and Francesco Ciccia and Maria Chiara Visconti and Daniela Iacono and Haner Direskeneli and Sukran Erten and Haihong Yao and Maissa Thabet and Samar Tharwat and Gaafar Ragab and Verónica Gómez-Caverzaschi and Petros P. Sfikakis and P. Sfikakis and Lampros Fotis and Francesco La Torre and Armin Maier and Anastasios Karamanakos and Ibrahim A Almaghlouth and Micol Frassi and Abdurrahman Tufan and Marcello Govoni and Jurgen Sota and Gabriele Simonini and Giacomo Emmi and Francesca Li Gobbi and Paola Parronchi and Stefania Costi and Piercarlo Sarzi-Puttini and Daniela Opris-Belinski and Paolo Sfriso and Maria Tarsia and others},

title = {The clinical assessment of lung involvement in patients with Still’s disease, results from the multicentre international AIDA Network Still's Disease Registry},

journal = {Rheumatology},

year = {2025},

publisher = {Oxford University Press},

month = {jan},

url = {https://academic.oup.com/rheumatology/advance-article/doi/10.1093/rheumatology/keaf021/7964734},

doi = {10.1093/rheumatology/keaf021}

}

Publisher

Oxford University Press

Journal

Rheumatology

scimago Q1

wos Q1

SJR

1.721

CiteScore

9.9

Impact factor

4.4

ISSN

14620324 (Print)

14620332 (Electronic)

14602172 (Electronic)

Profiles