Plasma Levels of Polyols Erythritol, Mannitol, and Sorbitol and Incident Coronary Heart Disease Among Women
Background and Aims
Erythritol, a sugar alcohol (polyol), has recently been linked to the risks of major adverse cardiovascular events. We investigated whether plasma erythritol and other polyols (mannitol/sorbitol) were associated with the risk of incident coronary heart disease (CHD).
Methods
This prospective nested case-control study included 762 incident cases of CHD and 762 controls from the Nurses’ Health Study. Plasma concentrations of polyols were measured at baseline (1989-90 or 2000-02). Associations of erythritol with cardiometabolic risk factors were also analyzed in the Women’s Lifestyle Validation Study (n=728; blood collected in 2010-12).
Results
Higher erythritol levels were related to more adverse cardiometabolic risk factor status. The relative risk (RR) for CHD per 1-SD increment was 1.15 [95% CI: 1.04, 1.28] for erythritol and 1.16 [1.05, 1.28] for mannitol/sorbitol, after adjusting for diet quality, lifestyles, and adiposity. Compared with women in the lowest quartile, those in the highest quartile (Q4) of erythritol had a RR 1.55 [1.13, 2.14] for CHD. The RR in Q4 of erythritol was 1.61 [1.15, 2.24; p=0.006] when hypertension and dyslipidemia were further added to the model; the RR was 1.21 [0.86, 1.70] after adjustment for diabetes. For mannitol/sorbitol, the RR in the Q4 was 1.42 [1.05, 1.91; p=0.022] for CHD in the multivariable-adjusted model including diabetes.
Conclusions
Higher plasma erythritol and mannitol/sorbitol were related to elevated risks of CHD even after adjustment for diet, lifestyles, adiposity, and other risk factors. The unfavorable association of mannitol/sorbitol, but not erythritol, with CHD risk remained significant independently of diabetes/hyperglycemia.
Top-30
Journals
|
1
|
|
|
European Journal of Preventive Cardiology
1 publication, 14.29%
|
|
|
Aktuelle Kardiologie
1 publication, 14.29%
|
|
|
Foods
1 publication, 14.29%
|
|
|
Medicine (United States)
1 publication, 14.29%
|
|
|
Cell Biochemistry and Function
1 publication, 14.29%
|
|
|
Cardiovascular Diabetology – Endocrinology Reports
1 publication, 14.29%
|
|
|
1
|
Publishers
|
1
|
|
|
Oxford University Press
1 publication, 14.29%
|
|
|
Georg Thieme Verlag KG
1 publication, 14.29%
|
|
|
Cold Spring Harbor Laboratory
1 publication, 14.29%
|
|
|
MDPI
1 publication, 14.29%
|
|
|
Ovid Technologies (Wolters Kluwer Health)
1 publication, 14.29%
|
|
|
Wiley
1 publication, 14.29%
|
|
|
Springer Nature
1 publication, 14.29%
|
|
|
1
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.