Open Access
Translation at first sight: The influence of leading codons
Тип публикации: Journal Article
Дата публикации: 2020-05-19
scimago Q1
wos Q1
БС1
SJR: 7.776
CiteScore: 31.7
Impact factor: 13.1
ISSN: 03051048, 13624962
PubMed ID:
32427319
Genetics
Краткое описание
First triplets of mRNA coding region affect the yield of translation. We have applied the flowseq method to analyze >30 000 variants of the codons 2–11 of the fluorescent protein reporter to identify factors affecting the protein synthesis. While the negative influence of mRNA secondary structure on translation has been confirmed, a positive role of rare codons at the beginning of a coding sequence for gene expression has not been observed. The identity of triplets proximal to the start codon contributes more to the protein yield then more distant ones. Additional in-frame start codons enhance translation, while Shine–Dalgarno-like motifs downstream the initiation codon are inhibitory. The metabolic cost of amino acids affects the yield of protein in the poor medium. The most efficient translation was observed for variants with features resembling those of native Escherichia coli genes.
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ГОСТ
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Osterman I. A. et al. Translation at first sight: The influence of leading codons // Nucleic Acids Research. 2020. Vol. 48. No. 12. pp. 6931-6942.
ГОСТ со всеми авторами (до 50)
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Osterman I. A., Chervontseva Z., Komarova E. S., Zatsepin T. S., Kabilov M. R., GELFAND M. J., Chervontseva Z. S., Evfratov S. A., Sorokina A. V., Rodin V. A., Rubtsova M., Bogdanov A., Gelfand M. S., Dontsova O. A., Sergiev P. V. Translation at first sight: The influence of leading codons // Nucleic Acids Research. 2020. Vol. 48. No. 12. pp. 6931-6942.
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TY - JOUR
DO - 10.1093/nar/gkaa430
UR - https://academic.oup.com/nar/article/48/12/6931/5840581
TI - Translation at first sight: The influence of leading codons
T2 - Nucleic Acids Research
AU - Osterman, Ilya A
AU - Chervontseva, Zoe
AU - Komarova, Ekaterina S
AU - Zatsepin, Timofei S.
AU - Kabilov, Marsel R.
AU - GELFAND, MICHAEL J.
AU - Chervontseva, Zoe S.
AU - Evfratov, Sergey A
AU - Sorokina, Alena V
AU - Rodin, Vladimir A.
AU - Rubtsova, Maria
AU - Bogdanov, Alexey
AU - Gelfand, Mikhail S.
AU - Dontsova, Olga A.
AU - Sergiev, Petr V.
PY - 2020
DA - 2020/05/19
PB - Oxford University Press
SP - 6931-6942
IS - 12
VL - 48
PMID - 32427319
SN - 0305-1048
SN - 1362-4962
ER -
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BibTex (до 50 авторов)
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@article{2020_Osterman,
author = {Ilya A Osterman and Zoe Chervontseva and Ekaterina S Komarova and Timofei S. Zatsepin and Marsel R. Kabilov and MICHAEL J. GELFAND and Zoe S. Chervontseva and Sergey A Evfratov and Alena V Sorokina and Vladimir A. Rodin and Maria Rubtsova and Alexey Bogdanov and Mikhail S. Gelfand and Olga A. Dontsova and Petr V. Sergiev},
title = {Translation at first sight: The influence of leading codons},
journal = {Nucleic Acids Research},
year = {2020},
volume = {48},
publisher = {Oxford University Press},
month = {may},
url = {https://academic.oup.com/nar/article/48/12/6931/5840581},
number = {12},
pages = {6931--6942},
doi = {10.1093/nar/gkaa430}
}
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MLA
Скопировать
Osterman, Ilya A., et al. “Translation at first sight: The influence of leading codons.” Nucleic Acids Research, vol. 48, no. 12, May. 2020, pp. 6931-6942. https://academic.oup.com/nar/article/48/12/6931/5840581.