Open Access
Nucleic Acids Research, volume 48, issue 14, pages 8022-8034
METTL15 interacts with the assembly intermediate of murine mitochondrial small ribosomal subunit to form m4C840 12S rRNA residue
Laptev Ivan G.
1, 2, 3
,
Shvetsova Ekaterina
4
,
Levitskii Sergey
5
,
Serebryakova M. V.
1, 3
,
Rubtsova Maria
2, 3
,
Zgoda Victor
6
,
Bogdanov Alexey
1, 2
,
Kamenski Piotr
5
,
Sergiev Petr V.
1, 2, 3, 7
,
Dontsova Olga
1, 2, 3, 8
Publication type: Journal Article
Publication date: 2020-06-23
Journal:
Nucleic Acids Research
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 14.9
ISSN: 03051048, 13624962
PubMed ID:
32573735
Genetics
Abstract
Mammalian mitochondrial ribosomes contain a set of modified nucleotides, which is distinct from that of the cytosolic ribosomes. Nucleotide m4C840 of the murine mitochondrial 12S rRNA is equivalent to the dimethylated m4Cm1402 residue of Escherichia coli 16S rRNA. Here we demonstrate that mouse METTL15 protein is responsible for the formation of m4C residue of the 12S rRNA. Inactivation of Mettl15 gene in murine cell line perturbs the composition of mitochondrial protein biosynthesis machinery. Identification of METTL15 interaction partners revealed that the likely substrate for this RNA methyltransferase is an assembly intermediate of the mitochondrial small ribosomal subunit containing an assembly factor RBFA.
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1 publication, 4.35%
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Taylor & Francis
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Taylor & Francis
1 publication, 4.35%
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Proceedings of the National Academy of Sciences (PNAS)
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Proceedings of the National Academy of Sciences (PNAS)
1 publication, 4.35%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Laptev I. G. et al. METTL15 interacts with the assembly intermediate of murine mitochondrial small ribosomal subunit to form m4C840 12S rRNA residue // Nucleic Acids Research. 2020. Vol. 48. No. 14. pp. 8022-8034.
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Laptev I. G., Shvetsova E., Levitskii S., Serebryakova M. V., Rubtsova M., Zgoda V., Bogdanov A., Kamenski P., Sergiev P. V., Dontsova O. METTL15 interacts with the assembly intermediate of murine mitochondrial small ribosomal subunit to form m4C840 12S rRNA residue // Nucleic Acids Research. 2020. Vol. 48. No. 14. pp. 8022-8034.
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TY - JOUR
DO - 10.1093/nar/gkaa522
UR - https://doi.org/10.1093%2Fnar%2Fgkaa522
TI - METTL15 interacts with the assembly intermediate of murine mitochondrial small ribosomal subunit to form m4C840 12S rRNA residue
T2 - Nucleic Acids Research
AU - Shvetsova, Ekaterina
AU - Levitskii, Sergey
AU - Bogdanov, Alexey
AU - Sergiev, Petr V.
AU - Dontsova, Olga
AU - Rubtsova, Maria
AU - Laptev, Ivan G.
AU - Serebryakova, M. V.
AU - Zgoda, Victor
AU - Kamenski, Piotr
PY - 2020
DA - 2020/06/23 00:00:00
PB - Oxford University Press
SP - 8022-8034
IS - 14
VL - 48
PMID - 32573735
SN - 0305-1048
SN - 1362-4962
ER -
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@article{2020_Laptev,
author = {Ekaterina Shvetsova and Sergey Levitskii and Alexey Bogdanov and Petr V. Sergiev and Olga Dontsova and Maria Rubtsova and Ivan G. Laptev and M. V. Serebryakova and Victor Zgoda and Piotr Kamenski},
title = {METTL15 interacts with the assembly intermediate of murine mitochondrial small ribosomal subunit to form m4C840 12S rRNA residue},
journal = {Nucleic Acids Research},
year = {2020},
volume = {48},
publisher = {Oxford University Press},
month = {jun},
url = {https://doi.org/10.1093%2Fnar%2Fgkaa522},
number = {14},
pages = {8022--8034},
doi = {10.1093/nar/gkaa522}
}
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MLA
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Laptev, Ivan G., et al. “METTL15 interacts with the assembly intermediate of murine mitochondrial small ribosomal subunit to form m4C840 12S rRNA residue.” Nucleic Acids Research, vol. 48, no. 14, Jun. 2020, pp. 8022-8034. https://doi.org/10.1093%2Fnar%2Fgkaa522.