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Nucleic Acids Research, том 48, издание 14, номера страниц: 8022-8034

METTL15 interacts with the assembly intermediate of murine mitochondrial small ribosomal subunit to form m4C840 12S rRNA residue

Laptev Ivan 1, 2, 3
Shvetsova Ekaterina 4
Levitskii Sergey 5
Serebryakova Marina 1, 3
Rubtsova Maria 1, 2
Zgoda Victor 6
Bogdanov Alexey 2, 3
Kamenski Piotr 5
Sergiev Petr V. 1, 2, 3, 7
Dontsova Olga 1, 2, 3, 8
Тип документаJournal Article
Дата публикации2020-06-23
ИздательOxford University Press
Название журналаNucleic Acids Research
Квартиль по SCImagoQ1
Квартиль по Web of ScienceQ1
Импакт-фактор 202119.16
ISSN03051048, 13624962
Genetics
Краткое описание

Mammalian mitochondrial ribosomes contain a set of modified nucleotides, which is distinct from that of the cytosolic ribosomes. Nucleotide m4C840 of the murine mitochondrial 12S rRNA is equivalent to the dimethylated m4Cm1402 residue of Escherichia coli 16S rRNA. Here we demonstrate that mouse METTL15 protein is responsible for the formation of m4C residue of the 12S rRNA. Inactivation of Mettl15 gene in murine cell line perturbs the composition of mitochondrial protein biosynthesis machinery. Identification of METTL15 interaction partners revealed that the likely substrate for this RNA methyltransferase is an assembly intermediate of the mitochondrial small ribosomal subunit containing an assembly factor RBFA.

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ГОСТ |
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1. Laptev I. и др. METTL15 interacts with the assembly intermediate of murine mitochondrial small ribosomal subunit to form m4C840 12S rRNA residue // Nucleic Acids Research. 2020. Т. 48. № 14. С. 8022–8034.
RIS |
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TY - JOUR

DO - 10.1093/nar/gkaa522

UR - http://dx.doi.org/10.1093/nar/gkaa522

TI - METTL15 interacts with the assembly intermediate of murine mitochondrial small ribosomal subunit to form m4C840 12S rRNA residue

T2 - Nucleic Acids Research

AU - Laptev, Ivan

AU - Shvetsova, Ekaterina

AU - Levitskii, Sergey

AU - Serebryakova, Marina

AU - Rubtsova, Maria

AU - Zgoda, Victor

AU - Bogdanov, Alexey

AU - Kamenski, Piotr

AU - Sergiev, Petr

AU - Dontsova, Olga

PY - 2020

DA - 2020/06/23

PB - Oxford University Press (OUP)

SP - 8022-8034

IS - 14

VL - 48

SN - 0305-1048

SN - 1362-4962

ER -

BibTex |
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@article{2020,

doi = {10.1093/nar/gkaa522},

url = {https://doi.org/10.1093%2Fnar%2Fgkaa522},

year = 2020,

month = {jun},

publisher = {Oxford University Press ({OUP})},

volume = {48},

number = {14},

pages = {8022--8034},

author = {Ivan Laptev and Ekaterina Shvetsova and Sergey Levitskii and Marina Serebryakova and Maria Rubtsova and Victor Zgoda and Alexey Bogdanov and Piotr Kamenski and Petr Sergiev and Olga Dontsova},

title = {{METTL}15 interacts with the assembly intermediate of murine mitochondrial small ribosomal subunit to form m4C840 12S {rRNA} residue}

}

MLA
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Laptev, Ivan et al. “METTL15 Interacts with the Assembly Intermediate of Murine Mitochondrial Small Ribosomal Subunit to Form m4C840 12S rRNA Residue.” Nucleic Acids Research 48.14 (2020): 8022–8034. Crossref. Web.