Open Access
antiSMASH 6.0: improving cluster detection and comparison capabilities
Тип публикации: Journal Article
Дата публикации: 2021-05-12
SCImago Q1
Tоп 10% SCImago
WOS Q1
БС1
SJR: 8.111
CiteScore: 29.8
Impact factor: 15
ISSN: 03051048, 13624962
PubMed ID:
33978755
Genetics
Краткое описание
Abstract Many microorganisms produce natural products that form the basis of antimicrobials, antivirals, and other drugs. Genome mining is routinely used to complement screening-based workflows to discover novel natural products. Since 2011, the "antibiotics and secondary metabolite analysis shell—antiSMASH" (https://antismash.secondarymetabolites.org/) has supported researchers in their microbial genome mining tasks, both as a free-to-use web server and as a standalone tool under an OSI-approved open-source license. It is currently the most widely used tool for detecting and characterising biosynthetic gene clusters (BGCs) in bacteria and fungi. Here, we present the updated version 6 of antiSMASH. antiSMASH 6 increases the number of supported cluster types from 58 to 71, displays the modular structure of multi-modular BGCs, adds a new BGC comparison algorithm, allows for the integration of results from other prediction tools, and more effectively detects tailoring enzymes in RiPP clusters.
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Blin K. et al. antiSMASH 6.0: improving cluster detection and comparison capabilities // Nucleic Acids Research. 2021. Vol. 49. No. W1. p. W29-W35.
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Blin K., Shaw S., Kloosterman A. M., Charlop Powers Z., van Wezel G. P., Medema M. H., Weber T. antiSMASH 6.0: improving cluster detection and comparison capabilities // Nucleic Acids Research. 2021. Vol. 49. No. W1. p. W29-W35.
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TY - JOUR
DO - 10.1093/nar/gkab335
UR - https://doi.org/10.1093/nar/gkab335
TI - antiSMASH 6.0: improving cluster detection and comparison capabilities
T2 - Nucleic Acids Research
AU - Blin, Kai
AU - Shaw, Simon
AU - Kloosterman, Alexander M
AU - Charlop Powers, Zach
AU - van Wezel, Gilles P.
AU - Medema, Marnix H.
AU - Weber, Tilmann
PY - 2021
DA - 2021/05/12
PB - Oxford University Press
SP - W29-W35
IS - W1
VL - 49
PMID - 33978755
SN - 0305-1048
SN - 1362-4962
ER -
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@article{2021_Blin,
author = {Kai Blin and Simon Shaw and Alexander M Kloosterman and Zach Charlop Powers and Gilles P. van Wezel and Marnix H. Medema and Tilmann Weber},
title = {antiSMASH 6.0: improving cluster detection and comparison capabilities},
journal = {Nucleic Acids Research},
year = {2021},
volume = {49},
publisher = {Oxford University Press},
month = {may},
url = {https://doi.org/10.1093/nar/gkab335},
number = {W1},
pages = {W29--W35},
doi = {10.1093/nar/gkab335}
}
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Blin, Kai, et al. “antiSMASH 6.0: improving cluster detection and comparison capabilities.” Nucleic Acids Research, vol. 49, no. W1, May. 2021, pp. W29-W35. https://doi.org/10.1093/nar/gkab335.
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