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, том 40 , издание 21 , страницы 10689-10700

The DUBm subunit Sgf11 is required for mRNA export and interacts with Cbp80 in Drosophila

Dmitriy Gurskiy ¹

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Department of Regulation of Gene Expression, Institute of Gene Biology, Russian Academy of Sciences, Vavilov Street 32, Moscow 119991, Russia. |

Тип публикации: Journal Article

Дата публикации: 2012-09-18

Oxford University Press

Nucleic Acids Research

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CiteScore: 31.7

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ISSN: 03051048, 13624962

DOI: 10.1093/nar/gks857

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PubMed ID: 22989713

Genetics

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SAGA/TFTC is a histone acetyltransferase complex that has a second enzymatic activity because of the presence of a deubiquitination module (DUBm). Drosophila DUBm consists of Sgf11, ENY2 and Nonstop proteins. We show that Sgf11 has other DUBm-independent functions. It associates with Cbp80 component of the cap-binding complex and is thereby recruited onto growing messenger ribonucleic acid (mRNA); it also interacts with the AMEX mRNA export complex and is essential for hsp70 mRNA export, as well as for general mRNA export from the nucleus. Thus, Sgf11 functions as a component of both SAGA DUBm and the mRNA biogenesis machinery.

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Gurskiy D. et al. The DUBm subunit Sgf11 is required for mRNA export and interacts with Cbp80 in Drosophila // Nucleic Acids Research. 2012. Vol. 40. No. 21. pp. 10689-10700.

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Gurskiy D. The DUBm subunit Sgf11 is required for mRNA export and interacts with Cbp80 in Drosophila // Nucleic Acids Research. 2012. Vol. 40. No. 21. pp. 10689-10700.

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TY - JOUR

DO - 10.1093/nar/gks857

UR - https://doi.org/10.1093/nar/gks857

TI - The DUBm subunit Sgf11 is required for mRNA export and interacts with Cbp80 in Drosophila

T2 - Nucleic Acids Research

AU - Gurskiy, Dmitriy

PY - 2012

DA - 2012/09/18

PB - Oxford University Press

SP - 10689-10700

IS - 21

VL - 40

PMID - 22989713

SN - 0305-1048

SN - 1362-4962

ER -

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@article{2012_Gurskiy,

author = {Dmitriy Gurskiy},

title = {The DUBm subunit Sgf11 is required for mRNA export and interacts with Cbp80 in Drosophila},

journal = {Nucleic Acids Research},

year = {2012},

volume = {40},

publisher = {Oxford University Press},

month = {sep},

url = {https://doi.org/10.1093/nar/gks857},

number = {21},

pages = {10689--10700},

doi = {10.1093/nar/gks857}

}

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Gurskiy, Dmitriy, et al. “The DUBm subunit Sgf11 is required for mRNA export and interacts with Cbp80 in Drosophila.” Nucleic Acids Research, vol. 40, no. 21, Sep. 2012, pp. 10689-10700. https://doi.org/10.1093/nar/gks857.