Open Access
Nucleic Acids Research, volume 42, issue 15, pages 9531-9542
Chimeric bifunctional oligonucleotides as a novel tool to invade telomerase assembly
Publication type: Journal Article
Publication date: 2014-07-31
Journal:
Nucleic Acids Research
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 14.9
ISSN: 03051048, 13624962
PubMed ID:
25081209
Genetics
Abstract
Telomerase is a key participant in the telomere length maintaining system in eukaryotic cells. Telomerase RNA and protein reverse transcriptase subunits are essential for the appearance of active telomerase in vitro. Telomerase is active in many cancer types and is a potential target for anticancer drug development. Here we report a new approach for impairing telomerase function at the stage of human telomerase assembly. The approach is based on the application of chimeric bifunctional oligonucleotides that contain two oligonucleotide parts complementary to the functional domains of telomerase RNA connected with non-nucleotide linkers in different orientations (5′-3′, 5′-5′ or 3′-3′). Such chimeras inhibited telomerase in vitro in the nM range, but were effective in vivo in sub-nM concentrations, predominantly due to their effect on telomerase assembly and dimerization.
Citations by journals
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1
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Nucleic Acids Research
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1 publication, 11.11%
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Oncotarget
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1 publication, 11.11%
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Journal of Molecular Recognition
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Journal of Molecular Recognition
1 publication, 11.11%
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Biochemistry (Moscow)
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1 publication, 11.11%
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Frontiers in Cell and Developmental Biology
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1 publication, 11.11%
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PLoS ONE
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1 publication, 11.11%
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Pharmacology and Therapeutics
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1 publication, 11.11%
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Medicinal Research Reviews
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1 publication, 11.11%
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Molecular Biology
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1 publication, 11.11%
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1
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Citations by publishers
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1
2
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Wiley
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Wiley
2 publications, 22.22%
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Pleiades Publishing
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Pleiades Publishing
2 publications, 22.22%
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Oxford University Press
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Oxford University Press
1 publication, 11.11%
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Impact Journals
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Impact Journals
1 publication, 11.11%
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Frontiers Media S.A.
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Frontiers Media S.A.
1 publication, 11.11%
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Public Library of Science (PLoS)
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Public Library of Science (PLoS)
1 publication, 11.11%
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Elsevier
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Elsevier
1 publication, 11.11%
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1
2
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Azhibek D. M. et al. Chimeric bifunctional oligonucleotides as a novel tool to invade telomerase assembly // Nucleic Acids Research. 2014. Vol. 42. No. 15. pp. 9531-9542.
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Azhibek D. M., Zvereva M., Zatsepin T. S., Rubtsova M., Dontsova O. Chimeric bifunctional oligonucleotides as a novel tool to invade telomerase assembly // Nucleic Acids Research. 2014. Vol. 42. No. 15. pp. 9531-9542.
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TY - JOUR
DO - 10.1093/nar/gku688
UR - https://doi.org/10.1093%2Fnar%2Fgku688
TI - Chimeric bifunctional oligonucleotides as a novel tool to invade telomerase assembly
T2 - Nucleic Acids Research
AU - Zvereva, Maria
AU - Dontsova, Olga
AU - Azhibek, Dulat M
AU - Zatsepin, Timofei S.
AU - Rubtsova, Maria
PY - 2014
DA - 2014/07/31 00:00:00
PB - Oxford University Press
SP - 9531-9542
IS - 15
VL - 42
PMID - 25081209
SN - 0305-1048
SN - 1362-4962
ER -
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@article{2014_Azhibek,
author = {Maria Zvereva and Olga Dontsova and Dulat M Azhibek and Timofei S. Zatsepin and Maria Rubtsova},
title = {Chimeric bifunctional oligonucleotides as a novel tool to invade telomerase assembly},
journal = {Nucleic Acids Research},
year = {2014},
volume = {42},
publisher = {Oxford University Press},
month = {jul},
url = {https://doi.org/10.1093%2Fnar%2Fgku688},
number = {15},
pages = {9531--9542},
doi = {10.1093/nar/gku688}
}
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MLA
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Azhibek, Dulat M., et al. “Chimeric bifunctional oligonucleotides as a novel tool to invade telomerase assembly.” Nucleic Acids Research, vol. 42, no. 15, Jul. 2014, pp. 9531-9542. https://doi.org/10.1093%2Fnar%2Fgku688.