Open Access
Open access
Nucleic Acids Research, том 46, издание 17, номера страниц: 8966-8977

Protein encoded in human telomerase RNA is involved in cell protective pathways

Rubtsova Maria 1, 2
Naraykina Yulia 1, 3
Meerson Mark 3
Prassolov Vladimir 4
Lazarev Vasily 5
Manuvera Valentin 5
Kovalchuk Sergey 6
Anikanov Nickolay 5
Butenko Ivan 5
Pobeguts Olga 5
Govorun Vadim 5
Dontsova Olga 1, 2, 6
Тип документаJournal Article
Дата публикации2018-08-08
ИздательOxford University Press
Название журналаNucleic Acids Research
Квартиль по SCImagoQ1
Квартиль по Web of ScienceQ1
Импакт-фактор 202119.16
ISSN03051048, 13624962
Краткое описание
Abstract Several studies have described functional peptides encoded in RNA that are considered to be noncoding. Telomerase RNA together with telomerase reverse transcriptase and regulatory proteins make up the telomerase complex, the major component of the telomere length-maintaining machinery. In contrast to protein subunits, telomerase RNA is expressed constitutively in most somatic cells where telomerase reverse transcriptase is absent. We show here that the transcript of human telomerase RNA codes a 121 amino acid protein (hTERP). The existence of hTERP was shown by immunoblotting, immunofluorescence microscopy and mass spectroscopy. Gain-of-function and loss-of-function experiments showed that hTERP protects cells from drug-induced apoptosis and participates in the processing of autophagosome. We suggest that hTERP regulates crosstalk between autophagy and apoptosis and is involved in cellular adaptation under stress conditions.
Пристатейные ссылки: 58
Цитируется в публикациях: 28
Telomerase and mTOR in the brain: the mitochondria connection
Saretzki G., Miwa S.
Q1 Neural Regeneration Research 2017 цитирований: 14
Open Access
Open access
mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide
Matsumoto A., Pasut A., Matsumoto M., Yamashita R., Fung J., Monteleone E., Saghatelian A., Nakayama K.I., Clohessy J.G., Pandolfi P.P.
Q1 Nature 2016 цитирований: 374
Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family
Li X., Tran K.M., Aziz K.E., Sorokin A.V., Chen J., Wang W.
Q1 Molecular and Cellular Proteomics 2016 цитирований: 23
Open Access
Open access
Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects
Shukla S., Schmidt J.C., Goldfarb K.C., Cech T.R., Parker R.
Q1 Nature Structural and Molecular Biology 2016 цитирований: 75
Open Access
Open access
A peptide encoded by a transcript annotated as long noncoding RNA enhances SERCA activity in muscle
Nelson B.R., Makarewich C.A., Anderson D.M., Winders B.R., Troupes C.D., Wu F., Reese A.L., McAnally J.R., Chen X., Kavalali E.T., Cannon S.C., Houser S.R., Bassel-Duby R., Olson E.N.
Q1 Science 2016 цитирований: 487
Open Access
Open access
A Polyadenylation-Dependent 3′ End Maturation Pathway Is Required for the Synthesis of the Human Telomerase RNA
Nguyen D., Grenier St-Sauveur V., Bergeron D., Dupuis-Sandoval F., Scott M., Bachand F.
Q1 Cell Reports 2015 цитирований: 70
Open Access
Open access
Human Telomerase RNA Processing and Quality Control
Tseng C., Wang H., Burns A., Schroeder M., Gaspari M., Baumann P.
Q1 Cell Reports 2015 цитирований: 82
Open Access
Open access
2016 update of the PRIDE database and its related tools
Vizcaíno J.A., Csordas A., del-Toro N., Dianes J.A., Griss J., Lavidas I., Mayer G., Perez-Riverol Y., Reisinger F., Ternent T., Xu Q., Wang R., Hermjakob H.
Q1 Nucleic Acids Research 2015 цитирований: 2403
Open Access
Open access
Telomerase deficiency delays renal recovery in mice after ischemia–reperfusion injury by impairing autophagy
Cheng H., Fan X., Lawson W.E., Paueksakon P., Harris R.C.
Q1 Kidney International 2015 цитирований: 45
Open Access
Open access
A Micropeptide Encoded by a Putative Long Noncoding RNA Regulates Muscle Performance
Anderson D., Anderson K., Chang C., Makarewich C., Nelson B., McAnally J., Kasaragod P., Shelton J., Liou J., Bassel-Duby R., Olson E.
Q1 Cell 2015 цитирований: 651
Open Access
Open access
Localization and abundance analysis of human lncRNAs at single-cell and single-molecule resolution
Cabili M.N., Dunagin M.C., McClanahan P.D., Biaesch A., Padovan-Merhar O., Regev A., Rinn J.L., Raj A.
2015 цитирований: 464
Open Access
Open access
Proteomic analyses reveal distinct chromatin‐associated and soluble transcription factor complexes
Li X., Wang W., Wang J., Malovannaya A., Xi Y., Li W., Guerra R., Hawke D.H., Qin J., Chen J.
Q1 Molecular Systems Biology 2015 цитирований: 69
Open Access
Open access
An antiapoptotic role for telomerase RNA in human immune cells independent of telomere integrity or telomerase enzymatic activity
Gazzaniga F.S., Blackburn E.H.
Q1 Blood 2014 цитирований: 51
Open Access
Open access
Proteomic Analysis of the Human Cyclin-dependent Kinase Family Reveals a Novel CDK5 Complex Involved in Cell Growth and Migration
Xu S., Li X., Gong Z., Wang W., Li Y., Nair B.C., Piao H., Yang K., Wu G., Chen J.
Q1 Molecular and Cellular Proteomics 2014 цитирований: 25
Open Access
Open access
Extensive localization of long noncoding RNAs to the cytosol and mono- and polyribosomal complexes
van Heesch S., van Iterson M., Jacobi J., Boymans S., Essers P.B., de Bruijn E., Hao W., MacInnes A.W., Cuppen E., Simonis M.
Q1 Genome Biology 2014 цитирований: 263
Open Access
Open access


1. Rubtsova M. и др. Protein encoded in human telomerase RNA is involved in cell protective pathways // Nucleic Acids Research. 2018. Т. 46. № 17. С. 8966–8977.


DO - 10.1093/nar/gky705

UR -

TI - Protein encoded in human telomerase RNA is involved in cell protective pathways

T2 - Nucleic Acids Research

AU - Rubtsova, Maria

AU - Naraykina, Yulia

AU - Vasilkova, Daria

AU - Meerson, Mark

AU - Zvereva, Maria

AU - Prassolov, Vladimir

AU - Lazarev, Vasily

AU - Manuvera, Valentin

AU - Kovalchuk, Sergey

AU - Anikanov, Nickolay

AU - Butenko, Ivan

AU - Pobeguts, Olga

AU - Govorun, Vadim

AU - Dontsova, Olga

PY - 2018

DA - 2018/08/08

PB - Oxford University Press (OUP)

SP - 8966-8977

IS - 17

VL - 46

SN - 0305-1048

SN - 1362-4962

ER -

BibTex |


doi = {10.1093/nar/gky705},

url = {},

year = 2018,

month = {aug},

publisher = {Oxford University Press ({OUP})},

volume = {46},

number = {17},

pages = {8966--8977},

author = {Maria Rubtsova and Yulia Naraykina and Daria Vasilkova and Mark Meerson and Maria Zvereva and Vladimir Prassolov and Vasily Lazarev and Valentin Manuvera and Sergey Kovalchuk and Nickolay Anikanov and Ivan Butenko and Olga Pobeguts and Vadim Govorun and Olga Dontsova},

title = {Protein encoded in human telomerase {RNA} is involved in cell protective pathways}


Rubtsova, Maria et al. “Protein Encoded in Human Telomerase RNA Is Involved in Cell Protective Pathways.” Nucleic Acids Research 46.17 (2018): 8966–8977. Crossref. Web.