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Nucleic Acids Research, том 46, издание 17, номера страниц: 8966-8977

Protein encoded in human telomerase RNA is involved in cell protective pathways

Rubtsova Maria 1, 2
Naraykina Yulia 1, 3
Meerson Mark 3
Prassolov Vladimir 4
Lazarev Vasily 5
Manuvera Valentin 5
Kovalchuk Sergey 6
Anikanov Nickolay 5
Butenko Ivan 5
Pobeguts Olga 5
Govorun Vadim 5
Dontsova Olga 1, 2, 6
Тип документаJournal Article
Дата публикации2018-08-08
ИздательOxford University Press
Название журналаNucleic Acids Research
Квартиль по SCImagoQ1
Квартиль по Web of ScienceQ1
Импакт-фактор 202119.16
ISSN03051048, 13624962
Genetics
Краткое описание
Abstract Several studies have described functional peptides encoded in RNA that are considered to be noncoding. Telomerase RNA together with telomerase reverse transcriptase and regulatory proteins make up the telomerase complex, the major component of the telomere length-maintaining machinery. In contrast to protein subunits, telomerase RNA is expressed constitutively in most somatic cells where telomerase reverse transcriptase is absent. We show here that the transcript of human telomerase RNA codes a 121 amino acid protein (hTERP). The existence of hTERP was shown by immunoblotting, immunofluorescence microscopy and mass spectroscopy. Gain-of-function and loss-of-function experiments showed that hTERP protects cells from drug-induced apoptosis and participates in the processing of autophagosome. We suggest that hTERP regulates crosstalk between autophagy and apoptosis and is involved in cellular adaptation under stress conditions.
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1. Rubtsova M. и др. Protein encoded in human telomerase RNA is involved in cell protective pathways // Nucleic Acids Research. 2018. Т. 46. № 17. С. 8966–8977.
RIS |
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TY - JOUR

DO - 10.1093/nar/gky705

UR - http://dx.doi.org/10.1093/nar/gky705

TI - Protein encoded in human telomerase RNA is involved in cell protective pathways

T2 - Nucleic Acids Research

AU - Rubtsova, Maria

AU - Naraykina, Yulia

AU - Vasilkova, Daria

AU - Meerson, Mark

AU - Zvereva, Maria

AU - Prassolov, Vladimir

AU - Lazarev, Vasily

AU - Manuvera, Valentin

AU - Kovalchuk, Sergey

AU - Anikanov, Nickolay

AU - Butenko, Ivan

AU - Pobeguts, Olga

AU - Govorun, Vadim

AU - Dontsova, Olga

PY - 2018

DA - 2018/08/08

PB - Oxford University Press (OUP)

SP - 8966-8977

IS - 17

VL - 46

SN - 0305-1048

SN - 1362-4962

ER -

BibTex |
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@article{2018,

doi = {10.1093/nar/gky705},

url = {https://doi.org/10.1093%2Fnar%2Fgky705},

year = 2018,

month = {aug},

publisher = {Oxford University Press ({OUP})},

volume = {46},

number = {17},

pages = {8966--8977},

author = {Maria Rubtsova and Yulia Naraykina and Daria Vasilkova and Mark Meerson and Maria Zvereva and Vladimir Prassolov and Vasily Lazarev and Valentin Manuvera and Sergey Kovalchuk and Nickolay Anikanov and Ivan Butenko and Olga Pobeguts and Vadim Govorun and Olga Dontsova},

title = {Protein encoded in human telomerase {RNA} is involved in cell protective pathways}

}

MLA
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Rubtsova, Maria et al. “Protein Encoded in Human Telomerase RNA Is Involved in Cell Protective Pathways.” Nucleic Acids Research 46.17 (2018): 8966–8977. Crossref. Web.