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Nucleic Acids Research, том 46, издание 17, страницы 8966-8977

Protein encoded in human telomerase RNA is involved in cell protective pathways

Rubtsova Maria 1, 2
Naraykina Yulia 1, 3
Meerson Mark 3
Prassolov Vladimir 4
Lazarev Vasily 5
Manuvera Valentin 5
Anikanov Nickolay 5
Butenko Ivan 5
Pobeguts Olga 5
Govorun Vadim M. 5
Dontsova Olga 1, 2, 6
Тип публикацииJournal Article
Дата публикации2018-08-08
Oxford University Press
Oxford University Press
ЖурналNucleic Acids Research
Квартиль SCImagoQ1
Квартиль WOSQ1
Impact factor14.9
ISSN03051048, 13624962
Genetics
Краткое описание
Abstract Several studies have described functional peptides encoded in RNA that are considered to be noncoding. Telomerase RNA together with telomerase reverse transcriptase and regulatory proteins make up the telomerase complex, the major component of the telomere length-maintaining machinery. In contrast to protein subunits, telomerase RNA is expressed constitutively in most somatic cells where telomerase reverse transcriptase is absent. We show here that the transcript of human telomerase RNA codes a 121 amino acid protein (hTERP). The existence of hTERP was shown by immunoblotting, immunofluorescence microscopy and mass spectroscopy. Gain-of-function and loss-of-function experiments showed that hTERP protects cells from drug-induced apoptosis and participates in the processing of autophagosome. We suggest that hTERP regulates crosstalk between autophagy and apoptosis and is involved in cellular adaptation under stress conditions.

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ГОСТ |
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Rubtsova M. et al. Protein encoded in human telomerase RNA is involved in cell protective pathways // Nucleic Acids Research. 2018. Vol. 46. No. 17. pp. 8966-8977.
ГОСТ со всеми авторами (до 50) Скопировать
Rubtsova M., Naraykina Y., Vasilkova D., Meerson M., Zvereva M., Prassolov V., Lazarev V., Manuvera V., Kovalchuk S. I., Anikanov N., Butenko I., Pobeguts O., Govorun V. M., Dontsova O. Protein encoded in human telomerase RNA is involved in cell protective pathways // Nucleic Acids Research. 2018. Vol. 46. No. 17. pp. 8966-8977.
RIS |
Цитировать
TY - JOUR
DO - 10.1093/nar/gky705
UR - https://doi.org/10.1093/nar/gky705
TI - Protein encoded in human telomerase RNA is involved in cell protective pathways
T2 - Nucleic Acids Research
AU - Naraykina, Yulia
AU - Vasilkova, Daria
AU - Meerson, Mark
AU - Zvereva, Maria
AU - Prassolov, Vladimir
AU - Lazarev, Vasily
AU - Manuvera, Valentin
AU - Anikanov, Nickolay
AU - Pobeguts, Olga
AU - Dontsova, Olga
AU - Rubtsova, Maria
AU - Kovalchuk, Sergey I.
AU - Butenko, Ivan
AU - Govorun, Vadim M.
PY - 2018
DA - 2018/08/08 00:00:00
PB - Oxford University Press
SP - 8966-8977
IS - 17
VL - 46
PMID - 30102362
SN - 0305-1048
SN - 1362-4962
ER -
BibTex |
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@article{2018_Rubtsova
author = {Yulia Naraykina and Daria Vasilkova and Mark Meerson and Maria Zvereva and Vladimir Prassolov and Vasily Lazarev and Valentin Manuvera and Nickolay Anikanov and Olga Pobeguts and Olga Dontsova and Maria Rubtsova and Sergey I. Kovalchuk and Ivan Butenko and Vadim M. Govorun},
title = {Protein encoded in human telomerase RNA is involved in cell protective pathways},
journal = {Nucleic Acids Research},
year = {2018},
volume = {46},
publisher = {Oxford University Press},
month = {aug},
url = {https://doi.org/10.1093/nar/gky705},
number = {17},
pages = {8966--8977},
doi = {10.1093/nar/gky705}
}
MLA
Цитировать
Rubtsova, Maria, et al. “Protein encoded in human telomerase RNA is involved in cell protective pathways.” Nucleic Acids Research, vol. 46, no. 17, Aug. 2018, pp. 8966-8977. https://doi.org/10.1093/nar/gky705.