Open Access
Nucleic Acids Research, volume 46, issue 17, pages 8966-8977
Protein encoded in human telomerase RNA is involved in cell protective pathways
Rubtsova Maria
1, 2
,
Naraykina Yulia
1, 3
,
Vasilkova Daria
2
,
Meerson Mark
3
,
Zvereva Maria
2
,
Prassolov Vladimir
4
,
Lazarev Vasily
5
,
Manuvera Valentin
5
,
Anikanov Nickolay
5
,
Butenko Ivan
5
,
Pobeguts Olga
5
,
Govorun Vadim M.
5
,
Dontsova Olga
1, 2, 6
Publication type: Journal Article
Publication date: 2018-08-08
Journal:
Nucleic Acids Research
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 14.9
ISSN: 03051048, 13624962
PubMed ID:
30102362
Genetics
Abstract
Abstract Several studies have described functional peptides encoded in RNA that are considered to be noncoding. Telomerase RNA together with telomerase reverse transcriptase and regulatory proteins make up the telomerase complex, the major component of the telomere length-maintaining machinery. In contrast to protein subunits, telomerase RNA is expressed constitutively in most somatic cells where telomerase reverse transcriptase is absent. We show here that the transcript of human telomerase RNA codes a 121 amino acid protein (hTERP). The existence of hTERP was shown by immunoblotting, immunofluorescence microscopy and mass spectroscopy. Gain-of-function and loss-of-function experiments showed that hTERP protects cells from drug-induced apoptosis and participates in the processing of autophagosome. We suggest that hTERP regulates crosstalk between autophagy and apoptosis and is involved in cellular adaptation under stress conditions.
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Citations by publishers
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2
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12
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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GOST
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Rubtsova M. et al. Protein encoded in human telomerase RNA is involved in cell protective pathways // Nucleic Acids Research. 2018. Vol. 46. No. 17. pp. 8966-8977.
GOST all authors (up to 50)
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Rubtsova M., Naraykina Y., Vasilkova D., Meerson M., Zvereva M., Prassolov V., Lazarev V., Manuvera V., Kovalchuk S. I., Anikanov N., Butenko I., Pobeguts O., Govorun V. M., Dontsova O. Protein encoded in human telomerase RNA is involved in cell protective pathways // Nucleic Acids Research. 2018. Vol. 46. No. 17. pp. 8966-8977.
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RIS
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TY - JOUR
DO - 10.1093/nar/gky705
UR - https://doi.org/10.1093%2Fnar%2Fgky705
TI - Protein encoded in human telomerase RNA is involved in cell protective pathways
T2 - Nucleic Acids Research
AU - Naraykina, Yulia
AU - Vasilkova, Daria
AU - Meerson, Mark
AU - Zvereva, Maria
AU - Prassolov, Vladimir
AU - Lazarev, Vasily
AU - Manuvera, Valentin
AU - Anikanov, Nickolay
AU - Pobeguts, Olga
AU - Dontsova, Olga
AU - Rubtsova, Maria
AU - Kovalchuk, Sergey I.
AU - Butenko, Ivan
AU - Govorun, Vadim M.
PY - 2018
DA - 2018/08/08 00:00:00
PB - Oxford University Press
SP - 8966-8977
IS - 17
VL - 46
PMID - 30102362
SN - 0305-1048
SN - 1362-4962
ER -
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@article{2018_Rubtsova,
author = {Yulia Naraykina and Daria Vasilkova and Mark Meerson and Maria Zvereva and Vladimir Prassolov and Vasily Lazarev and Valentin Manuvera and Nickolay Anikanov and Olga Pobeguts and Olga Dontsova and Maria Rubtsova and Sergey I. Kovalchuk and Ivan Butenko and Vadim M. Govorun},
title = {Protein encoded in human telomerase RNA is involved in cell protective pathways},
journal = {Nucleic Acids Research},
year = {2018},
volume = {46},
publisher = {Oxford University Press},
month = {aug},
url = {https://doi.org/10.1093%2Fnar%2Fgky705},
number = {17},
pages = {8966--8977},
doi = {10.1093/nar/gky705}
}
Cite this
MLA
Copy
Rubtsova, Maria, et al. “Protein encoded in human telomerase RNA is involved in cell protective pathways.” Nucleic Acids Research, vol. 46, no. 17, Aug. 2018, pp. 8966-8977. https://doi.org/10.1093%2Fnar%2Fgky705.