Open Access
Hypoosmotic stress induces R loop formation in nucleoli and ATR/ATM-dependent silencing of nucleolar transcription
Artem K. Velichko
1, 2
,
Nadezhda V. Petrova
1
,
Artem V. Luzhin
1
,
Olga S Strelkova
3
,
I. Kireev
3, 4
,
Nataliya V Petrova
5
,
С. В. Разин
5, 6, 7
,
Omar L. Kantidze
1, 7
Publication type: Journal Article
Publication date: 2019-05-22
scimago Q1
wos Q1
SJR: 7.776
CiteScore: 31.7
Impact factor: 13.1
ISSN: 03051048, 13624962
PubMed ID:
31114877
Genetics
Abstract
The contribution of nucleoli to the cellular stress response has been discussed for over a decade. Stress-induced inhibition of RNA polymerase I-dependent transcription is hypothesized as a possible effector program in such a response. In this study, we report a new mechanism by which ribosomal DNA transcription can be inhibited in response to cellular stress. Specifically, we demonstrate that mild hypoosmotic stress induces stabilization of R loops in ribosomal genes and thus provokes the nucleoli-specific DNA damage response, which is governed by the ATM- and Rad3-related (ATR) kinase. Activation of ATR in nucleoli strongly depends on Treacle, which is needed for efficient recruitment/retention of TopBP1 in nucleoli. Subsequent ATR-mediated activation of ATM results in repression of nucleolar transcription.
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Metrics
37
Total citations:
37
Citations from 2024:
7
(18%)
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GOST
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Velichko A. K. et al. Hypoosmotic stress induces R loop formation in nucleoli and ATR/ATM-dependent silencing of nucleolar transcription // Nucleic Acids Research. 2019. Vol. 47. No. 13. pp. 6811-6825.
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Velichko A. K., Petrova N. V., Luzhin A. V., Strelkova O. S., Ovsyannikova N., Kireev I., Petrova N. V., Разин С. В., Kantidze O. L. Hypoosmotic stress induces R loop formation in nucleoli and ATR/ATM-dependent silencing of nucleolar transcription // Nucleic Acids Research. 2019. Vol. 47. No. 13. pp. 6811-6825.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1093/nar/gkz436
UR - https://doi.org/10.1093/nar/gkz436
TI - Hypoosmotic stress induces R loop formation in nucleoli and ATR/ATM-dependent silencing of nucleolar transcription
T2 - Nucleic Acids Research
AU - Velichko, Artem K.
AU - Petrova, Nadezhda V.
AU - Luzhin, Artem V.
AU - Strelkova, Olga S
AU - Ovsyannikova, Natalia
AU - Kireev, I.
AU - Petrova, Nataliya V
AU - Разин, С. В.
AU - Kantidze, Omar L.
PY - 2019
DA - 2019/05/22
PB - Oxford University Press
SP - 6811-6825
IS - 13
VL - 47
PMID - 31114877
SN - 0305-1048
SN - 1362-4962
ER -
Cite this
BibTex (up to 50 authors)
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@article{2019_Velichko,
author = {Artem K. Velichko and Nadezhda V. Petrova and Artem V. Luzhin and Olga S Strelkova and Natalia Ovsyannikova and I. Kireev and Nataliya V Petrova and С. В. Разин and Omar L. Kantidze},
title = {Hypoosmotic stress induces R loop formation in nucleoli and ATR/ATM-dependent silencing of nucleolar transcription},
journal = {Nucleic Acids Research},
year = {2019},
volume = {47},
publisher = {Oxford University Press},
month = {may},
url = {https://doi.org/10.1093/nar/gkz436},
number = {13},
pages = {6811--6825},
doi = {10.1093/nar/gkz436}
}
Cite this
MLA
Copy
Velichko, Artem K., et al. “Hypoosmotic stress induces R loop formation in nucleoli and ATR/ATM-dependent silencing of nucleolar transcription.” Nucleic Acids Research, vol. 47, no. 13, May. 2019, pp. 6811-6825. https://doi.org/10.1093/nar/gkz436.