Population Pharmacokinetics of Phenobarbital in Infants With Neonatal Encephalopathy Treated With Therapeutic Hypothermia*
4
Pediatrics - Neonatology/Perinatology
5
Pediatrics and Communicable Diseases
Publication type: Journal Article
Publication date: 2012-12-19
scimago Q1
wos Q1
SJR: 1.028
CiteScore: 7.2
Impact factor: 4.5
ISSN: 15297535, 19473893
PubMed ID:
23254984
Critical Care and Intensive Care Medicine
Pediatrics, Perinatology and Child Health
Abstract
Phenobarbital is the first-line treatment for neonatal seizures. Many neonates with hypoxic ischemic encephalopathy are treated with therapeutic hypothermia, and about 40% have clinical seizures. Little is known about the pharmacokinetics of phenobarbital in infants with hypoxic ischemic encephalopathy who undergo therapeutic hypothermia. The objective of this study was to determine the effect of therapeutic hypothermia on phenobarbital pharmacokinetics, taking into account maturational changes.Level 3 neonatal ICU.Infants with hypoxic ischemic encephalopathy and suspected seizures, all treated with phenobarbital. Some of these infants also received treatment with therapeutic hypothermia.None.A retrospective cohort study of 39 infants with hypoxic ischemic encephalopathy treated with phenobarbital (20 were treated with therapeutic hypothermia and 19 were not).Data on phenobarbital plasma concentrations were collected in 39 subjects with hypoxic ischemic encephalopathy with or without therapeutic hypothermia. Using nonlinear mixed-effects modeling, population pharmacokinetics of phenobarbital were developed with a total of 164 plasma concentrations. A one-compartment model best described the pharmacokinetics. The clearance of phenobarbital was linearly related to body weight and matured with increasing age with a maturation half-life of 22.1 days. Therapeutic hypothermia did not influence the pharmacokinetic parameters of phenobarbital.Therapeutic hypothermia does not influence the clearance of phenobarbital after accounting for weight and age. Standard phenobarbital dosing is appropriate for the initial treatment of seizures in neonates with hypoxic ischemic encephalopathy treated with therapeutic hypothermia.
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Shellhaas R. A. et al. Population Pharmacokinetics of Phenobarbital in Infants With Neonatal Encephalopathy Treated With Therapeutic Hypothermia* // Pediatric Critical Care Medicine. 2012. Vol. 14. No. 2. pp. 194-202.
GOST all authors (up to 50)
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Shellhaas R. A., Ng C. M., Dillon C. H., Barks J., Bhatt-Mehta V. Population Pharmacokinetics of Phenobarbital in Infants With Neonatal Encephalopathy Treated With Therapeutic Hypothermia* // Pediatric Critical Care Medicine. 2012. Vol. 14. No. 2. pp. 194-202.
Cite this
RIS
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TY - JOUR
DO - 10.1097/PCC.0b013e31825bbbc2
UR - https://doi.org/10.1097/PCC.0b013e31825bbbc2
TI - Population Pharmacokinetics of Phenobarbital in Infants With Neonatal Encephalopathy Treated With Therapeutic Hypothermia*
T2 - Pediatric Critical Care Medicine
AU - Shellhaas, Renée A.
AU - Ng, Chee M.
AU - Dillon, Christina H.
AU - Barks, J.
AU - Bhatt-Mehta, V.
PY - 2012
DA - 2012/12/19
PB - Ovid Technologies (Wolters Kluwer Health)
SP - 194-202
IS - 2
VL - 14
PMID - 23254984
SN - 1529-7535
SN - 1947-3893
ER -
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BibTex (up to 50 authors)
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@article{2012_Shellhaas,
author = {Renée A. Shellhaas and Chee M. Ng and Christina H. Dillon and J. Barks and V. Bhatt-Mehta},
title = {Population Pharmacokinetics of Phenobarbital in Infants With Neonatal Encephalopathy Treated With Therapeutic Hypothermia*},
journal = {Pediatric Critical Care Medicine},
year = {2012},
volume = {14},
publisher = {Ovid Technologies (Wolters Kluwer Health)},
month = {dec},
url = {https://doi.org/10.1097/PCC.0b013e31825bbbc2},
number = {2},
pages = {194--202},
doi = {10.1097/PCC.0b013e31825bbbc2}
}
Cite this
MLA
Copy
Shellhaas, Renée A., et al. “Population Pharmacokinetics of Phenobarbital in Infants With Neonatal Encephalopathy Treated With Therapeutic Hypothermia*.” Pediatric Critical Care Medicine, vol. 14, no. 2, Dec. 2012, pp. 194-202. https://doi.org/10.1097/PCC.0b013e31825bbbc2.