Associations of the EAT-Lancet reference diet with metabolic dysfunction-associated steatotic liver disease and its severity: a multi-cohort study

Shunming Zhang 1
, 
Yan Yan 2
, 
Xu-Fen Zeng 3
, 
Yeqing Gu 4
, 
Hongmei Wu 5, 6
, 
Qing Zhang 7
, 
Liu Li 7
, 
Zhenyu Huo 8
, 
Xiaoqin Luo 1
, 
Rui Zhang 3
, 
Emily Sonestedt 9
, 
Yan Borné 9
, 
Lu Qi 10, 11
, 
Tao Huang 12
, 
Ming-Hua Zheng 13, 14
, 
Yu-ming Chen 2
, 
Yu Zhu 2
, 
Kaijun Niu 5, 6, 7
, 
Le Ma 1
, 
马乐 Le Ma 1
1
 
2
 
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14
 
Key Laboratory of Diagnosis and Treatment for The Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, Zhejiang, China | 
Publication type: Journal Article
Publication date: 2024-08-02
Ovid Technologies (Wolters Kluwer Health)
scimago Q1
wos Q1
SJR: 5.557
CiteScore: 29.7
Impact factor: 15.8
ISSN: 02709139, 15273350
Abstract
Background & Aims:

The EAT-Lancet Commission devised a globally sustainable dietary pattern to jointly promote human health and sustainability. However, the extent to which this diet supports metabolic dysfunction-associated steatotic liver disease (MASLD) has not yet been assessed. This study aimed to investigate the association between the EAT-Lancet diet and risk of MASLD and its severity.

Approach & Results:

This prospective multi-cohort study included 15,263 adults from the Tianjin Chronic Low-grade Systemic Inflammation and Health (TCLSIH) cohort, 1,137 adults from the Guangzhou Nutrition and Health Study (GNHS) cohort, and 175,078 adults from the UK Biobank. Additionally, 228 Chinese adults from the Prospective Epidemic Research Specifically of Non-alcoholic Steatohepatitis (PERSONS) with biopsy-proven MASLD were included. An EAT-Lancet diet index was created to reflect adherence to the EAT-Lancet reference diet. The TCLSIH cohort recorded 3,010 MASLD cases during 53,575 person-years of follow-up, the GNHS cohort documented 624 MASLD cases during 6,454 person-years of follow-up, and the UK Biobank 1,350 developed MASLD cases during 1,745,432 person-years of follow-up. In multivariable models, participants in the highest tertiles of the EAT-Lancet diet index had a lower risk of MASLD compared with those in the lowest tertiles (TCLSIH: HR=0.87, 95% CI: 0.78, 0.96; GNHS: HR=0.79, 95% CI: 0.64, 0.98; UK Biobank: HR=0.73, 95% CI: 0.63, 0.85). Moreover, liver controlled attenuation parameter decreased with increasing the diet index in individuals with biopsy-proven MASLD (β=−5.895; 95% CI: −10.014, −1.775).

Conclusions:

Adherence to the EAT-Lancet reference diet was inversely associated with risk of MASLD as well as its severity.

Found 
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GOST |
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GOST Copy
Zhang S. et al. Associations of the EAT-Lancet reference diet with metabolic dysfunction-associated steatotic liver disease and its severity: a multi-cohort study // Hepatology. 2024.
GOST all authors (up to 50) Copy
Zhang S., Yan Y., Zeng X., Gu Y., Wu H., Zhang Q., Liu Li, Huo Z., Luo X., Zhang R., Sonestedt E., Borné Y., Qi L., Huang T., Zheng M., Chen Y., Zhu Yu., Niu K., Ma L., Le Ma 马. Associations of the EAT-Lancet reference diet with metabolic dysfunction-associated steatotic liver disease and its severity: a multi-cohort study // Hepatology. 2024.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1097/hep.0000000000001039
UR - https://journals.lww.com/10.1097/HEP.0000000000001039
TI - Associations of the EAT-Lancet reference diet with metabolic dysfunction-associated steatotic liver disease and its severity: a multi-cohort study
T2 - Hepatology
AU - Zhang, Shunming
AU - Yan, Yan
AU - Zeng, Xu-Fen
AU - Gu, Yeqing
AU - Wu, Hongmei
AU - Zhang, Qing
AU - Liu Li
AU - Huo, Zhenyu
AU - Luo, Xiaoqin
AU - Zhang, Rui
AU - Sonestedt, Emily
AU - Borné, Yan
AU - Qi, Lu
AU - Huang, Tao
AU - Zheng, Ming-Hua
AU - Chen, Yu-ming
AU - Zhu, Yu
AU - Niu, Kaijun
AU - Ma, Le
AU - Le Ma, 马乐
PY - 2024
DA - 2024/08/02
PB - Ovid Technologies (Wolters Kluwer Health)
PMID - 39094016
SN - 0270-9139
SN - 1527-3350
ER -
BibTex
Cite this
BibTex (up to 50 authors) Copy
@article{2024_Zhang,
author = {Shunming Zhang and Yan Yan and Xu-Fen Zeng and Yeqing Gu and Hongmei Wu and Qing Zhang and Liu Li and Zhenyu Huo and Xiaoqin Luo and Rui Zhang and Emily Sonestedt and Yan Borné and Lu Qi and Tao Huang and Ming-Hua Zheng and Yu-ming Chen and Yu Zhu and Kaijun Niu and Le Ma and 马乐 Le Ma},
title = {Associations of the EAT-Lancet reference diet with metabolic dysfunction-associated steatotic liver disease and its severity: a multi-cohort study},
journal = {Hepatology},
year = {2024},
publisher = {Ovid Technologies (Wolters Kluwer Health)},
month = {aug},
url = {https://journals.lww.com/10.1097/HEP.0000000000001039},
doi = {10.1097/hep.0000000000001039}
}