Ovid Technologies (Wolters Kluwer Health)
European Journal of Gastroenterology and Hepatology
,  volume 36 ,  issue 1 ,  pages 89-96

Impact of continued alcohol use on liver-related outcomes of alcohol-associated cirrhosis: a retrospective study of 440 patients

Georgios N Kalambokis 1
, 
Nikolleta Chouliara 1
, 
Ilias Tsiakas 1
, 
Sempastien Filippas-Ntekuan 1
, 
Maria Christaki 1
, 
Grigorios Despotis 1
, 
Haralampos Milionis 1
1
 
Publication type: Journal Article
Publication date: 2024-01-01
Ovid Technologies (Wolters Kluwer Health)
scimago Q2
wos Q3
SJR: 0.731
CiteScore: 4.6
Impact factor: 1.8
ISSN: 0954691X, 14735687
Gastroenterology
Hepatology
Abstract
Background and aim

The prevalence of alcohol-associated cirrhosis is increasing. In this respect, we investigated the long-term impact of non-abstinence on the clinical course of alcohol-associated cirrhosis.

Methods

We retrospectively evaluated 440 patients with alcohol-associated cirrhosis (compensated cirrhosis: n = 190; decompensated cirrhosis: n = 250) diagnosed between January 2000 and July 2017 who consumed alcohol until diagnosis of cirrhosis. We assessed liver-related outcomes including first and further decompensating events (ascites, variceal bleeding, and hepatic encephalopathy), and death in relation to continued alcohol use.

Results

Overall, 53.6% of patients remained abstinent (compensated cirrhosis: 57.9%; decompensated cirrhosis: 50.4%). Non-abstinent versus abstinent patients with compensated cirrhosis and decompensated cirrhosis showed significantly higher 5-year probability of first decompensation (80.2% vs. 36.8%; P < 0.001) and further decompensation (87.9% vs. 20.6%; P < 0.001), respectively. Five-year survival was substantially lower among non-abstinent patients with compensated cirrhosis (45.9% vs. 90.7%; P < 0.001) and decompensated cirrhosis (22.9% vs. 73.8%; P < 0.001) compared to abstinent. Non-abstinent versus abstinent patients of the total cohort showed an exceedingly lower 5-year survival (32.2% vs. 82.4%; P < 0.001). Prolonged abstinence (≥2 years) was required to influence outcomes. Non-abstinence independently predicted mortality in the total cohort (hazard ratio [HR] 3.371; confidence interval [CI]: 2.388–4.882; P < 0.001) along with the Child-Pugh class (HR: 4.453; CI: 2.907–6.823; P < 0.001) and higher age (HR: 1.023; CI: 1.007–1.039; P = 0.005).

Conclusion

Liver-related outcomes are worse among non-abstinent patients with alcohol- associated cirrhosis prompting urgent interventions ensuring abstinence.

Found 
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GOST |
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GOST Copy
Kalambokis G. N. et al. Impact of continued alcohol use on liver-related outcomes of alcohol-associated cirrhosis: a retrospective study of 440 patients // European Journal of Gastroenterology and Hepatology. 2024. Vol. 36. No. 1. pp. 89-96.
GOST all authors (up to 50) Copy
Kalambokis G. N., Chouliara N., Tsiakas I., Filippas-Ntekuan S., Christaki M., Despotis G., Milionis H. Impact of continued alcohol use on liver-related outcomes of alcohol-associated cirrhosis: a retrospective study of 440 patients // European Journal of Gastroenterology and Hepatology. 2024. Vol. 36. No. 1. pp. 89-96.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1097/meg.0000000000002648
UR - https://doi.org/10.1097/meg.0000000000002648
TI - Impact of continued alcohol use on liver-related outcomes of alcohol-associated cirrhosis: a retrospective study of 440 patients
T2 - European Journal of Gastroenterology and Hepatology
AU - Kalambokis, Georgios N
AU - Chouliara, Nikolleta
AU - Tsiakas, Ilias
AU - Filippas-Ntekuan, Sempastien
AU - Christaki, Maria
AU - Despotis, Grigorios
AU - Milionis, Haralampos
PY - 2024
DA - 2024/01/01
PB - Ovid Technologies (Wolters Kluwer Health)
SP - 89-96
IS - 1
VL - 36
PMID - 37823451
SN - 0954-691X
SN - 1473-5687
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2024_Kalambokis,
author = {Georgios N Kalambokis and Nikolleta Chouliara and Ilias Tsiakas and Sempastien Filippas-Ntekuan and Maria Christaki and Grigorios Despotis and Haralampos Milionis},
title = {Impact of continued alcohol use on liver-related outcomes of alcohol-associated cirrhosis: a retrospective study of 440 patients},
journal = {European Journal of Gastroenterology and Hepatology},
year = {2024},
volume = {36},
publisher = {Ovid Technologies (Wolters Kluwer Health)},
month = {jan},
url = {https://doi.org/10.1097/meg.0000000000002648},
number = {1},
pages = {89--96},
doi = {10.1097/meg.0000000000002648}
}
MLA
Cite this
MLA Copy
Kalambokis, Georgios N., et al. “Impact of continued alcohol use on liver-related outcomes of alcohol-associated cirrhosis: a retrospective study of 440 patients.” European Journal of Gastroenterology and Hepatology, vol. 36, no. 1, Jan. 2024, pp. 89-96. https://doi.org/10.1097/meg.0000000000002648.