Paracetamol – An old drug with new mechanisms of action
Publication type: Journal Article
Publication date: 2020-09-04
scimago Q2
wos Q2
SJR: 0.625
CiteScore: 5.5
Impact factor: 2.5
ISSN: 03051870, 14401681
PubMed ID:
32767405
Pharmacology
Physiology
Physiology (medical)
Abstract
Paracetamol (acetaminophen) is the most commonly used over-the-counter (OTC) drug in the world. Despite its popularity and use for many years, the safety of its application and its mechanism of action are still unclear. Currently, it is believed that paracetamol is a multidirectional drug and at least several metabolic pathways are involved in its analgesic and antipyretic action. The mechanism of paracetamol action consists in inhibition of cyclooxygenases (COX-1, COX-2, and COX-3) and involvement in the endocannabinoid system and serotonergic pathways. Additionally, paracetamol influences transient receptor potential (TRP) channels and voltage-gated Kv7 potassium channels and inhibits T-type Cav3.2 calcium channels. It also exerts an impact on L-arginine in the nitric oxide (NO) synthesis pathway. However, not all of these effects have been clearly confirmed. Therefore, the aim of our paper was to summarize the current state of knowledge of the mechanism of paracetamol action with special attention to its safety concerns.
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Citations from 2024:
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GOST
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Przybyła G. W., Szychowski K. A., Gmiński J. Paracetamol – An old drug with new mechanisms of action // Clinical and Experimental Pharmacology and Physiology. 2020. Vol. 48. No. 1. pp. 3-19.
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Przybyła G. W., Szychowski K. A., Gmiński J. Paracetamol – An old drug with new mechanisms of action // Clinical and Experimental Pharmacology and Physiology. 2020. Vol. 48. No. 1. pp. 3-19.
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RIS
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TY - JOUR
DO - 10.1111/1440-1681.13392
UR - https://doi.org/10.1111/1440-1681.13392
TI - Paracetamol – An old drug with new mechanisms of action
T2 - Clinical and Experimental Pharmacology and Physiology
AU - Przybyła, Grzegorz W
AU - Szychowski, Konrad A
AU - Gmiński, J.
PY - 2020
DA - 2020/09/04
PB - Wiley
SP - 3-19
IS - 1
VL - 48
PMID - 32767405
SN - 0305-1870
SN - 1440-1681
ER -
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BibTex (up to 50 authors)
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@article{2020_Przybyła,
author = {Grzegorz W Przybyła and Konrad A Szychowski and J. Gmiński},
title = {Paracetamol – An old drug with new mechanisms of action},
journal = {Clinical and Experimental Pharmacology and Physiology},
year = {2020},
volume = {48},
publisher = {Wiley},
month = {sep},
url = {https://doi.org/10.1111/1440-1681.13392},
number = {1},
pages = {3--19},
doi = {10.1111/1440-1681.13392}
}
Cite this
MLA
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Przybyła, Grzegorz W., et al. “Paracetamol – An old drug with new mechanisms of action.” Clinical and Experimental Pharmacology and Physiology, vol. 48, no. 1, Sep. 2020, pp. 3-19. https://doi.org/10.1111/1440-1681.13392.