Basic and Clinical Pharmacology and Toxicology, volume 130, issue 4, pages 439-456

A narrative review of molecular mechanism and therapeutic effect of cannabidiol (CBD)

Jiangling Peng ¹

Mingjie Fan ¹

Chelsea An ¹

Feng Ni ²

Wendong Huang ¹

Jiankang Luo ³

Show full list: 6 authors

Hide authors affiliations Show authors affiliations: 3 affiliations

Department of Diabetes Complications and Metabolism, Beckman Research Institute City of Hope National Medical Center Duarte California USA |

Institute of Drug Discovery Technology Ningbo University Ningbo China |

Chemtech Zone Inc Alhambra California USA |

Publication type: Journal Article

Publication date: 2022-02-06

Wiley

Journal: Basic and Clinical Pharmacology and Toxicology

scimago Q2

SJR: 0.744

CiteScore: 5.6

Impact factor: 2.7

ISSN: 17427835, 17427843

DOI: 10.1111/bcpt.13710

Copy DOI

General Medicine

Pharmacology

Toxicology

Abstract

Cannabidiol (CBD) is an abundant non-psychoactive phytocannabinoid in cannabis extracts which has high affinity on a series of receptors, including Type 1 cannabinoid receptor (CB1), Type 2 cannabinoid receptor (CB2), GPR55, transient receptor potential vanilloid (TRPV) and peroxisome proliferator-activated receptor gamma (PPARγ). By modulating the activities of these receptors, CBD exhibits multiple therapeutic effects, including neuroprotective, antiepileptic, anxiolytic, antipsychotic, anti-inflammatory, analgesic and anticancer properties. CBD could also be applied to treat or prevent COVID-19 and its complications. Here, we provide a narrative review of CBD's applications in human diseases: from mechanism of action to clinical trials.

Found

Top-30

Journals

	2 4 6 8 10
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 10, 6.45% International Journal of Molecular Sciences 10 publications, 6.45%
Pharmaceuticals	Pharmaceuticals, 6, 3.87% Pharmaceuticals 6 publications, 3.87%
Molecules	Molecules, 5, 3.23% Molecules 5 publications, 3.23%
Frontiers in Pharmacology	Frontiers in Pharmacology, 5, 3.23% Frontiers in Pharmacology 5 publications, 3.23%
Biomolecules	Biomolecules, 5, 3.23% Biomolecules 5 publications, 3.23%
Pharmaceutics	Pharmaceutics, 4, 2.58% Pharmaceutics 4 publications, 2.58%
Cannabis and Cannabinoid Research	Cannabis and Cannabinoid Research, 3, 1.94% Cannabis and Cannabinoid Research 3 publications, 1.94%
Progress in Neuro-Psychopharmacology and Biological Psychiatry	Progress in Neuro-Psychopharmacology and Biological Psychiatry, 3, 1.94% Progress in Neuro-Psychopharmacology and Biological Psychiatry 3 publications, 1.94%
Journal of Psychopharmacology	Journal of Psychopharmacology, 2, 1.29% Journal of Psychopharmacology 2 publications, 1.29%
Life	Life, 2, 1.29% Life 2 publications, 1.29%
Frontiers in Veterinary Science	Frontiers in Veterinary Science, 2, 1.29% Frontiers in Veterinary Science 2 publications, 1.29%
Genes	Genes, 2, 1.29% Genes 2 publications, 1.29%
Biomedicines	Biomedicines, 2, 1.29% Biomedicines 2 publications, 1.29%
Neuroscience and Biobehavioral Reviews	Neuroscience and Biobehavioral Reviews, 2, 1.29% Neuroscience and Biobehavioral Reviews 2 publications, 1.29%
Plants	Plants, 2, 1.29% Plants 2 publications, 1.29%
Pharmacological Reports	Pharmacological Reports, 2, 1.29% Pharmacological Reports 2 publications, 1.29%
European Journal of Medicinal Chemistry	European Journal of Medicinal Chemistry, 2, 1.29% European Journal of Medicinal Chemistry 2 publications, 1.29%
Journal of Drug Delivery Science and Technology	Journal of Drug Delivery Science and Technology, 2, 1.29% Journal of Drug Delivery Science and Technology 2 publications, 1.29%
Toxicology and Applied Pharmacology	Toxicology and Applied Pharmacology, 2, 1.29% Toxicology and Applied Pharmacology 2 publications, 1.29%
Food and Chemical Toxicology	Food and Chemical Toxicology, 2, 1.29% Food and Chemical Toxicology 2 publications, 1.29%
Medical Cannabis and Cannabinoids	Medical Cannabis and Cannabinoids, 2, 1.29% Medical Cannabis and Cannabinoids 2 publications, 1.29%
Molecular Pharmaceutics	Molecular Pharmaceutics, 2, 1.29% Molecular Pharmaceutics 2 publications, 1.29%
JOR Spine	JOR Spine, 1, 0.65% JOR Spine 1 publication, 0.65%
Current Topics in Medicinal Chemistry	Current Topics in Medicinal Chemistry, 1, 0.65% Current Topics in Medicinal Chemistry 1 publication, 0.65%
Biological and Pharmaceutical Bulletin	Biological and Pharmaceutical Bulletin, 1, 0.65% Biological and Pharmaceutical Bulletin 1 publication, 0.65%
Pharmaceutical Research	Pharmaceutical Research, 1, 0.65% Pharmaceutical Research 1 publication, 0.65%
Cellular and Molecular Life Sciences	Cellular and Molecular Life Sciences, 1, 0.65% Cellular and Molecular Life Sciences 1 publication, 0.65%
Translational Psychiatry	Translational Psychiatry, 1, 0.65% Translational Psychiatry 1 publication, 0.65%
Food Research International	Food Research International, 1, 0.65% Food Research International 1 publication, 0.65%
	2 4 6 8 10

Publishers

	5 10 15 20 25 30 35 40 45
MDPI	MDPI, 44, 28.39% MDPI 44 publications, 28.39%
Elsevier	Elsevier, 43, 27.74% Elsevier 43 publications, 27.74%
Springer Nature	Springer Nature, 17, 10.97% Springer Nature 17 publications, 10.97%
Frontiers Media S.A.	Frontiers Media S.A., 7, 4.52% Frontiers Media S.A. 7 publications, 4.52%
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 6, 3.87% Cold Spring Harbor Laboratory 6 publications, 3.87%
Wiley	Wiley, 5, 3.23% Wiley 5 publications, 3.23%
American Chemical Society (ACS)	American Chemical Society (ACS), 4, 2.58% American Chemical Society (ACS) 4 publications, 2.58%
Mary Ann Liebert	Mary Ann Liebert, 3, 1.94% Mary Ann Liebert 3 publications, 1.94%
Taylor & Francis	Taylor & Francis, 3, 1.94% Taylor & Francis 3 publications, 1.94%
SAGE	SAGE, 2, 1.29% SAGE 2 publications, 1.29%
Ovid Technologies (Wolters Kluwer Health)	Ovid Technologies (Wolters Kluwer Health), 2, 1.29% Ovid Technologies (Wolters Kluwer Health) 2 publications, 1.29%
Oxford University Press	Oxford University Press, 2, 1.29% Oxford University Press 2 publications, 1.29%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 2, 1.29% Royal Society of Chemistry (RSC) 2 publications, 1.29%
S. Karger AG	S. Karger AG, 2, 1.29% S. Karger AG 2 publications, 1.29%
Bentham Science Publishers Ltd.	Bentham Science Publishers Ltd., 1, 0.65% Bentham Science Publishers Ltd. 1 publication, 0.65%
Pharmaceutical Society of Japan	Pharmaceutical Society of Japan, 1, 0.65% Pharmaceutical Society of Japan 1 publication, 0.65%
LLC Science and Innovations	LLC Science and Innovations, 1, 0.65% LLC Science and Innovations 1 publication, 0.65%
American Society for Biochemistry and Molecular Biology	American Society for Biochemistry and Molecular Biology, 1, 0.65% American Society for Biochemistry and Molecular Biology 1 publication, 0.65%
American Dairy Science Association	American Dairy Science Association, 1, 0.65% American Dairy Science Association 1 publication, 0.65%
Hindawi Limited	Hindawi Limited, 1, 0.65% Hindawi Limited 1 publication, 0.65%
Research Square Platform LLC	Research Square Platform LLC, 1, 0.65% Research Square Platform LLC 1 publication, 0.65%
The American Academy of Sleep Medicine	The American Academy of Sleep Medicine, 1, 0.65% The American Academy of Sleep Medicine 1 publication, 0.65%
Vilnius University Press	Vilnius University Press, 1, 0.65% Vilnius University Press 1 publication, 0.65%
	5 10 15 20 25 30 35 40 45

We do not take into account publications without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
Statistics recalculated weekly.

Are you a researcher?

Create a profile to get free access to personal recommendations for colleagues and new articles.

Metrics

56 Field Citation Ratio

19 Relative Citation Ratio

Cite this

GOST |

Cite this

GOST Copy

Peng J. et al. A narrative review of molecular mechanism and therapeutic effect of cannabidiol (CBD) // Basic and Clinical Pharmacology and Toxicology. 2022. Vol. 130. No. 4. pp. 439-456.

GOST all authors (up to 50) Copy

Peng J., Fan M., An C., Ni F., Huang W., Luo J. A narrative review of molecular mechanism and therapeutic effect of cannabidiol (CBD) // Basic and Clinical Pharmacology and Toxicology. 2022. Vol. 130. No. 4. pp. 439-456.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1111/bcpt.13710

UR - https://doi.org/10.1111/bcpt.13710

TI - A narrative review of molecular mechanism and therapeutic effect of cannabidiol (CBD)

T2 - Basic and Clinical Pharmacology and Toxicology

AU - Peng, Jiangling

AU - Fan, Mingjie

AU - An, Chelsea

AU - Ni, Feng

AU - Huang, Wendong

AU - Luo, Jiankang

PY - 2022

DA - 2022/02/06

PB - Wiley

SP - 439-456

IS - 4

VL - 130

SN - 1742-7835

SN - 1742-7843

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2022_Peng,

author = {Jiangling Peng and Mingjie Fan and Chelsea An and Feng Ni and Wendong Huang and Jiankang Luo},

title = {A narrative review of molecular mechanism and therapeutic effect of cannabidiol (CBD)},

journal = {Basic and Clinical Pharmacology and Toxicology},

year = {2022},

volume = {130},

publisher = {Wiley},

month = {feb},

url = {https://doi.org/10.1111/bcpt.13710},

number = {4},

pages = {439--456},

doi = {10.1111/bcpt.13710}

}

MLA

Cite this

MLA Copy

Peng, Jiangling, et al. “A narrative review of molecular mechanism and therapeutic effect of cannabidiol (CBD).” Basic and Clinical Pharmacology and Toxicology, vol. 130, no. 4, Feb. 2022, pp. 439-456. https://doi.org/10.1111/bcpt.13710.

Found error?

Message

Support chat

Publisher

Wiley

Journal

Basic and Clinical Pharmacology and Toxicology

scimago Q2

SJR

0.744

CiteScore

5.6

Impact factor

2.7

ISSN

17427835 (Print)

17427843 (Electronic)