Journal of Neuroendocrinology, volume 32, issue 4
Audiogenic kindling activates expression of vasopressin in the hypothalamus of Krushinsky‐Molodkina rats genetically prone to reflex epilepsy
Publication type: Journal Article
Publication date: 2020-04-01
Journal:
Journal of Neuroendocrinology
Quartile SCImago
Q2
Quartile WOS
Q3
Impact factor: 3.2
ISSN: 09538194, 13652826
Endocrinology
Cellular and Molecular Neuroscience
Endocrinology, Diabetes and Metabolism
Endocrine and Autonomic Systems
Abstract
The present study analysed the effects of audiogenic kindling on the functional state of the vasopressinergic system of Krushinsky-Molodkina (KM) rats. KM rats represent a genetic model of audiogenic reflex epilepsy. Multiple audiogenic seizures in KM rats lead to the involvement of the limbic structures and neocortex in the epileptic network. The phenomenon of epileptic activity that overspreads from the brain stem to the forebrain is called audiogenic kindling and represents a model of limbic epilepsy. In the present study, audiogenic kindling was induced by 25 repetitive audiogenic seizures (AGS) with 1 AGS per day. A proportion of KM rats did not express AGS to sound stimuli, and these rats were characterised as the AGS-resistant group. The data demonstrated that audiogenic kindling did not change activity of extracellular signal-regulated kinase 1/2 or cAMP response element-binding protein, although it led to an increase in vasopressin (VP) expression in the supraoptic nucleus (SON) and in the magnocellular division of the paraventricular nucleus (PVN). Additionally, we observed a decrease in GABAergic innervation of the hypothalamic neuroendocrine neurones after audiogenic kindling, whereas glutamatergic innervation of the SON and PVN was not altered. By contrast, analysis of AGS-resistant KM rats did not reveal any changes in the activity of the VP-ergic system, confirming that the activation of VP expression was caused by repetitive AGS expression, rather than by repetitive acoustic stress. Thus, we suggest that overspread of epileptiform activity in the brain is the main factor that affects VP expression in the hypothalamic magnocellular neurones.
Citations by journals
|
1
2
|
|
|
Journal of Neuroendocrinology
|
Journal of Neuroendocrinology
2 publications, 50%
|
|
Biomedicines
|
Biomedicines
1 publication, 25%
|
|
Peptides
|
Peptides
1 publication, 25%
|
|
1
2
|
Citations by publishers
|
1
2
|
|
|
Wiley
|
Wiley
2 publications, 50%
|
|
Multidisciplinary Digital Publishing Institute (MDPI)
|
Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 25%
|
|
Elsevier
|
Elsevier
1 publication, 25%
|
|
1
2
|
- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2020,2021,2022,2023,2024],"ids":[0,0,0,0,0],"codes":[0,0,0,0,0],"imageUrls":["","","","",""],"datasets":[{"label":"Citations number","data":[1,1,0,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["25","25",0,"25","25"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Journal of Neuroendocrinology","Biomedicines","Peptides"],"ids":[16929,24421,13411],"codes":[0,0,0],"imageUrls":["\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp"],"datasets":[{"label":"","data":[2,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6"],"percentage":[50,25,25],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Wiley","Multidisciplinary Digital Publishing Institute (MDPI)","Elsevier"],"ids":[11,202,17],"codes":[0,0,0],"imageUrls":["\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp"],"datasets":[{"label":"","data":[2,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6"],"percentage":[50,25,25],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}
Metrics
Cite this
GOST |
RIS |
BibTex
Cite this
GOST
Copy
Harbachova E. L. et al. Audiogenic kindling activates expression of vasopressin in the hypothalamus of Krushinsky‐Molodkina rats genetically prone to reflex epilepsy // Journal of Neuroendocrinology. 2020. Vol. 32. No. 4.
GOST all authors (up to 50)
Copy
Harbachova E. L., Chernigovskaya E. V., Glazova M. V., Nikitina L. S. Audiogenic kindling activates expression of vasopressin in the hypothalamus of Krushinsky‐Molodkina rats genetically prone to reflex epilepsy // Journal of Neuroendocrinology. 2020. Vol. 32. No. 4.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1111/jne.12846
UR - https://doi.org/10.1111%2Fjne.12846
TI - Audiogenic kindling activates expression of vasopressin in the hypothalamus of Krushinsky‐Molodkina rats genetically prone to reflex epilepsy
T2 - Journal of Neuroendocrinology
AU - Chernigovskaya, Elena V.
AU - Harbachova, E. L.
AU - Glazova, M. V.
AU - Nikitina, Liubov S
PY - 2020
DA - 2020/04/01 00:00:00
PB - Wiley
IS - 4
VL - 32
SN - 0953-8194
SN - 1365-2826
ER -
Cite this
BibTex
Copy
@article{2020_Harbachova,
author = {Elena V. Chernigovskaya and E. L. Harbachova and M. V. Glazova and Liubov S Nikitina},
title = {Audiogenic kindling activates expression of vasopressin in the hypothalamus of Krushinsky‐Molodkina rats genetically prone to reflex epilepsy},
journal = {Journal of Neuroendocrinology},
year = {2020},
volume = {32},
publisher = {Wiley},
month = {apr},
url = {https://doi.org/10.1111%2Fjne.12846},
number = {4},
doi = {10.1111/jne.12846}
}