Transboundary and Emerging Diseases, volume 69, issue 5
Transborder molecular analysis of drug‐resistant tuberculosis in Mongolia and Eastern Siberia, Russia
Publication type: Journal Article
Publication date: 2022-03-30
Journal:
Transboundary and Emerging Diseases
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 4.3
ISSN: 18651674, 18651682
General Medicine
General Immunology and Microbiology
General Veterinary
Abstract
Eastern Siberia (Russia) and Mongolia are borderline regions in Asia with a high incidence of tuberculosis (TB). In this study, we investigated the transborder transmission of Mycobacterium tuberculosis with a focus on endemic and epidemic clones and drug resistance. M. tuberculosis isolates (287 from Mongolia and 754 from Russia) were collected using cross-sectional population-based surveys between 2010 and 2016. The isolates were genotyped using 24 variable number of tandem repeat (VNTR) loci and by testing of the key markers to discriminate within the Beijing genotype. All isolates were divided into 427 MIRU-types that were assigned to Lineage 2 (Beijing) and Lineage 4 (Ural, Haarlem, Latin American-Mediterranean [LAM], S, unclassified). The Beijing genotype was dominant in both countries (69% in Russia, 75% in Mongolia). However, the Beijing isolates differed significantly between the countries, in terms of the identified subtypes. LAM was the most common non-Beijing genotype (11.1% in Mongolia and 14.9% in Russia) and LAM isolates mostly belonged to the LAM-RUS branch in both countries. The MDR rate was higher in Russia than in Mongolia among newly diagnosed patients: 29.4% versus 5.6% (p < 0.001). In Mongolia, the MDR rate was similar in Beijing (29.7%) and non-Beijing (27.5%) genotypes. In Russia, a higher MDR rate was observed in (i) Beijing compared to non-Beijing (48.7% versus 38.3%, p = 0.03) and (ii) Beijing B0/W148 compared to Beijing Central Asian/Russian (63.4% versus 37.3%, p<0.001). In conclusion, the M. tuberculosis population structure in Mongolia was shaped by mainly historical interaction with China (dominance of the Beijing genotype) and Northern Eurasia (presence of the LAM-RUS branch). In contrast, the transborder transmission of M. tuberculosis since the 1990s between Mongolia and its neighbors has been negligible, and the adverse trends of MDR-TB in Russia did not impact the current situation in Mongolia. This article is protected by copyright. All rights reserved.
Citations by journals
|
1
|
|
|
Microorganisms
|
Microorganisms
1 publication, 11.11%
|
|
Infection, Genetics and Evolution
|
Infection, Genetics and Evolution
1 publication, 11.11%
|
|
Russian Journal of Infection and Immunity
|
Russian Journal of Infection and Immunity, 1, 11.11%
Russian Journal of Infection and Immunity
1 publication, 11.11%
|
|
International Journal of Molecular Sciences
|
International Journal of Molecular Sciences
1 publication, 11.11%
|
|
BMC Infectious Diseases
|
BMC Infectious Diseases
1 publication, 11.11%
|
|
Microbiology spectrum
|
Microbiology spectrum
1 publication, 11.11%
|
|
Journal of microbiology epidemiology immunobiology
|
Journal of microbiology epidemiology immunobiology
1 publication, 11.11%
|
|
Epidemiology and Vaccinal Prevention (Epidemiologiya i Vaktsinoprofilaktika)
|
Epidemiology and Vaccinal Prevention (Epidemiologiya i Vaktsinoprofilaktika)
1 publication, 11.11%
|
|
Molecular Phylogenetics and Evolution
|
Molecular Phylogenetics and Evolution
1 publication, 11.11%
|
|
1
|
Citations by publishers
|
1
2
|
|
|
Multidisciplinary Digital Publishing Institute (MDPI)
|
Multidisciplinary Digital Publishing Institute (MDPI)
2 publications, 22.22%
|
|
Elsevier
|
Elsevier
2 publications, 22.22%
|
|
Saint Petersburg Pasteur Institute
|
Saint Petersburg Pasteur Institute, 1, 11.11%
Saint Petersburg Pasteur Institute
1 publication, 11.11%
|
|
Springer Nature
|
Springer Nature
1 publication, 11.11%
|
|
American Society for Microbiology
|
American Society for Microbiology
1 publication, 11.11%
|
|
Central Research Institute for Epidemiology
|
Central Research Institute for Epidemiology
1 publication, 11.11%
|
|
National Association of the Specialists in Control of Health Care-Associated Infections
|
National Association of the Specialists in Control of Health Care-Associated Infections
1 publication, 11.11%
|
|
1
2
|
- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2022,2023,2024],"ids":[0,0,0],"codes":[0,0,0],"imageUrls":["","",""],"datasets":[{"label":"Citations number","data":[1,5,3],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6"],"percentage":["11.11","55.56","33.33"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Microorganisms","Infection, Genetics and Evolution","Russian Journal of Infection and Immunity","International Journal of Molecular Sciences","BMC Infectious Diseases","Microbiology spectrum","Journal of microbiology epidemiology immunobiology","Epidemiology and Vaccinal Prevention (Epidemiologiya i Vaktsinoprofilaktika)","Molecular Phylogenetics and Evolution"],"ids":[6197,14478,11248,14627,24948,17855,27070,29600,8801],"codes":[0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/VPE7q24PXoHr5SS2SqfEgxccSMUxWLfZINOX60uo_medium.webp","\/storage\/images\/resized\/HxgFXojL9GSWD86Qe827ZjqG8ciNkkviz42FIGJU_medium.webp","\/storage\/images\/resized\/wdrtfhwrizaWjy8CbCy4r1pFjYpLW6h7nXRRSOAt_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp"],"datasets":[{"label":"","data":[1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[11.11,11.11,11.11,11.11,11.11,11.11,11.11,11.11,11.11],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Multidisciplinary Digital Publishing Institute (MDPI)","Elsevier","Saint Petersburg Pasteur Institute","Springer Nature","American Society for Microbiology","Central Research Institute for Epidemiology","National Association of the Specialists in Control of Health Care-Associated Infections"],"ids":[202,17,3515,8,142,7217,7613],"codes":[0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/VPE7q24PXoHr5SS2SqfEgxccSMUxWLfZINOX60uo_medium.webp","\/storage\/images\/resized\/HxgFXojL9GSWD86Qe827ZjqG8ciNkkviz42FIGJU_medium.webp","\/storage\/images\/resized\/wdrtfhwrizaWjy8CbCy4r1pFjYpLW6h7nXRRSOAt_medium.webp"],"datasets":[{"label":"","data":[2,2,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[22.22,22.22,11.11,11.11,11.11,11.11,11.11],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}
Metrics
Cite this
GOST |
RIS |
BibTex
Cite this
GOST
Copy
Zhdanova S. et al. Transborder molecular analysis of drug‐resistant tuberculosis in Mongolia and Eastern Siberia, Russia // Transboundary and Emerging Diseases. 2022. Vol. 69. No. 5.
GOST all authors (up to 50)
Copy
Zhdanova S., Mokrousov I., Orlova E., Sinkov V., Ogarkov O. Transborder molecular analysis of drug‐resistant tuberculosis in Mongolia and Eastern Siberia, Russia // Transboundary and Emerging Diseases. 2022. Vol. 69. No. 5.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1111/tbed.14515
UR - https://doi.org/10.1111%2Ftbed.14515
TI - Transborder molecular analysis of drug‐resistant tuberculosis in Mongolia and Eastern Siberia, Russia
T2 - Transboundary and Emerging Diseases
AU - Mokrousov, Igor
AU - Orlova, Elizaveta
AU - Sinkov, Viacheslav
AU - Ogarkov, Oleg
AU - Zhdanova, Svetlana
PY - 2022
DA - 2022/03/30 00:00:00
PB - Wiley
IS - 5
VL - 69
SN - 1865-1674
SN - 1865-1682
ER -
Cite this
BibTex
Copy
@article{2022_Zhdanova,
author = {Igor Mokrousov and Elizaveta Orlova and Viacheslav Sinkov and Oleg Ogarkov and Svetlana Zhdanova},
title = {Transborder molecular analysis of drug‐resistant tuberculosis in Mongolia and Eastern Siberia, Russia},
journal = {Transboundary and Emerging Diseases},
year = {2022},
volume = {69},
publisher = {Wiley},
month = {mar},
url = {https://doi.org/10.1111%2Ftbed.14515},
number = {5},
doi = {10.1111/tbed.14515}
}