British Journal of Dermatology, volume 176, issue 3, pages 759-764
Long-term adherence to topical psoriasis treatment can be abysmal: a 1-year randomized intervention study using objective electronic adherence monitoring
H Alinia
1
,
S Moradi Tuchayi
1
,
J A Smith
1
,
I M Richardson
1
,
N. Bahrami
1, 2, 3
,
S C Jaros
1
,
L F Sandoval
1
,
M E Farhangian
1
,
K. L. Anderson
1
,
K E Huang
1
,
S R Feldman
1, 4, 5
1
Department of Dermatology (Center for Dermatology Research); Wake Forest School of Medicine; Medical Center Boulevard; Winston-Salem NC 27157-1071 U.S.A
|
2
3
Department of Radiology; Wake Forest School of Medicine; Medical Center Boulevard; Winston-Salem NC 27157-1071 U.S.A
|
4
Department of Pathology; Wake Forest School of Medicine; Medical Center Boulevard; Winston-Salem NC 27157-1071 U.S.A
|
5
Department of Public Health Sciences; Wake Forest School of Medicine; Medical Center Boulevard; Winston-Salem NC 27157-1071 U.S.A
|
Publication type: Journal Article
Publication date: 2016-11-29
Journal:
British Journal of Dermatology
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 10.3
ISSN: 00070963, 13652133
Dermatology
Abstract
Most people with psoriasis have limited disease that could be treated with topicals, but topical efficacy is limited by low short-term adherence. Psoriasis is a chronic disease, and long-term adherence is an even bigger problem.To determine how well medication is used in the long-term topical treatment of psoriasis and to assess the potential of an internet-based reporting intervention to improve treatment adherence and outcomes.An investigator-blinded, prospective study evaluated topical fluocinonide adherence in 40 patients with mild-to-moderate psoriasis over 12 months. Subjects were randomized in a 1 : 1 ratio to standard-of-care or internet-based reporting group. Adherence was objectively monitored with Medication Event Monitoring System® caps.Fifty per cent of subjects discontinued the treatment. Greater adherence was seen in the intervention group compared with the standard-of-care group (50% vs. 35%, P = 0·08). Psoriasis Area and Severity Index improved more in the intervention group at month 1 (1·61 vs. -0·12, P = 0·003), month 3 (2·50 vs. 0·79, P = 0·025) and month 12 (3·32 vs. 0·34, P = 0·038) than in the standard-of-care group.This study likely underestimates the challenge of long-term adherence, as adherence tends to be better in research studies than in clinical practice. This study also did not fully account for primary nonadherence. Adherence to topical treatment is low in the short term and decreased further in the long term, a considerable challenge for dermatologists to address. A reporting intervention may be one of the ways we can improve our patients' treatment outcomes.
Top-30
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Citations by publishers
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5
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15
20
25
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Wiley
21 publications, 31.82%
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14 publications, 21.21%
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5 publications, 7.58%
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SAGE
3 publications, 4.55%
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2 publications, 3.03%
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Frontiers Media S.A.
1 publication, 1.52%
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BMJ
1 publication, 1.52%
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Edizioni Minerva Medica
1 publication, 1.52%
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Almazov National Medical Research Centre
1 publication, 1.52%
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Wolters Kluwer Health
1 publication, 1.52%
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5
10
15
20
25
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Alinia H. et al. Long-term adherence to topical psoriasis treatment can be abysmal: a 1-year randomized intervention study using objective electronic adherence monitoring // British Journal of Dermatology. 2016. Vol. 176. No. 3. pp. 759-764.
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Alinia H., Moradi Tuchayi S., Smith J. A., Richardson I. M., Bahrami N., Jaros S. C., Sandoval L. F., Farhangian M. E., Anderson K. L., Huang K. E., Feldman S. R. Long-term adherence to topical psoriasis treatment can be abysmal: a 1-year randomized intervention study using objective electronic adherence monitoring // British Journal of Dermatology. 2016. Vol. 176. No. 3. pp. 759-764.
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TY - JOUR
DO - 10.1111/bjd.15085
UR - https://doi.org/10.1111/bjd.15085
TI - Long-term adherence to topical psoriasis treatment can be abysmal: a 1-year randomized intervention study using objective electronic adherence monitoring
T2 - British Journal of Dermatology
AU - Alinia, H
AU - Moradi Tuchayi, S
AU - Smith, J A
AU - Richardson, I M
AU - Jaros, S C
AU - Sandoval, L F
AU - Farhangian, M E
AU - Anderson, K. L.
AU - Huang, K E
AU - Bahrami, N.
AU - Feldman, S R
PY - 2016
DA - 2016/11/29
PB - Wiley
SP - 759-764
IS - 3
VL - 176
SN - 0007-0963
SN - 1365-2133
ER -
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@article{2016_Alinia,
author = {H Alinia and S Moradi Tuchayi and J A Smith and I M Richardson and S C Jaros and L F Sandoval and M E Farhangian and K. L. Anderson and K E Huang and N. Bahrami and S R Feldman},
title = {Long-term adherence to topical psoriasis treatment can be abysmal: a 1-year randomized intervention study using objective electronic adherence monitoring},
journal = {British Journal of Dermatology},
year = {2016},
volume = {176},
publisher = {Wiley},
month = {nov},
url = {https://doi.org/10.1111/bjd.15085},
number = {3},
pages = {759--764},
doi = {10.1111/bjd.15085}
}
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Alinia, H., et al. “Long-term adherence to topical psoriasis treatment can be abysmal: a 1-year randomized intervention study using objective electronic adherence monitoring.” British Journal of Dermatology, vol. 176, no. 3, Nov. 2016, pp. 759-764. https://doi.org/10.1111/bjd.15085.