Recent advances in antifungal drug development targeting lanosterol 14α‐demethylase ( CYP51 ): A comprehensive review with structural and molecular insights
Fungal infections are posing serious threat to healthcare system due to emerging resistance among available antifungal agents. Among available antifungal agents in clinical practice, azoles (diazole, 1,2,4‐triazole and tetrazole) remained most effective and widely prescribed antifungal agents. Now their associated side effects and emerging resistance pattern raised a need of new and potent antifungal agents. Lanosterol 14α‐demethylase (CYP51) is responsible for the oxidative removal of 14α‐methyl group of sterol precursors lanosterol and 24(28)‐methylene‐24,25‐dihydrolanosterol in ergosterol biosynthesis hence an essential component of fungal life cycle and prominent target for antifungal drug development. This review will shed light on various azole‐ as well as non‐azoles‐based derivatives as potential antifungal agents that target fungal CYP51. Review will provide deep insight about structure activity relationship, pharmacological outcomes, and interactions of derivatives with CYP51 at molecular level. It will help medicinal chemists working on antifungal development in designing more rational, potent, and safer antifungal agents by targeting fungal CYP51 for tackling emerging antifungal drug resistance.
Top-30
Journals
|
1
2
|
|
|
Chemistry and Biodiversity
2 publications, 7.69%
|
|
|
Journal of Fungi
1 publication, 3.85%
|
|
|
Infection and Drug Resistance
1 publication, 3.85%
|
|
|
Plant Pathology
1 publication, 3.85%
|
|
|
Antibiotics
1 publication, 3.85%
|
|
|
Oriental Journal Of Chemistry
1 publication, 3.85%
|
|
|
Biological Control
1 publication, 3.85%
|
|
|
Natural Product Research
1 publication, 3.85%
|
|
|
Journal of Medicinal Chemistry
1 publication, 3.85%
|
|
|
Analytical Chemistry Letters
1 publication, 3.85%
|
|
|
Journal of the Science of Food and Agriculture
1 publication, 3.85%
|
|
|
Chemical Biology and Drug Design
1 publication, 3.85%
|
|
|
Biochimie
1 publication, 3.85%
|
|
|
Aquatic Toxicology
1 publication, 3.85%
|
|
|
European Journal of Medicinal Chemistry
1 publication, 3.85%
|
|
|
Cell Biochemistry and Biophysics
1 publication, 3.85%
|
|
|
International Journal of Biological Macromolecules
1 publication, 3.85%
|
|
|
Scientific Reports
1 publication, 3.85%
|
|
|
Pharmaceuticals
1 publication, 3.85%
|
|
|
Catalysts
1 publication, 3.85%
|
|
|
RSC Advances
1 publication, 3.85%
|
|
|
International Journal of Molecular Sciences
1 publication, 3.85%
|
|
|
Future Microbiology
1 publication, 3.85%
|
|
|
Microbial Pathogenesis
1 publication, 3.85%
|
|
|
Bioorganic Chemistry
1 publication, 3.85%
|
|
|
1
2
|
Publishers
|
1
2
3
4
5
6
7
|
|
|
Elsevier
7 publications, 26.92%
|
|
|
MDPI
5 publications, 19.23%
|
|
|
Wiley
5 publications, 19.23%
|
|
|
Taylor & Francis
4 publications, 15.38%
|
|
|
Springer Nature
2 publications, 7.69%
|
|
|
Oriental Scientific Publishing Company
1 publication, 3.85%
|
|
|
American Chemical Society (ACS)
1 publication, 3.85%
|
|
|
Royal Society of Chemistry (RSC)
1 publication, 3.85%
|
|
|
1
2
3
4
5
6
7
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.