The Distribution of Chlorpromazine between Plasma and Erythrocytes
Publication type: Journal Article
Publication date: 2009-04-27
PubMed ID:
7468230
Pharmacology
Toxicology
Abstract
Chlorpromazine is found to be taken up by the erythrocytes in a dissociable binding similar to that of the plasma protein binding so that an equilibrium is attained between these binding sites. The plasma/cell ratio is on an average 2 but is subject to large interindividual variations. This ratio is only moderately influenced by the presence of other drugs and anticoagulants in the blood. The consequences of the cell binding of drugs for the analytical result when using plasma or whole blood and the evaluation of blood concentrations of their relation to the therapeutic effect are discussed.
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GOST
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Lund A. The Distribution of Chlorpromazine between Plasma and Erythrocytes // Acta Pharmacologica et Toxicologica. 2009. Vol. 47. No. 4. pp. 300-304.
GOST all authors (up to 50)
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Lund A. The Distribution of Chlorpromazine between Plasma and Erythrocytes // Acta Pharmacologica et Toxicologica. 2009. Vol. 47. No. 4. pp. 300-304.
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RIS
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TY - JOUR
DO - 10.1111/j.1600-0773.1980.tb03658.x
UR - https://doi.org/10.1111/j.1600-0773.1980.tb03658.x
TI - The Distribution of Chlorpromazine between Plasma and Erythrocytes
T2 - Acta Pharmacologica et Toxicologica
AU - Lund, Alf
PY - 2009
DA - 2009/04/27
PB - Wiley
SP - 300-304
IS - 4
VL - 47
PMID - 7468230
SN - 0001-6683
ER -
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BibTex (up to 50 authors)
Copy
@article{2009_Lund,
author = {Alf Lund},
title = {The Distribution of Chlorpromazine between Plasma and Erythrocytes},
journal = {Acta Pharmacologica et Toxicologica},
year = {2009},
volume = {47},
publisher = {Wiley},
month = {apr},
url = {https://doi.org/10.1111/j.1600-0773.1980.tb03658.x},
number = {4},
pages = {300--304},
doi = {10.1111/j.1600-0773.1980.tb03658.x}
}
Cite this
MLA
Copy
Lund, Alf. “The Distribution of Chlorpromazine between Plasma and Erythrocytes.” Acta Pharmacologica et Toxicologica, vol. 47, no. 4, Apr. 2009, pp. 300-304. https://doi.org/10.1111/j.1600-0773.1980.tb03658.x.