Open Access
An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control
1
Publication type: Journal Article
Publication date: 2014-10-03
scimago Q1
wos Q1
SJR: 10.416
CiteScore: 48.4
Impact factor: 45.8
ISSN: 00368075, 10959203
PubMed ID:
25278615
Multidisciplinary
Abstract
Controlling stem cells and their niches
Adult organs such as the intestines and skin continually renew themselves every few days or weeks. In several mammalian tissues, this renewal relies on Wnt signaling. Clevers et al. review this crucial role in stem cell self renewal. Wnt plays a pivotal role in tissue regeneration even in the earliest animals. Wnt proteins function mainly as short-range signals between adjacent cells. The short-range, spatially-constrained nature of Wnt signals underpins mammalian stem cell niche architecture and tissue self-organization.
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1.2k
Total citations:
1165
Citations from 2024:
183
(15.71%)
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GOST
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Clevers H., Loh K. M., Nusse R. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control // Science. 2014. Vol. 346. No. 6205.
GOST all authors (up to 50)
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Clevers H., Loh K. M., Nusse R. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control // Science. 2014. Vol. 346. No. 6205.
Cite this
RIS
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TY - JOUR
DO - 10.1126/science.1248012
UR - https://doi.org/10.1126/science.1248012
TI - An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control
T2 - Science
AU - Clevers, Hans
AU - Loh, Kyle M.
AU - Nusse, Roel
PY - 2014
DA - 2014/10/03
PB - American Association for the Advancement of Science (AAAS)
IS - 6205
VL - 346
PMID - 25278615
SN - 0036-8075
SN - 1095-9203
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2014_Clevers,
author = {Hans Clevers and Kyle M. Loh and Roel Nusse},
title = {An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control},
journal = {Science},
year = {2014},
volume = {346},
publisher = {American Association for the Advancement of Science (AAAS)},
month = {oct},
url = {https://doi.org/10.1126/science.1248012},
number = {6205},
doi = {10.1126/science.1248012}
}