Open Access
Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity
Ryan G Gaudet
1
,
Anna Sintsova*
1
,
Carolyn M Buckwalter
1
,
Nelly Leung
1
,
Alan Cochrane
1
,
Jianjun Li
2
,
Andrew D. Cox
2
,
Jason Moffat
1, 3
,
Scott D. Gray-Owen
1
2
Vaccine Program, National Research Council, Ottawa, ON, Canada K1A 0R6.
|
Publication type: Journal Article
Publication date: 2015-06-12
scimago Q1
wos Q1
SJR: 10.416
CiteScore: 48.4
Impact factor: 45.8
ISSN: 00368075, 10959203
PubMed ID:
26068852
Multidisciplinary
Abstract
Detecting Gramnegative bacteria
Invariant molecules specific to different classes of microbes, but not expressed by eukaryotic cells, alert the immune system to a potential invader. Gaudet et al. identified one such molecule expressed by a variety of Gram-negative bacteria: the monosaccharide heptose-1,7-bisphosphate (HBP) (see the Perspective by Brubaker and Monack). HBP is an intermediate in the synthesis of lipopolysaccharide, a major component of bacterial cell walls. Rather than alerting the immune system through traditional pathogen detection pathways, such as Toll-like receptors, HBP signals through the host protein TIFA (TRAF-interacting protein with forkhead-associated domain), which activates both innate and adaptive immune responses to control the infection.
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146
Total citations:
146
Citations from 2024:
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(15.06%)
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GOST
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Gaudet R. G. et al. Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity // Science. 2015. Vol. 348. No. 6240. pp. 1251-1255.
GOST all authors (up to 50)
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Gaudet R. G., Sintsova* A., Buckwalter C. M., Leung N., Cochrane A., Li J., Cox A. D., Moffat J., Gray-Owen S. D. Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity // Science. 2015. Vol. 348. No. 6240. pp. 1251-1255.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1126/science.aaa4921
UR - https://doi.org/10.1126/science.aaa4921
TI - Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity
T2 - Science
AU - Gaudet, Ryan G
AU - Sintsova*, Anna
AU - Buckwalter, Carolyn M
AU - Leung, Nelly
AU - Cochrane, Alan
AU - Li, Jianjun
AU - Cox, Andrew D.
AU - Moffat, Jason
AU - Gray-Owen, Scott D.
PY - 2015
DA - 2015/06/12
PB - American Association for the Advancement of Science (AAAS)
SP - 1251-1255
IS - 6240
VL - 348
PMID - 26068852
SN - 0036-8075
SN - 1095-9203
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2015_Gaudet,
author = {Ryan G Gaudet and Anna Sintsova* and Carolyn M Buckwalter and Nelly Leung and Alan Cochrane and Jianjun Li and Andrew D. Cox and Jason Moffat and Scott D. Gray-Owen},
title = {Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity},
journal = {Science},
year = {2015},
volume = {348},
publisher = {American Association for the Advancement of Science (AAAS)},
month = {jun},
url = {https://doi.org/10.1126/science.aaa4921},
number = {6240},
pages = {1251--1255},
doi = {10.1126/science.aaa4921}
}
Cite this
MLA
Copy
Gaudet, Ryan G., et al. “Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity.” Science, vol. 348, no. 6240, Jun. 2015, pp. 1251-1255. https://doi.org/10.1126/science.aaa4921.