Open Access
Science, volume 352, issue 6293, pages 1535-1542
A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion
George M H Birchenough
1
,
Elisabeth E L Nyström
1
,
Malin E. V. JOHANSSON
1
,
Gunnar C. HANSSON
1
Publication type: Journal Article
Publication date: 2016-06-24
Journal:
Science
scimago Q1
SJR: 11.902
CiteScore: 61.1
Impact factor: 44.7
ISSN: 00368075, 10959203
PubMed ID:
27339979
Multidisciplinary
Abstract
Mounting the intestinal barricades
Gut microbiota are important for health and well-being, but they need to be kept under control and prevented from doing any harm. Birchenough et al. investigated the microbial molecules that trigger protective mucus secretion from a class of goblet cells in the colon. Once the molecules are detected, an alarm signal is transmitted from these cells via innate immune signal mediators and inflammasome components to adjacent cells, generating more mucus and repelling the invaders. Subsequently, the sentinel goblet cells are expelled from the epithelium and their remains may also add to the protective barricade.
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GOST
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Birchenough G. M. H. et al. A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion // Science. 2016. Vol. 352. No. 6293. pp. 1535-1542.
GOST all authors (up to 50)
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Birchenough G. M. H., Nyström E. E. L., JOHANSSON M. E. V., HANSSON G. C. A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion // Science. 2016. Vol. 352. No. 6293. pp. 1535-1542.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1126/science.aaf7419
UR - https://doi.org/10.1126/science.aaf7419
TI - A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion
T2 - Science
AU - Birchenough, George M H
AU - Nyström, Elisabeth E L
AU - JOHANSSON, Malin E. V.
AU - HANSSON, Gunnar C.
PY - 2016
DA - 2016/06/24
PB - American Association for the Advancement of Science (AAAS)
SP - 1535-1542
IS - 6293
VL - 352
PMID - 27339979
SN - 0036-8075
SN - 1095-9203
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2016_Birchenough,
author = {George M H Birchenough and Elisabeth E L Nyström and Malin E. V. JOHANSSON and Gunnar C. HANSSON},
title = {A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion},
journal = {Science},
year = {2016},
volume = {352},
publisher = {American Association for the Advancement of Science (AAAS)},
month = {jun},
url = {https://doi.org/10.1126/science.aaf7419},
number = {6293},
pages = {1535--1542},
doi = {10.1126/science.aaf7419}
}
Cite this
MLA
Copy
Birchenough, George M. H., et al. “A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion.” Science, vol. 352, no. 6293, Jun. 2016, pp. 1535-1542. https://doi.org/10.1126/science.aaf7419.
Found error?
Found error?
Journal
scimago Q1
SJR
11.902
CiteScore
61.1
Impact factor
44.7
ISSN
00368075
(Print)
10959203
(Electronic)