Open Access
The biology , function , and biomedical applications of exosomes
Publication type: Journal Article
Publication date: 2020-02-07
scimago Q1
wos Q1
SJR: 10.416
CiteScore: 48.4
Impact factor: 45.8
ISSN: 00368075, 10959203
PubMed ID:
32029601
Multidisciplinary
Abstract
Clinical uses of cellular communication
Exosomes are a type of extracellular vesicle that contain constituents (protein, DNA, and RNA) of the cells that secrete them. They are taken up by distant cells, where they can affect cell function and behavior. Intercellular communication through exosomes seems to be involved in the pathogenesis of various disorders, including cancer, neurodegeneration, and inflammatory diseases. In a Review, Kalluri and LeBleu discuss the biogenesis and function of exosomes in disease, highlighting areas where more research is needed. They also discuss the potential clinical applications of exosome profiling for diagnostics and exosome-mediated delivery of therapeutics to target disease cells.
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RIS
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TY - JOUR
DO - 10.1126/science.aau6977
UR - https://doi.org/10.1126/science.aau6977
TI - The biology , function , and biomedical applications of exosomes
T2 - Science
AU - Kalluri, Raghu
AU - LeBleu, Valerie
PY - 2020
DA - 2020/02/07
PB - American Association for the Advancement of Science (AAAS)
IS - 6478
VL - 367
PMID - 32029601
SN - 0036-8075
SN - 1095-9203
ER -
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@article{2020_Kalluri,
author = {Raghu Kalluri and Valerie LeBleu},
title = {The biology , function , and biomedical applications of exosomes},
journal = {Science},
year = {2020},
volume = {367},
publisher = {American Association for the Advancement of Science (AAAS)},
month = {feb},
url = {https://doi.org/10.1126/science.aau6977},
number = {6478},
doi = {10.1126/science.aau6977}
}