Open Access
An intercrypt subpopulation of goblet cells is essential for colonic mucus barrier function
Elisabeth E L Nyström
1
,
Beatriz Martinez Abad
1
,
Liisa Arike
1
,
George Birchenough
1
,
Eric B Nonnecke
2
,
Patricia Castillo
2
,
Frida Svensson
1
,
Charles L. Bevins
2
,
Gunnar C. Hansson
1
,
M. Johansson
1
Publication type: Journal Article
Publication date: 2021-04-16
scimago Q1
wos Q1
SJR: 10.416
CiteScore: 48.4
Impact factor: 45.8
ISSN: 00368075, 10959203
PubMed ID:
33859001
Multidisciplinary
Abstract
Goblet cell diversity
An adult human has a gut surface area averaging 30 square meters that is bombarded daily by xenobiotics and microorganisms. Mucus synthesized by goblet cells supplies a protective barrier coating. Nyström et al. discovered that goblet cells are not all the same along the length of the gut; rather, they form different functional populations depending on location. Small-intestine mucus is laced with antimicrobial peptides and is permeable to small molecules; downstream, thicker mucus is generated that excludes bacteria and xenobiotics. Mucus oozes in thick plumes from goblet cells within the crypts to shield the stem cell niche. Between the crypts lie highly differentiated goblet cells producing permeable mucus. Together, both types of mucus form a network that shelters the gut epithelium. If, however, the intercrypt goblet cells become dysfunctional, the exposed epithelium is exposed to bacteria and vulnerable to developing colitis.
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266
Total citations:
266
Citations from 2024:
140
(52.63%)
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Nyström E. E. L. et al. An intercrypt subpopulation of goblet cells is essential for colonic mucus barrier function // Science. 2021. Vol. 372. No. 6539.
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Nyström E. E. L., Martinez Abad B., Arike L., Birchenough G., Nonnecke E. B., Castillo P., Svensson F., Bevins C. L., Hansson G. C., Johansson M. An intercrypt subpopulation of goblet cells is essential for colonic mucus barrier function // Science. 2021. Vol. 372. No. 6539.
Cite this
RIS
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TY - JOUR
DO - 10.1126/science.abb1590
UR - https://doi.org/10.1126/science.abb1590
TI - An intercrypt subpopulation of goblet cells is essential for colonic mucus barrier function
T2 - Science
AU - Nyström, Elisabeth E L
AU - Martinez Abad, Beatriz
AU - Arike, Liisa
AU - Birchenough, George
AU - Nonnecke, Eric B
AU - Castillo, Patricia
AU - Svensson, Frida
AU - Bevins, Charles L.
AU - Hansson, Gunnar C.
AU - Johansson, M.
PY - 2021
DA - 2021/04/16
PB - American Association for the Advancement of Science (AAAS)
IS - 6539
VL - 372
PMID - 33859001
SN - 0036-8075
SN - 1095-9203
ER -
Cite this
BibTex (up to 50 authors)
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@article{2021_Nyström,
author = {Elisabeth E L Nyström and Beatriz Martinez Abad and Liisa Arike and George Birchenough and Eric B Nonnecke and Patricia Castillo and Frida Svensson and Charles L. Bevins and Gunnar C. Hansson and M. Johansson},
title = {An intercrypt subpopulation of goblet cells is essential for colonic mucus barrier function},
journal = {Science},
year = {2021},
volume = {372},
publisher = {American Association for the Advancement of Science (AAAS)},
month = {apr},
url = {https://doi.org/10.1126/science.abb1590},
number = {6539},
doi = {10.1126/science.abb1590}
}