Open Access

Science

, volume 374 , issue 6566 , pages 439-448

Identification of a choroid plexus vascular barrier closing during intestinal inflammation

Sara Carloni ^{1, 2}

Alice Bertocchi ²

Sara Mancinelli ^{1, 2}

Martina Bellini ^{1, 2}

Marco Erreni ^{1, 2}

Antonella Borreca ^{2, 3}

Daniele Braga ²

Silvia Giugliano ²

Alessandro M Mozzarelli ^{1, 2}

Daria Manganaro ⁴

Daniel Fernandez Perez ⁴

Federico S. Colombo ²

Antonio Di Sabatino ⁵

Diego Pasini ^{4, 6}

Giuseppe Penna ²

Michela Matteoli ^{2, 3}

S. Lodato ^{1, 2}

Maria Rescigno ^{1, 2}

Hide authors affiliations Show authors affiliations: 6 affiliations

Humanitas University, Department of Biomedical Sciences, 20072 Pieve Emanuele (Milan), Italy. |

IRCCS Humanitas Research Hospital, 20089 Rozzano, Milan, Italy. |

Institute of Neuroscience, National Research Council, c/o Humanitas Research Hospital, 20089 Rozzano, Milan, Italy. |

⁴

Department of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, 20139 Milan, Italy.

Istituti di Ricovero e Cura a Carattere Scientifico

European Institute of Oncology

⁵

Department of Internal Medicine, San Matteo Hospital Foundation, University of Pavia, 27100 Pavia, Italy. |

⁶

Department of Health Sciences, University of Milan, 20142 Milan, Italy. |

Publication type: Journal Article

Publication date: 2021-10-22

American Association for the Advancement of Science (AAAS)

Science

scimago Q1

wos Q1

SJR: 10.416

CiteScore: 48.4

Impact factor: 45.8

ISSN: 00368075, 10959203

DOI: 10.1126/science.abc6108

Copy DOI

PubMed ID: 34672740

Multidisciplinary

Abstract

Locking down access to the brain

Inflammatory bowel disease is best known for intestinal symptoms but can also cause a variety of extraintestinal manifestations in other organs. It can also be associated with cognitive and psychiatric effects, including anxiety and depression. Using mouse models of intestinal inflammation, Carloni et al . uncovered a potential pathogenic link between these aspects of inflammatory bowel disease. The inflammatory process causes the gut vascular barrier to become more permeable, resulting in the spread of inflammation beyond the intestine, while the vascular barrier in the choroid plexus shuts down, helping protect the brain from inflammation but also potentially impairing communication between organs and impairing some brain functions. —YN

Found

1 citation

Mei Linghan

2 publications, 6 citations

h-index: 2

University of Chicago

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GOST Copy

Carloni S. et al. Identification of a choroid plexus vascular barrier closing during intestinal inflammation // Science. 2021. Vol. 374. No. 6566. pp. 439-448.

GOST all authors (up to 50) Copy

Carloni S., Bertocchi A., Mancinelli S., Bellini M., Erreni M., Borreca A., Braga D., Giugliano S., Mozzarelli A. M., Manganaro D., Fernandez Perez D., Colombo F. S., Sabatino A. D., Pasini D., Penna G., Matteoli M., Lodato S., Rescigno M. Identification of a choroid plexus vascular barrier closing during intestinal inflammation // Science. 2021. Vol. 374. No. 6566. pp. 439-448.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1126/science.abc6108

UR - https://doi.org/10.1126/science.abc6108

TI - Identification of a choroid plexus vascular barrier closing during intestinal inflammation

T2 - Science

AU - Carloni, Sara

AU - Bertocchi, Alice

AU - Mancinelli, Sara

AU - Bellini, Martina

AU - Erreni, Marco

AU - Borreca, Antonella

AU - Braga, Daniele

AU - Giugliano, Silvia

AU - Mozzarelli, Alessandro M

AU - Manganaro, Daria

AU - Fernandez Perez, Daniel

AU - Colombo, Federico S.

AU - Sabatino, Antonio Di

AU - Pasini, Diego

AU - Penna, Giuseppe

AU - Matteoli, Michela

AU - Lodato, S.

AU - Rescigno, Maria

PY - 2021

DA - 2021/10/22

PB - American Association for the Advancement of Science (AAAS)

SP - 439-448

IS - 6566

VL - 374

PMID - 34672740

SN - 0036-8075

SN - 1095-9203

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2021_Carloni,

author = {Sara Carloni and Alice Bertocchi and Sara Mancinelli and Martina Bellini and Marco Erreni and Antonella Borreca and Daniele Braga and Silvia Giugliano and Alessandro M Mozzarelli and Daria Manganaro and Daniel Fernandez Perez and Federico S. Colombo and Antonio Di Sabatino and Diego Pasini and Giuseppe Penna and Michela Matteoli and S. Lodato and Maria Rescigno},

title = {Identification of a choroid plexus vascular barrier closing during intestinal inflammation},

journal = {Science},

year = {2021},

volume = {374},

publisher = {American Association for the Advancement of Science (AAAS)},

month = {oct},

url = {https://doi.org/10.1126/science.abc6108},

number = {6566},

pages = {439--448},

doi = {10.1126/science.abc6108}

}

MLA

Cite this

MLA Copy

Carloni, Sara, et al. “Identification of a choroid plexus vascular barrier closing during intestinal inflammation.” Science, vol. 374, no. 6566, Oct. 2021, pp. 439-448. https://doi.org/10.1126/science.abc6108.

Publisher

American Association for the Advancement of Science (AAAS)

Journal

Science

scimago Q1

wos Q1

SJR

10.416

CiteScore

48.4

Impact factor

45.8

ISSN

00368075 (Print)

10959203 (Electronic)