Open Access

Science, volume 371, issue 6530

Network-based screen in iPSC-derived cells reveals therapeutic candidate for heart valve disease

Theodoris Christina V ^{1, 2, 3}

Zhou Ping ^{1, 3}

Liu Lei ^{1, 3}

Zhang Yu ^{1, 3}

NISHINO TOMOHIRO ^{1, 3}

Huang Yu ^{1, 3}

Kostina A.A. ⁴

Ranade Sanjeev S. ^{1, 3}

Gifford Casey ^{1, 3}

Uspenskiy Vladimir ⁵

Malashicheva Anna В. ^{4, 5, 6}

Ding Sheng ^{1, 3, 7}

Srivastava Deepak ^{1, 3, 8}

Hide authors affiliations Show authors affiliations: 8 affiliations

Roddenberry Stem Cell Center, Gladstone Institutes, San Francisco, CA, USA. |

Program in Developmental and Stem Cell Biology (DSCB), University of California, San Francisco (UCSF), San Francisco, CA, USA. |

Gladstone Institute of Cardiovascular Disease, San Francisco, CA, USA. |

⁴

Institute of Cytology, Russian Academy of Sciences, Saint Petersburg, Russia. |

⁵

Almazov Federal Medical Research Centre, Saint Petersburg, Russia. |

⁶

Saint Petersburg State University, Saint Petersburg, Russia. |

⁷

Department of Pharmaceutical Chemistry, UCSF, San Francisco, CA, USA. |

⁸

Department of Pediatrics, Department of Biochemistry and Biophysics, UCSF, San Francisco, CA, USA. |

Publication type: Journal Article

Publication date: 2021-02-12

American Association for the Advancement of Science (AAAS)

Journal: Science

Quartile SCImago

Quartile WOS

Impact factor: 56.9

ISSN: 00368075, 10959203

DOI: 10.1126/science.abd0724

Copy DOI

PubMed ID: 33303684

Multidisciplinary

Abstract

Machine learning for medicine

Small-molecule screens aimed at identifying therapeutic candidates traditionally search for molecules that affect one to several outputs at most, limiting discovery of true disease-modifying drugs. Theodoris et al. developed a machine-learning approach to identify small molecules that broadly correct gene networks dysregulated in a human induced pluripotent stem cell disease model of a common form of heart disease involving the aortic valve. Gene network correction by the most efficacious therapeutic candidate generalized to primary aortic valve cells derived from more than 20 patients with sporadic aortic valve disease and prevented aortic valve disease in vivo in a mouse model.

Science , this issue p. eabd0724

By date By citations

Citations by journals

	1 2 3 4
Frontiers in Cardiovascular Medicine	Frontiers in Cardiovascular Medicine, 4, 7.84% Frontiers in Cardiovascular Medicine 4 publications, 7.84%
Circulation Research	Circulation Research, 2, 3.92% Circulation Research 2 publications, 3.92%
Frontiers in Cell and Developmental Biology	Frontiers in Cell and Developmental Biology, 2, 3.92% Frontiers in Cell and Developmental Biology 2 publications, 3.92%
Nature	Nature, 2, 3.92% Nature 2 publications, 3.92%
Biophysics Reviews	Biophysics Reviews, 1, 1.96% Biophysics Reviews 1 publication, 1.96%
Arteriosclerosis, Thrombosis, and Vascular Biology	Arteriosclerosis, Thrombosis, and Vascular Biology, 1, 1.96% Arteriosclerosis, Thrombosis, and Vascular Biology 1 publication, 1.96%
Molecular Medicine Reports	Molecular Medicine Reports, 1, 1.96% Molecular Medicine Reports 1 publication, 1.96%
Current Opinion in Cardiology	Current Opinion in Cardiology, 1, 1.96% Current Opinion in Cardiology 1 publication, 1.96%
Circulation Journal	Circulation Journal, 1, 1.96% Circulation Journal 1 publication, 1.96%
Pharmaceuticals	Pharmaceuticals, 1, 1.96% Pharmaceuticals 1 publication, 1.96%
Journal of Cardiovascular Development and Disease	Journal of Cardiovascular Development and Disease, 1, 1.96% Journal of Cardiovascular Development and Disease 1 publication, 1.96%
Frontiers in Aging	Frontiers in Aging, 1, 1.96% Frontiers in Aging 1 publication, 1.96%
Frontiers in Genetics	Frontiers in Genetics, 1, 1.96% Frontiers in Genetics 1 publication, 1.96%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 1, 1.96% International Journal of Molecular Sciences 1 publication, 1.96%
Nature Reviews Cardiology	Nature Reviews Cardiology, 1, 1.96% Nature Reviews Cardiology 1 publication, 1.96%
Kardiologe	Kardiologe, 1, 1.96% Kardiologe 1 publication, 1.96%
Archives of Toxicology	Archives of Toxicology, 1, 1.96% Archives of Toxicology 1 publication, 1.96%
Stem Cell Reviews and Reports	Stem Cell Reviews and Reports, 1, 1.96% Stem Cell Reviews and Reports 1 publication, 1.96%
Signal Transduction and Targeted Therapy	Signal Transduction and Targeted Therapy, 1, 1.96% Signal Transduction and Targeted Therapy 1 publication, 1.96%
Cell Reports	Cell Reports, 1, 1.96% Cell Reports 1 publication, 1.96%
Stem Cell Reports	Stem Cell Reports, 1, 1.96% Stem Cell Reports 1 publication, 1.96%
Pharmacological Research - Modern Chinese Medicine	Pharmacological Research - Modern Chinese Medicine, 1, 1.96% Pharmacological Research - Modern Chinese Medicine 1 publication, 1.96%
Quantum Science and Technology	Quantum Science and Technology, 1, 1.96% Quantum Science and Technology 1 publication, 1.96%
Military Medical Research	Military Medical Research, 1, 1.96% Military Medical Research 1 publication, 1.96%
Nature Reviews Bioengineering	Nature Reviews Bioengineering, 1, 1.96% Nature Reviews Bioengineering 1 publication, 1.96%
Birth Defects Research	Birth Defects Research, 1, 1.96% Birth Defects Research 1 publication, 1.96%
Bioinformatics	Bioinformatics, 1, 1.96% Bioinformatics 1 publication, 1.96%
Cardiovascular Research	Cardiovascular Research, 1, 1.96% Cardiovascular Research 1 publication, 1.96%
Science advances	Science advances, 1, 1.96% Science advances 1 publication, 1.96%
	1 2 3 4

Citations by publishers

	2 4 6 8 10
Springer Nature	Springer Nature, 10, 19.61% Springer Nature 10 publications, 19.61%
Frontiers Media S.A.	Frontiers Media S.A., 9, 17.65% Frontiers Media S.A. 9 publications, 17.65%
Elsevier	Elsevier, 5, 9.8% Elsevier 5 publications, 9.8%
Wolters Kluwer Health	Wolters Kluwer Health, 4, 7.84% Wolters Kluwer Health 4 publications, 7.84%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 3, 5.88% Multidisciplinary Digital Publishing Institute (MDPI) 3 publications, 5.88%
Oxford University Press	Oxford University Press, 2, 3.92% Oxford University Press 2 publications, 3.92%
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 2, 3.92% Cold Spring Harbor Laboratory 2 publications, 3.92%
American Institute of Physics (AIP)	American Institute of Physics (AIP), 1, 1.96% American Institute of Physics (AIP) 1 publication, 1.96%
Spandidos Publications	Spandidos Publications, 1, 1.96% Spandidos Publications 1 publication, 1.96%
The Japanese Circulation Society	The Japanese Circulation Society, 1, 1.96% The Japanese Circulation Society 1 publication, 1.96%
IOP Publishing	IOP Publishing, 1, 1.96% IOP Publishing 1 publication, 1.96%
Wiley	Wiley, 1, 1.96% Wiley 1 publication, 1.96%
American Association for the Advancement of Science (AAAS)	American Association for the Advancement of Science (AAAS), 1, 1.96% American Association for the Advancement of Science (AAAS) 1 publication, 1.96%
Hindawi Limited	Hindawi Limited, 1, 1.96% Hindawi Limited 1 publication, 1.96%
American Diabetes Association	American Diabetes Association, 1, 1.96% American Diabetes Association 1 publication, 1.96%
NII KPSSZ	NII KPSSZ, 1, 1.96% NII KPSSZ 1 publication, 1.96%
IGI Global	IGI Global, 1, 1.96% IGI Global 1 publication, 1.96%
	2 4 6 8 10

We do not take into account publications that without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
Statistics recalculated weekly.

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GOST Copy

Theodoris C. V. et al. Network-based screen in iPSC-derived cells reveals therapeutic candidate for heart valve disease // Science. 2021. Vol. 371. No. 6530.

GOST all authors (up to 50) Copy

Theodoris C. V., Zhou P., Liu L., Zhang Yu., NISHINO T., Huang Yu., Kostina A., Ranade S. S., Gifford C., Uspenskiy V., Malashicheva A. В., Ding S., Srivastava D. Network-based screen in iPSC-derived cells reveals therapeutic candidate for heart valve disease // Science. 2021. Vol. 371. No. 6530.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1126/science.abd0724

UR - https://doi.org/10.1126%2Fscience.abd0724

TI - Network-based screen in iPSC-derived cells reveals therapeutic candidate for heart valve disease

T2 - Science

AU - Theodoris, Christina V

AU - Zhou, Ping

AU - Liu, Lei

AU - Zhang, Yu

AU - NISHINO, TOMOHIRO

AU - Huang, Yu

AU - Kostina, A.A.

AU - Ranade, Sanjeev S.

AU - Gifford, Casey

AU - Uspenskiy, Vladimir

AU - Malashicheva, Anna В.

AU - Ding, Sheng

AU - Srivastava, Deepak

PY - 2021

DA - 2021/02/12 00:00:00

PB - American Association for the Advancement of Science (AAAS)

IS - 6530

VL - 371

PMID - 33303684

SN - 0036-8075

SN - 1095-9203

ER -

BibTex

Cite this

BibTex Copy

@article{2021_Theodoris,

author = {Christina V Theodoris and Ping Zhou and Lei Liu and Yu Zhang and TOMOHIRO NISHINO and Yu Huang and A.A. Kostina and Sanjeev S. Ranade and Casey Gifford and Vladimir Uspenskiy and Anna В. Malashicheva and Sheng Ding and Deepak Srivastava},

title = {Network-based screen in iPSC-derived cells reveals therapeutic candidate for heart valve disease},

journal = {Science},

year = {2021},

volume = {371},

publisher = {American Association for the Advancement of Science (AAAS)},

month = {feb},

url = {https://doi.org/10.1126%2Fscience.abd0724},

number = {6530},

doi = {10.1126/science.abd0724}

}

Found error?

Publisher

American Association for the Advancement of Science (AAAS)

Journal

Science

Quartile SCImago

Quartile WOS

Impact factor

56.9

ISSN

00368075 (Print)
10959203 (Electronic)

Labs

Laboratory of Regenerative Biomedicine

Profiles

Malashicheva, Anna B