Open Access
Science, volume 370, issue 6523, pages 1473-1479
An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike
Michael Schoof
1, 2
,
Bryan Faust
1, 2, 3, 4
,
Reuben A Saunders
1, 5
,
Smriti Sangwan
1, 2
,
Nick Hoppe
3, 4
,
Morgane Boone
1, 2
,
Christian B Billesbølle
3, 4
,
C. M. Azumaya
4
,
H. Kratochvil
4
,
Marcell Zimanyi
1, 2
,
Ishan Deshpande
3, 4
,
Jiahao Liang
3
,
Kim Cuong Nguyen
4
,
Cynthia M Chio
4
,
Gregory E Merz
4
,
Michael C. Thompson
4
,
Devan Diwanji
4
,
Kaitlin Schaefer
4
,
Aditya A Anand
1, 2
,
Niv Dobzinski
1, 2
,
Beth S. Zha
7
,
Camille R. Simoneau
8, 9, 10
,
Kristoffer E Leon
8, 9, 10
,
Kris M White
11, 12
,
Un Seng Chio
4
,
Meghna Gupta
4
,
M Jin
4
,
Fei Li
4
,
Yanxin Liu
4
,
Kaihua Zhang
4
,
David Bulkley
4
,
Ming Sun
4
,
Joel M Smith
4
,
Alexandrea Rizo
4
,
Frank R Moss
4
,
Axel F. Brilot
4
,
Sergei Pourmal
4
,
R Trenker
4
,
Sayan Gupta
13
,
Benjamin Barsi Rhyne
3
,
Vladislav Belyy
1, 2
,
Andrew W Barile Hill
14
,
Silke Nock
1, 2
,
YUWEI LIU
1, 2
,
Nevan J. Krogan
4, 5, 8, 9
,
Corie Y. Ralston
13
,
Danielle Swaney
4, 5, 8, 9
,
Adolfo García-Sastre
11, 12, 15, 16
,
Melanie Ott
8, 9, 10
,
Marco Vignuzzi
6
,
Peter Walter
1, 2
,
Aashish Manglik
3, 4, 8, 17
,
Caleigh M. Azumaya
,
Cristina Puchades
,
Ming Sun
,
Julian R Braxton
,
Axel F Brilot
,
Fei Li
,
Kyle E Lopez
,
Arthur Melo
,
Frank Moss
,
Joana Paulino
,
Thomas H Pospiech
,
Sergei Pourmal
,
Alexandrea N Rizo
,
Paul V. Thomas
,
Feng Wang
,
Zanlin Yu
,
Miles Sasha Dickinson
,
Henry C Nguyen
,
Daniel Asarnow
,
Melody G Campbell
,
Cynthia M. Chio
,
Un Seng Chio
,
Devan Diwanji
,
Bryan Faust
,
Meghna Gupta
,
Mingliang Jin
,
Junrui Li
,
Yanxin Liu
,
Gregory E Merz
,
Smriti Sangwan
,
Tsz Kin Martin Tsui
,
Raphael Trenker
,
Donovan Trinidad
,
Eric Tse
,
Kaihua Zhang
,
Fengbo Zhou
,
Nadia Herrera
,
Huong T Kratochvil
,
Ursula Schulze-Gahmen
,
Michael C. Thompson
,
Iris D. Young
,
Justin Biel
,
Ishan Deshpande
,
Xi Liu
,
Christian Bache Billesbølle
,
Carlos Nowotny
,
Amber M. Smith
,
Jianhua Zhao
,
Alisa Bowen
,
Nick Hoppe
,
Yen-Li Li
,
Phuong Nguyen
,
Mali Safari
,
Kaitlin Schaefer
,
Natalie Whitis
,
Michelle Moritz
,
Tristan W Owens
,
Amy Diallo
,
Kate Kim
,
Jessica K Peters
,
Erron W Titus
,
Jenny Chen
,
Loan Doan
,
Sebastian Flores
,
Victor L Lam
,
Yang Li
,
Megan Lo
,
Aye C Thwin
,
Stephanie Wankowicz
,
Yang Zhang
,
David Bulkley
,
Arceli Joves
,
Almarie Joves
,
Liam Mckay
,
Mariano Tabios
,
Oren S Rosenberg
,
Kliment A. Verba
,
David A. Agard
,
Yifan Cheng
,
James S. Fraser
,
Adam Frost
,
Natalia Jura
,
Tanja Kortemme
,
Nevan J. Krogan
,
Aashish Manglik
,
Daniel R Southworth
,
Robert M. Stroud
1
14
Cytiva Life Sciences, Marlborough, MA, USA.
|
Publication type: Journal Article
Publication date: 2020-12-18
Multidisciplinary
Abstract
Nanobodies that neutralize
Monoclonal antibodies that bind to the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) show therapeutic promise but must be produced in mammalian cells and need to be delivered intravenously. By contrast, single-domain antibodies called nanobodies can be produced in bacteria or yeast, and their stability may enable aerosol delivery. Two papers now report nanobodies that bind tightly to spike and efficiently neutralize SARS-CoV-2 in cells. Schoof et al. screened a yeast surface display of synthetic nanobodies and Xiang et al. screened anti-spike nanobodies produced by a llama. Both groups identified highly potent nanobodies that lock the spike protein in an inactive conformation. Multivalent constructs of selected nanobodies achieved even more potent neutralization.
Science
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Schoof M. et al. An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike // Science. 2020. Vol. 370. No. 6523. pp. 1473-1479.
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Schoof M. et al. An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike // Science. 2020. Vol. 370. No. 6523. pp. 1473-1479.
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TY - JOUR
DO - 10.1126/science.abe3255
UR - https://doi.org/10.1126/science.abe3255
TI - An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike
T2 - Science
AU - Schoof, Michael
AU - Faust, Bryan
AU - Saunders, Reuben A
AU - Sangwan, Smriti
AU - Rezelj, Veronica V
AU - Hoppe, Nick
AU - Boone, Morgane
AU - Billesbølle, Christian B
AU - Puchades, Cristina
AU - Azumaya, C. M.
AU - Kratochvil, H.
AU - Zimanyi, Marcell
AU - Deshpande, Ishan
AU - Liang, Jiahao
AU - Dickinson, Miles Sasha
AU - Nguyen, Kim Cuong
AU - Chio, Cynthia M
AU - Merz, Gregory E
AU - Thompson, Michael C.
AU - Diwanji, Devan
AU - Schaefer, Kaitlin
AU - Anand, Aditya A
AU - Dobzinski, Niv
AU - S. Zha, Beth
AU - Simoneau, Camille R.
AU - Leon, Kristoffer E
AU - White, Kris M
AU - Chio, Un Seng
AU - Gupta, Meghna
AU - Jin, M
AU - Li, Fei
AU - Liu, Yanxin
AU - Zhang, Kaihua
AU - Bulkley, David
AU - Sun, Ming
AU - Smith, Joel M
AU - Rizo, Alexandrea
AU - Moss, Frank R
AU - Brilot, Axel F.
AU - Pourmal, Sergei
AU - Trenker, R
AU - Pospiech, Thomas H
AU - Gupta, Sayan
AU - Barsi Rhyne, Benjamin
AU - Belyy, Vladislav
AU - Barile Hill, Andrew W
AU - Nock, Silke
AU - LIU, YUWEI
AU - Krogan, Nevan J.
AU - Ralston, Corie Y.
AU - Swaney, Danielle
AU - García-Sastre, Adolfo
AU - Ott, Melanie
AU - Vignuzzi, Marco
AU - Walter, Peter
AU - Manglik, Aashish
AU - Azumaya, Caleigh M.
AU - Puchades, Cristina
AU - Sun, Ming
AU - Braxton, Julian R
AU - Brilot, Axel F
AU - Gupta, Meghna
AU - Li, Fei
AU - Lopez, Kyle E
AU - Melo, Arthur
AU - Merz, Gregory E
AU - Moss, Frank
AU - Paulino, Joana
AU - Pospiech, Thomas H
AU - Pourmal, Sergei
AU - Rizo, Alexandrea N
AU - Smith, Amber M.
AU - Thomas, Paul V.
AU - Wang, Feng
AU - Yu, Zanlin
AU - Dickinson, Miles Sasha
AU - Nguyen, Henry C
AU - Asarnow, Daniel
AU - Campbell, Melody G
AU - Chio, Cynthia M.
AU - Chio, Un Seng
AU - Diwanji, Devan
AU - Faust, Bryan
AU - Hoppe, Nick
AU - Jin, Mingliang
AU - Li, Junrui
AU - Liu, Yanxin
AU - Sangwan, Smriti
AU - Tsui, Tsz Kin Martin
AU - Trenker, Raphael
AU - Trinidad, Donovan
AU - Tse, Eric
AU - Zhang, Kaihua
AU - Zhou, Fengbo
AU - Herrera, Nadia
AU - Kratochvil, Huong T
AU - Schulze-Gahmen, Ursula
AU - Thompson, Michael C.
AU - Young, Iris D.
AU - Biel, Justin
AU - Deshpande, Ishan
AU - Liu, Xi
AU - Billesbølle, Christian Bache
AU - Nowotny, Carlos
AU - Zhao, Jianhua
AU - Bowen, Alisa
AU - Li, Yen-Li
AU - Nguyen, Phuong
AU - Safari, Mali
AU - Schaefer, Kaitlin
AU - Whitis, Natalie
AU - Moritz, Michelle
AU - Owens, Tristan W
AU - Diallo, Amy
AU - Kim, Kate
AU - Peters, Jessica K
AU - Titus, Erron W
AU - Chen, Jenny
AU - Doan, Loan
AU - Flores, Sebastian
AU - Lam, Victor L
AU - Li, Yang
AU - Lo, Megan
AU - Thwin, Aye C
AU - Wankowicz, Stephanie
AU - Zhang, Yang
AU - Bulkley, David
AU - Joves, Arceli
AU - Joves, Almarie
AU - Mckay, Liam
AU - Tabios, Mariano
AU - Rosenberg, Oren S
AU - Verba, Kliment A.
AU - Agard, David A.
AU - Cheng, Yifan
AU - Fraser, James S.
AU - Frost, Adam
AU - Jura, Natalia
AU - Kortemme, Tanja
AU - Krogan, Nevan J.
AU - Manglik, Aashish
AU - Southworth, Daniel R
AU - Stroud, Robert M.
PY - 2020
DA - 2020/12/18 00:00:00
PB - American Association for the Advancement of Science (AAAS)
SP - 1473-1479
IS - 6523
VL - 370
SN - 0036-8075
SN - 1095-9203
ER -
Cite this
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@article{2020_Schoof,
author = {Michael Schoof and Bryan Faust and Reuben A Saunders and Smriti Sangwan and Veronica V Rezelj and Nick Hoppe and Morgane Boone and Christian B Billesbølle and Cristina Puchades and C. M. Azumaya and H. Kratochvil and Marcell Zimanyi and Ishan Deshpande and Jiahao Liang and Miles Sasha Dickinson and Kim Cuong Nguyen and Cynthia M Chio and Gregory E Merz and Michael C. Thompson and Devan Diwanji and Kaitlin Schaefer and Aditya A Anand and Niv Dobzinski and Beth S. Zha and Camille R. Simoneau and Kristoffer E Leon and Kris M White and Un Seng Chio and Meghna Gupta and M Jin and Fei Li and Yanxin Liu and Kaihua Zhang and David Bulkley and Ming Sun and Joel M Smith and Alexandrea Rizo and Frank R Moss and Axel F. Brilot and Sergei Pourmal and R Trenker and Thomas H Pospiech and Sayan Gupta and Benjamin Barsi Rhyne and Vladislav Belyy and Andrew W Barile Hill and Silke Nock and YUWEI LIU and Nevan J. Krogan and Corie Y. Ralston and Danielle Swaney and Adolfo García-Sastre and Melanie Ott and Marco Vignuzzi and Peter Walter and Aashish Manglik and Caleigh M. Azumaya and Cristina Puchades and Ming Sun and Julian R Braxton and Axel F Brilot and Meghna Gupta and Fei Li and Kyle E Lopez and Arthur Melo and Gregory E Merz and Frank Moss and Joana Paulino and Thomas H Pospiech and Sergei Pourmal and Alexandrea N Rizo and Amber M. Smith and Paul V. Thomas and Feng Wang and Zanlin Yu and Miles Sasha Dickinson and Henry C Nguyen and Daniel Asarnow and Melody G Campbell and Cynthia M. Chio and Un Seng Chio and Devan Diwanji and Bryan Faust and Nick Hoppe and Mingliang Jin and Junrui Li and Yanxin Liu and Smriti Sangwan and Tsz Kin Martin Tsui and Raphael Trenker and Donovan Trinidad and Eric Tse and Kaihua Zhang and Fengbo Zhou and Nadia Herrera and Huong T Kratochvil and Ursula Schulze-Gahmen and Michael C. Thompson and Iris D. Young and Justin Biel and Ishan Deshpande and Xi Liu and Christian Bache Billesbølle and Carlos Nowotny and Jianhua Zhao and Alisa Bowen and Yen-Li Li and Phuong Nguyen and Mali Safari and Kaitlin Schaefer and Natalie Whitis and Michelle Moritz and Tristan W Owens and Amy Diallo and Kate Kim and Jessica K Peters and Erron W Titus and Jenny Chen and Loan Doan and Sebastian Flores and Victor L Lam and Yang Li and Megan Lo and Aye C Thwin and Stephanie Wankowicz and Yang Zhang and David Bulkley and Arceli Joves and Almarie Joves and Liam Mckay and Mariano Tabios and Oren S Rosenberg and Kliment A. Verba and David A. Agard and Yifan Cheng and James S. Fraser and Adam Frost and Natalia Jura and Tanja Kortemme and Nevan J. Krogan and Aashish Manglik and Daniel R Southworth and Robert M. Stroud},
title = {An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike},
journal = {Science},
year = {2020},
volume = {370},
publisher = {American Association for the Advancement of Science (AAAS)},
month = {dec},
url = {https://doi.org/10.1126/science.abe3255},
number = {6523},
pages = {1473--1479},
doi = {10.1126/science.abe3255}
}
Cite this
MLA
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Schoof, Michael, et al. “An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.” Science, vol. 370, no. 6523, Dec. 2020, pp. 1473-1479. https://doi.org/10.1126/science.abe3255.