Open Access

Science

, volume 384 , issue 6694 , pages 428-437

Vitamin D regulates microbiome-dependent cancer immunity

Evangelos Giampazolias ^{1, 2}

Mariana Pereira Da Costa ¹

Khiem C Lam ³

Kok Haw Jonathan Lim ^{1, 4}

Ana Cardoso ¹

Cécile Piot ¹

Probir Chakravarty ⁵

Sonja Blasche ⁶

Swara Patel ²

Adi Biram ¹

Tomas Castro Dopico ¹

Michael D. Buck ¹

Richard Rosario Rodrigues ^{7, 8}

Gry Poulsen ⁹

Susana A Palma Duran ¹⁰

Neil Rogers ¹

Maria A Koufaki ¹¹

Carlos M Minutti ¹

Pengbo Wang ²

Alexander Vdovin ²

Bruno Frederico ¹

Eleanor Childs ¹

Sonia Lee ¹

Ben Simpson ¹²

Andrea Iseppon ¹³

Sara Omenetti ¹³

Gavin Kelly ⁵

Robert Goldstone ⁵

Emma L. Nye ¹⁴

Alejandro Suárez Bonnet ^{14, 15}

Simon L Priestnall ^{14, 15}

James I. MacRae ¹⁰

Santiago Zelenay ¹¹

K. Patil ⁶

Kevin Litchfield ¹²

James C. Lee ^{16, 17}

Tine Jess ⁹

Romina S. Goldszmid ³

Caetano Reis e Sousa ¹

Hide authors affiliations Show authors affiliations: 17 affiliations

Immunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, UK. |

Cancer Immunosurveillance Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4BX, UK.

University of Manchester

Cancer Research UK Manchester Institute

Inflammatory Cell Dynamics Section, Laboratory of Integrative Cancer Immunology (LICI), Center for Cancer Research (CCR), National Cancer Institute (NCI), Bethesda, MD 20892, USA. |

⁴

Department of Immunology and Inflammation, Imperial College London, London SW7 2AZ, UK. |

⁵

Bioinformatics and Biostatistics STP, The Francis Crick Institute, London NW1 1AT, UK. |

⁶

MRC Toxicology Unit, University of Cambridge, Cambridge CB2 1QR, UK. |

⁷

Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA. |

⁸

Microbiome and Genetics Core, LICI, CCR, NCI, Bethesda, MD 20892, USA. |

⁹

National Center of Excellence for Molecular Prediction of Inflammatory Bowel Disease, PREDICT, Faculty of Medicine, Aalborg University, Department of Gastroenterology and Hepatology, Aalborg University Hospital, A DK-2450 Copenhagen, Denmark.

Aalborg University Hospital

Copenhagen University Hospital

¹⁰

Metabolomics STP, The Francis Crick Institute, London NW1 1AT, UK. |

¹¹

Cancer Inflammation and Immunity Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4BX, UK.

University of Manchester

Cancer Research UK Manchester Institute

¹²

Tumor Immunogenomics and Immunosurveillance (TIGI) Lab, UCL Cancer Institute, London WC1E 6DD, UK. |

¹³

AhRimmunity Laboratory, The Francis Crick Institute, London NW1 1AT, UK. |

¹⁴

Experimental Histopathology, The Francis Crick Institute, London NW1 1AT, UK. |

¹⁵

Department of Pathobiology and Population Sciences, The Royal Veterinary College, North Mimms, Hatfield, Hertfordshire AL9 7TA, UK. |

¹⁶

Genetic Mechanisms of Disease Laboratory, The Francis Crick Institute, London NW1 1AT, UK. |

¹⁷

Institute of Liver and Digestive Health, Division of Medicine, Royal Free Hospital, University College London, London NW3 2QG, UK. |

Publication type: Journal Article

Publication date: 2024-04-26

American Association for the Advancement of Science (AAAS)

Science

scimago Q1

wos Q1

SJR: 10.416

CiteScore: 48.4

Impact factor: 45.8

ISSN: 00368075, 10959203

DOI: 10.1126/science.adh7954

Copy DOI

PubMed ID: 38662827

Abstract

A role for vitamin D in immune modulation and in cancer has been suggested. In this work, we report that mice with increased availability of vitamin D display greater immune-dependent resistance to transplantable cancers and augmented responses to checkpoint blockade immunotherapies. Similarly, in humans, vitamin D–induced genes correlate with improved responses to immune checkpoint inhibitor treatment as well as with immunity to cancer and increased overall survival. In mice, resistance is attributable to the activity of vitamin D on intestinal epithelial cells, which alters microbiome composition in favor of Bacteroides fragilis , which positively regulates cancer immunity. Our findings indicate a previously unappreciated connection between vitamin D, microbial commensal communities, and immune responses to cancer. Collectively, they highlight vitamin D levels as a potential determinant of cancer immunity and immunotherapy success.

Found

1 citation

Tippairote Torsak

27 publications, 491 citations, 1 review

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GOST Copy

Giampazolias E. et al. Vitamin D regulates microbiome-dependent cancer immunity // Science. 2024. Vol. 384. No. 6694. pp. 428-437.

GOST all authors (up to 50) Copy

Giampazolias E., Da Costa M. P., Lam K. C., Lim K. H. J., Cardoso A., Piot C., Chakravarty P., Blasche S., Patel S., Biram A., Castro Dopico T., Buck M. D., Rodrigues R. R., Poulsen G., Palma Duran S. A., Rogers N., Koufaki M. A., Minutti C. M., Wang P., Vdovin A., Frederico B., Childs E., Lee S., Simpson B., Iseppon A., Omenetti S., Kelly G., Goldstone R., Nye E. L., Suárez Bonnet A., Priestnall S. L., MacRae J. I., Zelenay S., Patil K., Litchfield K., Lee J. C., Jess T., Goldszmid R. S., Reis e Sousa C. Vitamin D regulates microbiome-dependent cancer immunity // Science. 2024. Vol. 384. No. 6694. pp. 428-437.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1126/science.adh7954

UR - https://www.science.org/doi/10.1126/science.adh7954

TI - Vitamin D regulates microbiome-dependent cancer immunity

T2 - Science

AU - Giampazolias, Evangelos

AU - Da Costa, Mariana Pereira

AU - Lam, Khiem C

AU - Lim, Kok Haw Jonathan

AU - Cardoso, Ana

AU - Piot, Cécile

AU - Chakravarty, Probir

AU - Blasche, Sonja

AU - Patel, Swara

AU - Biram, Adi

AU - Castro Dopico, Tomas

AU - Buck, Michael D.

AU - Rodrigues, Richard Rosario

AU - Poulsen, Gry

AU - Palma Duran, Susana A

AU - Rogers, Neil

AU - Koufaki, Maria A

AU - Minutti, Carlos M

AU - Wang, Pengbo

AU - Vdovin, Alexander

AU - Frederico, Bruno

AU - Childs, Eleanor

AU - Lee, Sonia

AU - Simpson, Ben

AU - Iseppon, Andrea

AU - Omenetti, Sara

AU - Kelly, Gavin

AU - Goldstone, Robert

AU - Nye, Emma L.

AU - Suárez Bonnet, Alejandro

AU - Priestnall, Simon L

AU - MacRae, James I.

AU - Zelenay, Santiago

AU - Patil, K.

AU - Litchfield, Kevin

AU - Lee, James C.

AU - Jess, Tine

AU - Goldszmid, Romina S.

AU - Reis e Sousa, Caetano

PY - 2024

DA - 2024/04/26

PB - American Association for the Advancement of Science (AAAS)

SP - 428-437

IS - 6694

VL - 384

PMID - 38662827

SN - 0036-8075

SN - 1095-9203

ER -

BibTex |

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BibTex (up to 50 authors) Copy

@article{2024_Giampazolias,

author = {Evangelos Giampazolias and Mariana Pereira Da Costa and Khiem C Lam and Kok Haw Jonathan Lim and Ana Cardoso and Cécile Piot and Probir Chakravarty and Sonja Blasche and Swara Patel and Adi Biram and Tomas Castro Dopico and Michael D. Buck and Richard Rosario Rodrigues and Gry Poulsen and Susana A Palma Duran and Neil Rogers and Maria A Koufaki and Carlos M Minutti and Pengbo Wang and Alexander Vdovin and Bruno Frederico and Eleanor Childs and Sonia Lee and Ben Simpson and Andrea Iseppon and Sara Omenetti and Gavin Kelly and Robert Goldstone and Emma L. Nye and Alejandro Suárez Bonnet and Simon L Priestnall and James I. MacRae and Santiago Zelenay and K. Patil and Kevin Litchfield and James C. Lee and Tine Jess and Romina S. Goldszmid and Caetano Reis e Sousa},

title = {Vitamin D regulates microbiome-dependent cancer immunity},

journal = {Science},

year = {2024},

volume = {384},

publisher = {American Association for the Advancement of Science (AAAS)},

month = {apr},

url = {https://www.science.org/doi/10.1126/science.adh7954},

number = {6694},

pages = {428--437},

doi = {10.1126/science.adh7954}

}

MLA

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MLA Copy

Giampazolias, Evangelos, et al. “Vitamin D regulates microbiome-dependent cancer immunity.” Science, vol. 384, no. 6694, Apr. 2024, pp. 428-437. https://www.science.org/doi/10.1126/science.adh7954.

Publisher

American Association for the Advancement of Science (AAAS)

Journal

Science

scimago Q1

wos Q1

SJR

10.416

CiteScore

48.4

Impact factor

45.8

ISSN

00368075 (Print)

10959203 (Electronic)

Profiles

Kiran R Patil