American Association for the Advancement of Science (AAAS)

Science Translational Medicine

, volume 4 , issue 150

Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium tuberculosis

João Neres ^{1, 2, 3}

Florence Pojer ^{1, 2}

Elisabetta Molteni ^{1, 4}

Laurent R Chiarelli ^{1, 4}

Neeraj Dhar ^{1, 2}

Stefanie Boy Röttger ^{1, 2}

Silvia Buroni ^{1, 4}

Elizabeth Fullam ^{1, 2}

Giulia Degiacomi ^{1, 4}

Anna Paola Lucarelli ⁴

Randy J. Read ⁵

Giuseppe Zanoni ⁶

Dale E Edmondson ⁷

Edda De Rossi ^{1, 4}

Maria Rosalia Pasca ^{1, 4}

John D. McKinney ^{1, 2}

Paul J Dyson ³

Giovanna Riccardi ^{1, 4}

Andrea Mattevi ⁴

Stewart T Cole ^{1, 2}

Claudia Binda ^{1, 4}

Hide authors affiliations Show authors affiliations: 7 affiliations

More Medicines for Tuberculosis (MM4TB) Consortium.

Global Health Institute, École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland. |

Institute of Chemical Sciences and Engineering, École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland. |

⁴

Department of Biology and Biotechnology, University of Pavia, Via Ferrata 9, 27100 Pavia, Italy. |

⁵

Department of Haematology, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 0XY, UK. |

⁶

Department of Chemistry, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy. |

⁷

Department of Biochemistry, Emory University, Atlanta, GA 30322, USA. |

Publication type: Journal Article

Publication date: 2012-09-05

American Association for the Advancement of Science (AAAS)

Science Translational Medicine

scimago Q1

wos Q1

SJR: 6.722

CiteScore: 27.9

Impact factor: 14.6

ISSN: 19466234, 19466242

DOI: 10.1126/scitranslmed.3004395

Copy DOI

PubMed ID: 22956199

General Medicine

Abstract

The crystal structure of the mycobacterial DprE1 reveals how the TB drug benzothiazinone BTZ043 blocks this microbial enzyme target.

Found

13 citations

Makarov Vadim

🥼 🤝

DSc in Chemistry

177 publications, 4 618 citations, 5 reviews

h-index: 36

Federal Research Centre “Fundamentals of Biotechnology” of the Russian Academy of Sciences

Research interests

Early drug discovery

Medicinal Chemistry

1 citation

Krasnykh Olga

PhD in Chemistry

49 publications, 503 citations

h-index: 10

Perm National Research Polytechnic University

Research interests

Drug design

Synthetic Organic Chemistry

1 citation

Triandafilova Galina

23 publications, 174 citations

h-index: 9

Perm National Research Polytechnic University

Institute of Ecology and Genetics of Microorganisms of the Ural Branch of the Russian Academy of Sciences

Research interests

Antioxidants

Microbiology

1 citation

Egorova Anna

PhD

22 publications, 270 citations, 23 reviews

h-index: 8

Federal Research Centre “Fundamentals of Biotechnology” of the Russian Academy of Sciences

Research interests

Medicinal Chemistry

1 citation

Harris Lawrence

36 publications, 435 citations

h-index: 11

1 citation

Shchegolkov Evgeny

70 publications, 927 citations, 57 reviews

h-index: 16

Postovsky Institute of Organic Synthesis of the Ural Branch of the Russian Academy of Sciences

Research interests

Organic synthesis

Top-30

Journals

	2 4 6 8 10 12 14 16
European Journal of Medicinal Chemistry	European Journal of Medicinal Chemistry, 16, 8.99% European Journal of Medicinal Chemistry 16 publications, 8.99%
Journal of Medicinal Chemistry	Journal of Medicinal Chemistry, 13, 7.3% Journal of Medicinal Chemistry 13 publications, 7.3%
Antimicrobial Agents and Chemotherapy	Antimicrobial Agents and Chemotherapy, 9, 5.06% Antimicrobial Agents and Chemotherapy 9 publications, 5.06%
ACS Medicinal Chemistry Letters	ACS Medicinal Chemistry Letters, 7, 3.93% ACS Medicinal Chemistry Letters 7 publications, 3.93%
ChemMedChem	ChemMedChem, 5, 2.81% ChemMedChem 5 publications, 2.81%
Drug Discovery Today	Drug Discovery Today, 4, 2.25% Drug Discovery Today 4 publications, 2.25%
ACS Infectious Diseases	ACS Infectious Diseases, 4, 2.25% ACS Infectious Diseases 4 publications, 2.25%
ACS Chemical Biology	ACS Chemical Biology, 4, 2.25% ACS Chemical Biology 4 publications, 2.25%
Medicinal Chemistry Research	Medicinal Chemistry Research, 3, 1.69% Medicinal Chemistry Research 3 publications, 1.69%
Journal of Antibiotics	Journal of Antibiotics, 3, 1.69% Journal of Antibiotics 3 publications, 1.69%
Bioorganic and Medicinal Chemistry	Bioorganic and Medicinal Chemistry, 3, 1.69% Bioorganic and Medicinal Chemistry 3 publications, 1.69%
Tuberculosis	Tuberculosis, 3, 1.69% Tuberculosis 3 publications, 1.69%
Angewandte Chemie	Angewandte Chemie, 3, 1.69% Angewandte Chemie 3 publications, 1.69%
Angewandte Chemie - International Edition	Angewandte Chemie - International Edition, 3, 1.69% Angewandte Chemie - International Edition 3 publications, 1.69%
Microbiology spectrum	Microbiology spectrum, 3, 1.69% Microbiology spectrum 3 publications, 1.69%
RSC Advances	RSC Advances, 3, 1.69% RSC Advances 3 publications, 1.69%
Journal of Biomolecular Structure and Dynamics	Journal of Biomolecular Structure and Dynamics, 3, 1.69% Journal of Biomolecular Structure and Dynamics 3 publications, 1.69%
Microbiology	Microbiology, 2, 1.12% Microbiology 2 publications, 1.12%
Applied Sciences (Switzerland)	Applied Sciences (Switzerland), 2, 1.12% Applied Sciences (Switzerland) 2 publications, 1.12%
Nature Communications	Nature Communications, 2, 1.12% Nature Communications 2 publications, 1.12%
Chemical Communications	Chemical Communications, 2, 1.12% Chemical Communications 2 publications, 1.12%
PLoS ONE	PLoS ONE, 2, 1.12% PLoS ONE 2 publications, 1.12%
Bioorganic and Medicinal Chemistry Letters	Bioorganic and Medicinal Chemistry Letters, 2, 1.12% Bioorganic and Medicinal Chemistry Letters 2 publications, 1.12%
ChemistrySelect	ChemistrySelect, 2, 1.12% ChemistrySelect 2 publications, 1.12%
Journal of the American Chemical Society	Journal of the American Chemical Society, 2, 1.12% Journal of the American Chemical Society 2 publications, 1.12%
Chemistry and Biodiversity	Chemistry and Biodiversity, 2, 1.12% Chemistry and Biodiversity 2 publications, 1.12%
EMBO Molecular Medicine	EMBO Molecular Medicine, 2, 1.12% EMBO Molecular Medicine 2 publications, 1.12%
Pharmaceuticals	Pharmaceuticals, 2, 1.12% Pharmaceuticals 2 publications, 1.12%
Russian Journal of Bioorganic Chemistry	Russian Journal of Bioorganic Chemistry, 2, 1.12% Russian Journal of Bioorganic Chemistry 2 publications, 1.12%
	2 4 6 8 10 12 14 16

Publishers

	5 10 15 20 25 30 35 40 45
Elsevier	Elsevier, 41, 23.03% Elsevier 41 publications, 23.03%
American Chemical Society (ACS)	American Chemical Society (ACS), 33, 18.54% American Chemical Society (ACS) 33 publications, 18.54%
Springer Nature	Springer Nature, 24, 13.48% Springer Nature 24 publications, 13.48%
Wiley	Wiley, 23, 12.92% Wiley 23 publications, 12.92%
American Society for Microbiology	American Society for Microbiology, 14, 7.87% American Society for Microbiology 14 publications, 7.87%
Taylor & Francis	Taylor & Francis, 7, 3.93% Taylor & Francis 7 publications, 3.93%
MDPI	MDPI, 7, 3.93% MDPI 7 publications, 3.93%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 7, 3.93% Royal Society of Chemistry (RSC) 7 publications, 3.93%
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 4, 2.25% Cold Spring Harbor Laboratory 4 publications, 2.25%
Bentham Science Publishers Ltd.	Bentham Science Publishers Ltd., 3, 1.69% Bentham Science Publishers Ltd. 3 publications, 1.69%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 3, 1.69% Public Library of Science (PLoS) 3 publications, 1.69%
Microbiology Society	Microbiology Society, 2, 1.12% Microbiology Society 2 publications, 1.12%
Pleiades Publishing	Pleiades Publishing, 2, 1.12% Pleiades Publishing 2 publications, 1.12%
International Union of Crystallography (IUCr)	International Union of Crystallography (IUCr), 1, 0.56% International Union of Crystallography (IUCr) 1 publication, 0.56%
American Society for Biochemistry and Molecular Biology	American Society for Biochemistry and Molecular Biology, 1, 0.56% American Society for Biochemistry and Molecular Biology 1 publication, 0.56%
European Molecular Biology Organization	European Molecular Biology Organization, 1, 0.56% European Molecular Biology Organization 1 publication, 0.56%
Oxford University Press	Oxford University Press, 1, 0.56% Oxford University Press 1 publication, 0.56%
American Association for the Advancement of Science (AAAS)	American Association for the Advancement of Science (AAAS), 1, 0.56% American Association for the Advancement of Science (AAAS) 1 publication, 0.56%
Consilium Medicum	Consilium Medicum, 1, 0.56% Consilium Medicum 1 publication, 0.56%
	5 10 15 20 25 30 35 40 45

We do not take into account publications without a DOI.
Statistics recalculated weekly.

Are you a researcher?

Create a profile to get free access to personal recommendations for colleagues and new articles.

Metrics

178

Cite this

GOST |

Cite this

GOST Copy

Neres J. et al. Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium tuberculosis // Science Translational Medicine. 2012. Vol. 4. No. 150.

GOST all authors (up to 50) Copy

Neres J., Pojer F., Molteni E., Chiarelli L. R., Dhar N., Boy Röttger S., Buroni S., Fullam E., Degiacomi G., Lucarelli A. P., Read R. J., Zanoni G., Edmondson D. E., De Rossi E., Pasca M. R., McKinney J. D., Dyson P. J., Riccardi G., Mattevi A., Cole S. T., Binda C. Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium tuberculosis // Science Translational Medicine. 2012. Vol. 4. No. 150.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1126/scitranslmed.3004395

UR - https://doi.org/10.1126/scitranslmed.3004395

TI - Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium tuberculosis

T2 - Science Translational Medicine

AU - Neres, João

AU - Pojer, Florence

AU - Molteni, Elisabetta

AU - Chiarelli, Laurent R

AU - Dhar, Neeraj

AU - Boy Röttger, Stefanie

AU - Buroni, Silvia

AU - Fullam, Elizabeth

AU - Degiacomi, Giulia

AU - Lucarelli, Anna Paola

AU - Read, Randy J.

AU - Zanoni, Giuseppe

AU - Edmondson, Dale E

AU - De Rossi, Edda

AU - Pasca, Maria Rosalia

AU - McKinney, John D.

AU - Dyson, Paul J

AU - Riccardi, Giovanna

AU - Mattevi, Andrea

AU - Cole, Stewart T

AU - Binda, Claudia

PY - 2012

DA - 2012/09/05

PB - American Association for the Advancement of Science (AAAS)

IS - 150

VL - 4

PMID - 22956199

SN - 1946-6234

SN - 1946-6242

ER -

BibTex

Cite this

BibTex (up to 50 authors) Copy

@article{2012_Neres,

author = {João Neres and Florence Pojer and Elisabetta Molteni and Laurent R Chiarelli and Neeraj Dhar and Stefanie Boy Röttger and Silvia Buroni and Elizabeth Fullam and Giulia Degiacomi and Anna Paola Lucarelli and Randy J. Read and Giuseppe Zanoni and Dale E Edmondson and Edda De Rossi and Maria Rosalia Pasca and John D. McKinney and Paul J Dyson and Giovanna Riccardi and Andrea Mattevi and Stewart T Cole and Claudia Binda},

title = {Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium tuberculosis},

journal = {Science Translational Medicine},

year = {2012},

volume = {4},

publisher = {American Association for the Advancement of Science (AAAS)},

month = {sep},

url = {https://doi.org/10.1126/scitranslmed.3004395},

number = {150},

doi = {10.1126/scitranslmed.3004395}

}

Publisher

American Association for the Advancement of Science (AAAS)

Journal

Science Translational Medicine

scimago Q1

wos Q1

SJR

6.722

CiteScore

27.9

Impact factor

14.6

ISSN

19466234 (Print)

19466242 (Electronic)