Open Access

Science, volume 369, issue 6506, pages 1010-1014

Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail

Johanna Hansen ¹

Alina Baum ¹

Kristen E Pascal ¹

Vincenzo Russo ¹

Stephanie Giordano ¹

Elzbieta Wloga ¹

Benjamin O Fulton ¹

Ying Yan ¹

Katrina Koon ¹

Krunal Patel ¹

Kyung Min Chung ¹

Aynur Hermann ¹

Erica Ullman ¹

Jonathan Cruz ¹

Ashique Rafique ¹

Tammy Huang ¹

JEANETTE L. FAIRHURST ¹

Christen Libertiny ¹

Marine Malbec ¹

Wen Yi Lee ¹

Richard Welsh ¹

Glen Farr ¹

Seth Pennington ¹

Dipali Deshpande ¹

Jemmie Cheng ¹

Anke Watty ¹

Pascal Bouffard ¹

Robert BABB ¹

Natasha Levenkova ¹

Calvin Chen ¹

Bojie Zhang ¹

Annabel Romero Hernandez ¹

Kei Saotome ¹

Yi Zhou ¹

Matthew Franklin ¹

Sumathi Sivapalasingam ¹

David Chien Lye ²

Stuart Weston ³

James Logue ³

Robert Haupt ³

Matthew Frieman ³

Gang Chen ¹

William H. Olson ¹

Andrew J. Murphy ¹

Neil Stahl ¹

George D. Yancopoulos ¹

Christos A. Kyratsous ¹

Hide authors affiliations Show authors affiliations: 3 affiliations

Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA. |

National Centre for Infectious Diseases, Tan Tock Seng Hospital, Yong Loo Lin School of Medicine, Lee Kong Chian School of Medicine, 16 Jalan Tan Tock Seng, Singapore 308442, Singapore. |

Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. |

Publication type: Journal Article

Publication date: 2020-08-21

American Association for the Advancement of Science (AAAS)

Journal: Science

Quartile SCImago

Quartile WOS

Impact factor: 56.9

ISSN: 00368075, 10959203

DOI: 10.1126/science.abd0827

Copy DOI

PubMed ID: 32540901

Multidisciplinary

Abstract

An antibody cocktail against SARS-CoV-2 There is an urgent focus on antibodies that target the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral spike and prevent the virus from entering host cells. Hansen et al. generated a large panel of antibodies against the spike protein from humanized mice and recovered patients. From this panel, they identified several neutralizing antibodies, including pairs that do not compete for binding to the receptor binding domain. Baum et al. focused in on four of these antibodies. All four are effective against known spike variants. However, by growing a pseudovirus that expresses the spike in the presence of individual antibodies, the authors were able to select for spike mutants resistant to that antibody. In contrast, escape mutants are not selected when pseudovirus is grown in the presence of pairs of antibodies that either do not compete or only partially compete for binding to the RBD. Such a pair might be used in a therapeutic antibody cocktail. Science, this issue p. 1010, p. 1014 A noncompeting antibody cocktail to SARS-CoV-2 spike protein safeguards against the ability of virus mutations to lead to antibody resistance. Neutralizing antibodies have become an important tool in treating infectious diseases. Recently, two separate approaches yielded successful antibody treatments for Ebola—one from genetically humanized mice and the other from a human survivor. Here, we describe parallel efforts using both humanized mice and convalescent patients to generate antibodies against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein, which yielded a large collection of fully human antibodies that were characterized for binding, neutralization, and three-dimensional structure. On the basis of these criteria, we selected pairs of highly potent individual antibodies that simultaneously bind the receptor binding domain of the spike protein, thereby providing ideal partners for a therapeutic antibody cocktail that aims to decrease the potential for virus escape mutants that might arise in response to selective pressure from a single-antibody treatment.

By date By citations

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Citations by journals

	5 10 15 20 25 30 35
Cell Reports	Cell Reports, 34, 3.05% Cell Reports 34 publications, 3.05%
Nature Communications	Nature Communications, 34, 3.05% Nature Communications 34 publications, 3.05%
Frontiers in Immunology	Frontiers in Immunology, 28, 2.52% Frontiers in Immunology 28 publications, 2.52%
Viruses	Viruses, 24, 2.16% Viruses 24 publications, 2.16%
Cell	Cell, 22, 1.98% Cell 22 publications, 1.98%
Science	Science, 20, 1.8% Science 20 publications, 1.8%
Nature	Nature, 20, 1.8% Nature 20 publications, 1.8%
iScience	iScience, 15, 1.35% iScience 15 publications, 1.35%
Cell Host and Microbe	Cell Host and Microbe, 12, 1.08% Cell Host and Microbe 12 publications, 1.08%
PLoS Pathogens	PLoS Pathogens, 11, 0.99% PLoS Pathogens 11 publications, 0.99%
Immunity	Immunity, 11, 0.99% Immunity 11 publications, 0.99%
Vaccines	Vaccines, 11, 0.99% Vaccines 11 publications, 0.99%
Cell Discovery	Cell Discovery, 11, 0.99% Cell Discovery 11 publications, 0.99%
Signal Transduction and Targeted Therapy	Signal Transduction and Targeted Therapy, 10, 0.9% Signal Transduction and Targeted Therapy 10 publications, 0.9%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 9, 0.81% International Journal of Molecular Sciences 9 publications, 0.81%
Scientific Reports	Scientific Reports, 9, 0.81% Scientific Reports 9 publications, 0.81%
Computational and Structural Biotechnology Journal	Computational and Structural Biotechnology Journal, 9, 0.81% Computational and Structural Biotechnology Journal 9 publications, 0.81%
Antiviral Research	Antiviral Research, 8, 0.72% Antiviral Research 8 publications, 0.72%
Cell Reports Medicine	Cell Reports Medicine, 8, 0.72% Cell Reports Medicine 8 publications, 0.72%
Proceedings of the National Academy of Sciences of the United States of America	Proceedings of the National Academy of Sciences of the United States of America, 8, 0.72% Proceedings of the National Academy of Sciences of the United States of America 8 publications, 0.72%
Science advances	Science advances, 7, 0.63% Science advances 7 publications, 0.63%
mAbs	mAbs, 6, 0.54% mAbs 6 publications, 0.54%
Antibody Therapeutics	Antibody Therapeutics, 6, 0.54% Antibody Therapeutics 6 publications, 0.54%
Journal of Virology	Journal of Virology, 6, 0.54% Journal of Virology 6 publications, 0.54%
mBio	mBio, 6, 0.54% mBio 6 publications, 0.54%
Frontiers in Molecular Biosciences	Frontiers in Molecular Biosciences, 5, 0.45% Frontiers in Molecular Biosciences 5 publications, 0.45%
Frontiers in Microbiology	Frontiers in Microbiology, 5, 0.45% Frontiers in Microbiology 5 publications, 0.45%
Structure	Structure, 5, 0.45% Structure 5 publications, 0.45%
Journal of Molecular Biology	Journal of Molecular Biology, 5, 0.45% Journal of Molecular Biology 5 publications, 0.45%
	5 10 15 20 25 30 35

Citations by publishers

	50 100 150 200 250 300
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 279, 25.07% Cold Spring Harbor Laboratory 279 publications, 25.07%
Elsevier	Elsevier, 226, 20.31% Elsevier 226 publications, 20.31%
Springer Nature	Springer Nature, 175, 15.72% Springer Nature 175 publications, 15.72%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 76, 6.83% Multidisciplinary Digital Publishing Institute (MDPI) 76 publications, 6.83%
Frontiers Media S.A.	Frontiers Media S.A., 59, 5.3% Frontiers Media S.A. 59 publications, 5.3%
Wiley	Wiley, 38, 3.41% Wiley 38 publications, 3.41%
American Association for the Advancement of Science (AAAS)	American Association for the Advancement of Science (AAAS), 36, 3.23% American Association for the Advancement of Science (AAAS) 36 publications, 3.23%
Oxford University Press	Oxford University Press, 30, 2.7% Oxford University Press 30 publications, 2.7%
American Chemical Society (ACS)	American Chemical Society (ACS), 30, 2.7% American Chemical Society (ACS) 30 publications, 2.7%
American Society for Microbiology	American Society for Microbiology, 22, 1.98% American Society for Microbiology 22 publications, 1.98%
Taylor & Francis	Taylor & Francis, 20, 1.8% Taylor & Francis 20 publications, 1.8%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 19, 1.71% Public Library of Science (PLoS) 19 publications, 1.71%
Proceedings of the National Academy of Sciences (PNAS)	Proceedings of the National Academy of Sciences (PNAS), 8, 0.72% Proceedings of the National Academy of Sciences (PNAS) 8 publications, 0.72%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 6, 0.54% Royal Society of Chemistry (RSC) 6 publications, 0.54%
American Society for Clinical Investigation	American Society for Clinical Investigation, 5, 0.45% American Society for Clinical Investigation 5 publications, 0.45%
Future Medicine	Future Medicine, 5, 0.45% Future Medicine 5 publications, 0.45%
Rockefeller University Press	Rockefeller University Press, 5, 0.45% Rockefeller University Press 5 publications, 0.45%
NEJM Group	NEJM Group, 3, 0.27% NEJM Group 3 publications, 0.27%
KeAi Communications Co.	KeAi Communications Co., 3, 0.27% KeAi Communications Co. 3 publications, 0.27%
American Society for Biochemistry and Molecular Biology	American Society for Biochemistry and Molecular Biology, 3, 0.27% American Society for Biochemistry and Molecular Biology 3 publications, 0.27%
EMBO press	EMBO press, 3, 0.27% EMBO press 3 publications, 0.27%
American Medical Association (AMA)	American Medical Association (AMA), 3, 0.27% American Medical Association (AMA) 3 publications, 0.27%
Bentham Science	Bentham Science, 2, 0.18% Bentham Science 2 publications, 0.18%
International Union of Crystallography (IUCr)	International Union of Crystallography (IUCr), 2, 0.18% International Union of Crystallography (IUCr) 2 publications, 0.18%
Mary Ann Liebert	Mary Ann Liebert, 2, 0.18% Mary Ann Liebert 2 publications, 0.18%
Portland Press	Portland Press, 2, 0.18% Portland Press 2 publications, 0.18%
Wolters Kluwer Health	Wolters Kluwer Health, 2, 0.18% Wolters Kluwer Health 2 publications, 0.18%
Newlands Press Ltd	Newlands Press Ltd, 2, 0.18% Newlands Press Ltd 2 publications, 0.18%
Higher Education Press	Higher Education Press, 2, 0.18% Higher Education Press 2 publications, 0.18%
	50 100 150 200 250 300

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Hansen J. et al. Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail // Science. 2020. Vol. 369. No. 6506. pp. 1010-1014.

GOST all authors (up to 50) Copy

Hansen J., Baum A., Pascal K. E., Russo V., Giordano S., Wloga E., Fulton B. O., Yan Y., Koon K., Patel K., Chung K. M., Hermann A., Ullman E., Cruz J., Rafique A., Huang T., FAIRHURST J. L., Libertiny C., Malbec M., Lee W. Y., Welsh R., Farr G., Pennington S., Deshpande D., Cheng J., Watty A., Bouffard P., BABB R., Levenkova N., Chen C., Zhang B., Romero Hernandez A., Saotome K., Zhou Y., Franklin M., Sivapalasingam S., Lye D. C., Weston S., Logue J., Haupt R., Frieman M., Chen G., Olson W. H., Murphy A. J., Stahl N., Yancopoulos G. D., Kyratsous C. A. Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail // Science. 2020. Vol. 369. No. 6506. pp. 1010-1014.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1126/science.abd0827

UR - https://doi.org/10.1126/science.abd0827

TI - Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail

T2 - Science

AU - Hansen, Johanna

AU - Baum, Alina

AU - Pascal, Kristen E

AU - Russo, Vincenzo

AU - Giordano, Stephanie

AU - Wloga, Elzbieta

AU - Fulton, Benjamin O

AU - Yan, Ying

AU - Koon, Katrina

AU - Patel, Krunal

AU - Chung, Kyung Min

AU - Hermann, Aynur

AU - Ullman, Erica

AU - Cruz, Jonathan

AU - Rafique, Ashique

AU - Huang, Tammy

AU - FAIRHURST, JEANETTE L.

AU - Libertiny, Christen

AU - Malbec, Marine

AU - Lee, Wen Yi

AU - Welsh, Richard

AU - Farr, Glen

AU - Pennington, Seth

AU - Deshpande, Dipali

AU - Cheng, Jemmie

AU - Watty, Anke

AU - Bouffard, Pascal

AU - BABB, Robert

AU - Levenkova, Natasha

AU - Chen, Calvin

AU - Romero Hernandez, Annabel

AU - Saotome, Kei

AU - Zhou, Yi

AU - Sivapalasingam, Sumathi

AU - Lye, David Chien

AU - Weston, Stuart

AU - Logue, James

AU - Haupt, Robert

AU - Chen, Gang

AU - Olson, William H.

AU - Stahl, Neil

AU - Yancopoulos, George D.

AU - Kyratsous, Christos A.

AU - Zhang, Bojie

AU - Franklin, Matthew

AU - Frieman, Matthew

AU - Murphy, Andrew J.

PY - 2020

DA - 2020/08/21 00:00:00

PB - American Association for the Advancement of Science (AAAS)

SP - 1010-1014

IS - 6506

VL - 369

PMID - 32540901

SN - 0036-8075

SN - 1095-9203

ER -

BibTex |

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BibTex Copy

@article{2020_Hansen,

author = {Johanna Hansen and Alina Baum and Kristen E Pascal and Vincenzo Russo and Stephanie Giordano and Elzbieta Wloga and Benjamin O Fulton and Ying Yan and Katrina Koon and Krunal Patel and Kyung Min Chung and Aynur Hermann and Erica Ullman and Jonathan Cruz and Ashique Rafique and Tammy Huang and JEANETTE L. FAIRHURST and Christen Libertiny and Marine Malbec and Wen Yi Lee and Richard Welsh and Glen Farr and Seth Pennington and Dipali Deshpande and Jemmie Cheng and Anke Watty and Pascal Bouffard and Robert BABB and Natasha Levenkova and Calvin Chen and Annabel Romero Hernandez and Kei Saotome and Yi Zhou and Sumathi Sivapalasingam and David Chien Lye and Stuart Weston and James Logue and Robert Haupt and Gang Chen and William H. Olson and Neil Stahl and George D. Yancopoulos and Christos A. Kyratsous and Bojie Zhang and Matthew Franklin and Matthew Frieman and Andrew J. Murphy},

title = {Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail},

journal = {Science},

year = {2020},

volume = {369},

publisher = {American Association for the Advancement of Science (AAAS)},

month = {aug},

url = {https://doi.org/10.1126/science.abd0827},

number = {6506},

pages = {1010--1014},

doi = {10.1126/science.abd0827}

}

MLA

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MLA Copy

Hansen, Johanna, et al. “Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail.” Science, vol. 369, no. 6506, Aug. 2020, pp. 1010-1014. https://doi.org/10.1126/science.abd0827.

Found error?

Publisher

American Association for the Advancement of Science (AAAS)

Journal

Science

Quartile SCImago

Quartile WOS

Impact factor

56.9

ISSN

00368075 (Print)
10959203 (Electronic)

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