Open Access
Versatile and multivalent nanobodies efficiently neutralize SARS-CoV-2
Тип публикации: Journal Article
Дата публикации: 2020-12-18
SCImago Q1
Tоп 10% SCImago
WOS Q1
БС1
SJR: 10.948
CiteScore: 48.4
Impact factor: 45.8
ISSN: 00368075, 10959203
PubMed ID:
33154108
Multidisciplinary
Краткое описание
Nanobodies that neutralize
Monoclonal antibodies that bind to the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) show therapeutic promise but must be produced in mammalian cells and need to be delivered intravenously. By contrast, single-domain antibodies called nanobodies can be produced in bacteria or yeast, and their stability may enable aerosol delivery. Two papers now report nanobodies that bind tightly to spike and efficiently neutralize SARS-CoV-2 in cells. Schoof et al. screened a yeast surface display of synthetic nanobodies and Xiang et al. screened anti-spike nanobodies produced by a llama. Both groups identified highly potent nanobodies that lock the spike protein in an inactive conformation. Multivalent constructs of selected nanobodies achieved even more potent neutralization.
Science
, this issue p.
Найдено
Ничего не найдено, попробуйте изменить настройки фильтра.
Для доступа к списку цитирований публикации необходимо авторизоваться.
Для доступа к списку профилей, цитирующих публикацию, необходимо авторизоваться.
Топ-30
Журналы
|
10
20
30
40
50
60
70
|
|
|
bioRxiv
62 публикации, 17.51%
|
|
|
Frontiers in Immunology
13 публикаций, 3.67%
|
|
|
International Journal of Biological Macromolecules
9 публикаций, 2.54%
|
|
|
International Journal of Molecular Sciences
7 публикаций, 1.98%
|
|
|
Nature Communications
7 публикаций, 1.98%
|
|
|
Viruses
7 публикаций, 1.98%
|
|
|
Journal of Biological Chemistry
6 публикаций, 1.69%
|
|
|
Vaccines
5 публикаций, 1.41%
|
|
|
iScience
5 публикаций, 1.41%
|
|
|
Analytical Chemistry
5 публикаций, 1.41%
|
|
|
Proceedings of the National Academy of Sciences of the United States of America
5 публикаций, 1.41%
|
|
|
Communications Biology
4 публикации, 1.13%
|
|
|
Scientific Reports
4 публикации, 1.13%
|
|
|
Journal of Virology
4 публикации, 1.13%
|
|
|
Cell
3 публикации, 0.85%
|
|
|
Structure
3 публикации, 0.85%
|
|
|
Advanced Materials
3 публикации, 0.85%
|
|
|
Journal of Chemical Information and Modeling
3 публикации, 0.85%
|
|
|
mAbs
3 публикации, 0.85%
|
|
|
Science advances
3 публикации, 0.85%
|
|
|
EMBO Reports
3 публикации, 0.85%
|
|
|
medRxiv
3 публикации, 0.85%
|
|
|
eLife
3 публикации, 0.85%
|
|
|
Virology
3 публикации, 0.85%
|
|
|
Journal of Controlled Release
3 публикации, 0.85%
|
|
|
International Journal of Nanomedicine
2 публикации, 0.56%
|
|
|
Frontiers in Molecular Biosciences
2 публикации, 0.56%
|
|
|
Frontiers in Drug Discovery
2 публикации, 0.56%
|
|
|
Applied Microbiology and Biotechnology
2 публикации, 0.56%
|
|
|
10
20
30
40
50
60
70
|
Издатели
|
10
20
30
40
50
60
70
80
|
|
|
Elsevier
78 публикаций, 22.03%
|
|
|
openRxiv
65 публикаций, 18.36%
|
|
|
Springer Nature
47 публикаций, 13.28%
|
|
|
MDPI
29 публикаций, 8.19%
|
|
|
American Chemical Society (ACS)
22 публикации, 6.21%
|
|
|
Frontiers Media S.A.
20 публикаций, 5.65%
|
|
|
Wiley
20 публикаций, 5.65%
|
|
|
American Society for Microbiology
8 публикаций, 2.26%
|
|
|
Taylor & Francis
7 публикаций, 1.98%
|
|
|
Royal Society of Chemistry (RSC)
7 публикаций, 1.98%
|
|
|
American Society for Biochemistry and Molecular Biology
6 публикаций, 1.69%
|
|
|
Oxford University Press
5 публикаций, 1.41%
|
|
|
Public Library of Science (PLoS)
5 публикаций, 1.41%
|
|
|
American Association for the Advancement of Science (AAAS)
5 публикаций, 1.41%
|
|
|
Proceedings of the National Academy of Sciences (PNAS)
5 публикаций, 1.41%
|
|
|
European Molecular Biology Organization
4 публикации, 1.13%
|
|
|
eLife Sciences Publications
3 публикации, 0.85%
|
|
|
Akademiai Kiado
1 публикация, 0.28%
|
|
|
Microbiology Society
1 публикация, 0.28%
|
|
|
Massachusetts Medical Society
1 публикация, 0.28%
|
|
|
Portland Press
1 публикация, 0.28%
|
|
|
Cambridge University Press
1 публикация, 0.28%
|
|
|
Federation of American Societies for Experimental Biology (FASEB)
1 публикация, 0.28%
|
|
|
Rockefeller University Press
1 публикация, 0.28%
|
|
|
American Institute of Mathematical Sciences (AIMS)
1 публикация, 0.28%
|
|
|
Hindawi Limited
1 публикация, 0.28%
|
|
|
Annual Reviews
1 публикация, 0.28%
|
|
|
The Royal Society
1 публикация, 0.28%
|
|
|
Spandidos Publications
1 публикация, 0.28%
|
|
|
10
20
30
40
50
60
70
80
|
- Мы не учитываем публикации, у которых нет DOI.
- Статистика публикаций обновляется еженедельно.
Вы ученый?
Создайте профиль, чтобы получать персональные рекомендации коллег, конференций и новых статей.
Войти с ORCID
Метрики
354
Всего цитирований:
354
Цитирований c 2025:
38
(10.73%)
Цитировать
ГОСТ |
RIS |
BibTex |
MLA
Цитировать
ГОСТ
Скопировать
Xiang Y. et al. Versatile and multivalent nanobodies efficiently neutralize SARS-CoV-2 // Science. 2020. Vol. 370. No. 6523. pp. 1479-1484.
ГОСТ со всеми авторами (до 50)
Скопировать
Xiang Y., Nambulli S., Xiao Z., Liu H., Sang Z., Duprex W. P., Schneidman-Duhovny D., Zhang C., Shi Y. Versatile and multivalent nanobodies efficiently neutralize SARS-CoV-2 // Science. 2020. Vol. 370. No. 6523. pp. 1479-1484.
Цитировать
RIS
Скопировать
TY - JOUR
DO - 10.1126/science.abe4747
UR - https://doi.org/10.1126/science.abe4747
TI - Versatile and multivalent nanobodies efficiently neutralize SARS-CoV-2
T2 - Science
AU - Xiang, Yufei
AU - Nambulli, Sham
AU - Xiao, Zhengyun
AU - Liu, Heng
AU - Sang, Zhe
AU - Duprex, W. Paul
AU - Schneidman-Duhovny, Dina
AU - Zhang, Cheng
AU - Shi, Yi
PY - 2020
DA - 2020/12/18
PB - American Association for the Advancement of Science (AAAS)
SP - 1479-1484
IS - 6523
VL - 370
PMID - 33154108
SN - 0036-8075
SN - 1095-9203
ER -
Цитировать
BibTex (до 50 авторов)
Скопировать
@article{2020_Xiang,
author = {Yufei Xiang and Sham Nambulli and Zhengyun Xiao and Heng Liu and Zhe Sang and W. Paul Duprex and Dina Schneidman-Duhovny and Cheng Zhang and Yi Shi},
title = {Versatile and multivalent nanobodies efficiently neutralize SARS-CoV-2},
journal = {Science},
year = {2020},
volume = {370},
publisher = {American Association for the Advancement of Science (AAAS)},
month = {dec},
url = {https://doi.org/10.1126/science.abe4747},
number = {6523},
pages = {1479--1484},
doi = {10.1126/science.abe4747}
}
Цитировать
MLA
Скопировать
Xiang, Yufei, et al. “Versatile and multivalent nanobodies efficiently neutralize SARS-CoV-2.” Science, vol. 370, no. 6523, Dec. 2020, pp. 1479-1484. https://doi.org/10.1126/science.abe4747.
Ошибка в публикации?