Open Access

Science, volume 370, issue 6523, pages 1479-1484

Versatile and multivalent nanobodies efficiently neutralize SARS-CoV-2

Yufei Xiang ¹

Sham Nambulli ^{2, 3}

Zhengyun Xiao ¹

Heng Liu ⁴

Zhe Sang ^{1, 5}

W. Paul Duprex ^{2, 3}

Dina Schneidman-Duhovny ⁶

Cheng Zhang ⁴

Yi Shi ^{1, 5}

Hide authors affiliations Show authors affiliations: 6 affiliations

Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA, USA. |

Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA. |

Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, USA. |

⁴

Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA. |

⁵

University of Pittsburgh–Carnegie Mellon University Program in Computational Biology, Pittsburgh, PA, USA. |

⁶

School of Computer Science and Engineering, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel. |

Publication type: Journal Article

Publication date: 2020-12-18

American Association for the Advancement of Science (AAAS)

Journal: Science

Quartile SCImago

Quartile WOS

Impact factor: 56.9

ISSN: 00368075, 10959203

DOI: 10.1126/science.abe4747

Copy DOI

Multidisciplinary

Abstract

Nanobodies that neutralize

Monoclonal antibodies that bind to the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) show therapeutic promise but must be produced in mammalian cells and need to be delivered intravenously. By contrast, single-domain antibodies called nanobodies can be produced in bacteria or yeast, and their stability may enable aerosol delivery. Two papers now report nanobodies that bind tightly to spike and efficiently neutralize SARS-CoV-2 in cells. Schoof et al. screened a yeast surface display of synthetic nanobodies and Xiang et al. screened anti-spike nanobodies produced by a llama. Both groups identified highly potent nanobodies that lock the spike protein in an inactive conformation. Multivalent constructs of selected nanobodies achieved even more potent neutralization.

Science , this issue p. 1473 , p. 1479

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Citations by journals

	2 4 6 8 10 12
Frontiers in Immunology	Frontiers in Immunology, 12, 4.03% Frontiers in Immunology 12 publications, 4.03%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 7, 2.35% International Journal of Molecular Sciences 7 publications, 2.35%
Nature Communications	Nature Communications, 7, 2.35% Nature Communications 7 publications, 2.35%
International Journal of Biological Macromolecules	International Journal of Biological Macromolecules, 7, 2.35% International Journal of Biological Macromolecules 7 publications, 2.35%
Viruses	Viruses, 6, 2.01% Viruses 6 publications, 2.01%
Journal of Biological Chemistry	Journal of Biological Chemistry, 6, 2.01% Journal of Biological Chemistry 6 publications, 2.01%
iScience	iScience, 5, 1.68% iScience 5 publications, 1.68%
Proceedings of the National Academy of Sciences of the United States of America	Proceedings of the National Academy of Sciences of the United States of America, 5, 1.68% Proceedings of the National Academy of Sciences of the United States of America 5 publications, 1.68%
Vaccines	Vaccines, 4, 1.34% Vaccines 4 publications, 1.34%
Scientific Reports	Scientific Reports, 4, 1.34% Scientific Reports 4 publications, 1.34%
Journal of Virology	Journal of Virology, 4, 1.34% Journal of Virology 4 publications, 1.34%
Communications Biology	Communications Biology, 3, 1.01% Communications Biology 3 publications, 1.01%
Structure	Structure, 3, 1.01% Structure 3 publications, 1.01%
Analytical Chemistry	Analytical Chemistry, 3, 1.01% Analytical Chemistry 3 publications, 1.01%
Science advances	Science advances, 3, 1.01% Science advances 3 publications, 1.01%
EMBO Reports	EMBO Reports, 3, 1.01% EMBO Reports 3 publications, 1.01%
eLife	eLife, 3, 1.01% eLife 3 publications, 1.01%
Virology	Virology, 3, 1.01% Virology 3 publications, 1.01%
International Journal of Nanomedicine	International Journal of Nanomedicine, 2, 0.67% International Journal of Nanomedicine 2 publications, 0.67%
Frontiers in Molecular Biosciences	Frontiers in Molecular Biosciences, 2, 0.67% Frontiers in Molecular Biosciences 2 publications, 0.67%
Frontiers in Drug Discovery	Frontiers in Drug Discovery, 2, 0.67% Frontiers in Drug Discovery 2 publications, 0.67%
Applied Microbiology and Biotechnology	Applied Microbiology and Biotechnology, 2, 0.67% Applied Microbiology and Biotechnology 2 publications, 0.67%
Nature Nanotechnology	Nature Nanotechnology, 2, 0.67% Nature Nanotechnology 2 publications, 0.67%
Cell	Cell, 2, 0.67% Cell 2 publications, 0.67%
Current Opinion in Virology	Current Opinion in Virology, 2, 0.67% Current Opinion in Virology 2 publications, 0.67%
Cell Reports	Cell Reports, 2, 0.67% Cell Reports 2 publications, 0.67%
Acta Pharmaceutica Sinica B	Acta Pharmaceutica Sinica B, 2, 0.67% Acta Pharmaceutica Sinica B 2 publications, 0.67%
Advanced Drug Delivery Reviews	Advanced Drug Delivery Reviews, 2, 0.67% Advanced Drug Delivery Reviews 2 publications, 0.67%
Biomedicine and Pharmacotherapy	Biomedicine and Pharmacotherapy, 2, 0.67% Biomedicine and Pharmacotherapy 2 publications, 0.67%
	2 4 6 8 10 12

Citations by publishers

	10 20 30 40 50 60 70
Elsevier	Elsevier, 61, 20.47% Elsevier 61 publications, 20.47%
Cold Spring Harbor Laboratory	Cold Spring Harbor Laboratory, 55, 18.46% Cold Spring Harbor Laboratory 55 publications, 18.46%
Springer Nature	Springer Nature, 40, 13.42% Springer Nature 40 publications, 13.42%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 25, 8.39% Multidisciplinary Digital Publishing Institute (MDPI) 25 publications, 8.39%
Frontiers Media S.A.	Frontiers Media S.A., 19, 6.38% Frontiers Media S.A. 19 publications, 6.38%
Wiley	Wiley, 17, 5.7% Wiley 17 publications, 5.7%
American Chemical Society (ACS)	American Chemical Society (ACS), 16, 5.37% American Chemical Society (ACS) 16 publications, 5.37%
American Society for Microbiology	American Society for Microbiology, 7, 2.35% American Society for Microbiology 7 publications, 2.35%
American Society for Biochemistry and Molecular Biology	American Society for Biochemistry and Molecular Biology, 6, 2.01% American Society for Biochemistry and Molecular Biology 6 publications, 2.01%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 5, 1.68% Royal Society of Chemistry (RSC) 5 publications, 1.68%
American Association for the Advancement of Science (AAAS)	American Association for the Advancement of Science (AAAS), 5, 1.68% American Association for the Advancement of Science (AAAS) 5 publications, 1.68%
Proceedings of the National Academy of Sciences (PNAS)	Proceedings of the National Academy of Sciences (PNAS), 5, 1.68% Proceedings of the National Academy of Sciences (PNAS) 5 publications, 1.68%
Oxford University Press	Oxford University Press, 4, 1.34% Oxford University Press 4 publications, 1.34%
Taylor & Francis	Taylor & Francis, 4, 1.34% Taylor & Francis 4 publications, 1.34%
EMBO press	EMBO press, 4, 1.34% EMBO press 4 publications, 1.34%
eLife Sciences Publications	eLife Sciences Publications, 3, 1.01% eLife Sciences Publications 3 publications, 1.01%
Dove Medical Press	Dove Medical Press, 2, 0.67% Dove Medical Press 2 publications, 0.67%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 2, 0.67% Public Library of Science (PLoS) 2 publications, 0.67%
The Chemical Society of Japan	The Chemical Society of Japan, 1, 0.34% The Chemical Society of Japan 1 publication, 0.34%
Akademiai Kiado	Akademiai Kiado, 1, 0.34% Akademiai Kiado 1 publication, 0.34%
Microbiology Society	Microbiology Society, 1, 0.34% Microbiology Society 1 publication, 0.34%
NEJM Group	NEJM Group, 1, 0.34% NEJM Group 1 publication, 0.34%
Portland Press	Portland Press, 1, 0.34% Portland Press 1 publication, 0.34%
Cambridge University Press	Cambridge University Press, 1, 0.34% Cambridge University Press 1 publication, 0.34%
Federation of American Societies for Experimental Biology (FASEB)	Federation of American Societies for Experimental Biology (FASEB), 1, 0.34% Federation of American Societies for Experimental Biology (FASEB) 1 publication, 0.34%
Rockefeller University Press	Rockefeller University Press, 1, 0.34% Rockefeller University Press 1 publication, 0.34%
American Institute of Mathematical Sciences (AIMS)	American Institute of Mathematical Sciences (AIMS), 1, 0.34% American Institute of Mathematical Sciences (AIMS) 1 publication, 0.34%
Hindawi Limited	Hindawi Limited, 1, 0.34% Hindawi Limited 1 publication, 0.34%
Annual Reviews	Annual Reviews, 1, 0.34% Annual Reviews 1 publication, 0.34%
	10 20 30 40 50 60 70

We do not take into account publications without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
Statistics recalculated weekly.

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Xiang Y. et al. Versatile and multivalent nanobodies efficiently neutralize SARS-CoV-2 // Science. 2020. Vol. 370. No. 6523. pp. 1479-1484.

GOST all authors (up to 50) Copy

Xiang Y., Nambulli S., Xiao Z., Liu H., Sang Z., Duprex W. P., Schneidman-Duhovny D., Zhang C., Shi Y. Versatile and multivalent nanobodies efficiently neutralize SARS-CoV-2 // Science. 2020. Vol. 370. No. 6523. pp. 1479-1484.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1126/science.abe4747

UR - https://doi.org/10.1126/science.abe4747

TI - Versatile and multivalent nanobodies efficiently neutralize SARS-CoV-2

T2 - Science

AU - Xiang, Yufei

AU - Nambulli, Sham

AU - Xiao, Zhengyun

AU - Liu, Heng

AU - Sang, Zhe

AU - Duprex, W. Paul

AU - Schneidman-Duhovny, Dina

AU - Zhang, Cheng

AU - Shi, Yi

PY - 2020

DA - 2020/12/18 00:00:00

PB - American Association for the Advancement of Science (AAAS)

SP - 1479-1484

IS - 6523

VL - 370

SN - 0036-8075

SN - 1095-9203

ER -

BibTex |

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BibTex Copy

@article{2020_Xiang,

author = {Yufei Xiang and Sham Nambulli and Zhengyun Xiao and Heng Liu and Zhe Sang and W. Paul Duprex and Dina Schneidman-Duhovny and Cheng Zhang and Yi Shi},

title = {Versatile and multivalent nanobodies efficiently neutralize SARS-CoV-2},

journal = {Science},

year = {2020},

volume = {370},

publisher = {American Association for the Advancement of Science (AAAS)},

month = {dec},

url = {https://doi.org/10.1126/science.abe4747},

number = {6523},

pages = {1479--1484},

doi = {10.1126/science.abe4747}

}

MLA

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MLA Copy

Xiang, Yufei, et al. “Versatile and multivalent nanobodies efficiently neutralize SARS-CoV-2.” Science, vol. 370, no. 6523, Dec. 2020, pp. 1479-1484. https://doi.org/10.1126/science.abe4747.

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Publisher

American Association for the Advancement of Science (AAAS)

Journal

Science

Quartile SCImago

Quartile WOS

Impact factor

56.9

ISSN

00368075 (Print)
10959203 (Electronic)